| X染色体遗传标记的研究应用进展 |
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| 引用本文： | 许淼,李淑瑾,丛斌,马春玲.X染色体遗传标记的研究应用进展[J].中国司法鉴定,2013(2):49-54. |
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| 作者姓名： | 许淼 李淑瑾 丛斌 马春玲 |
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| 作者单位： | 河北医科大学法医学系河北省法医学重点实验室,河北石家庄,050017 |
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| 摘 要： | X染色体遗传标记在法医学中占有不可或缺的位置,因其独特的结构和遗传特征而被应用于复杂亲缘鉴定。目前应用于法医遗传学领域的有超过50个高度多态性X-STRs,筛选到高度多态性的X-SNPs和X-Indels的数量也在逐渐增加,且X染色体特异性遗传标记对复杂疾病的易感性也受到了临床工作者的重视。本文就X染色体遗传标记在法医学及临床医学上的研究和应用进行综述。
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| 关 键 词： | 法医遗传学 X染色体 亲缘关系鉴定 复杂疾病易感性 |
Progress and Application of X Chromosome Genetic markers |
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| XU Miao,LI Shu-jin,CONG Bin,MA Chun-ling.Progress and Application of X Chromosome Genetic markers[J].Chinese Journal of Forensic Sciences,2013(2):49-54. |
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| Authors: | XU Miao LI Shu-jin CONG Bin MA Chun-ling |
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| Institution: | (Hebei Key Laboratory of Forensic Medicine, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang 050017, China) |
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| Abstract: | The X chromosome genetic markers occupy an indispensable position in forensic genetics. With their umque struc-ture and genetic characteristics, they have been applied in the complex paternity testing cases. At present, more than 50 high polymorphism X-STRs have been found, and the number of high polymorphic X-SNPs and X-Indels has been increasing gradually. Moreover, the complex diseases susceptibility of specific X chromosome genetic markers has also attracted clinical workers＇ attention. This paper reviewed the research and application of X chromosome genetic markers for forensic and clinical medicine purpose. |
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| Keywords: | forensic genetics X chromosome paternity testing susceptibility of complex disease |
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