The polymorphisms of 12 X-STR loci in six ethnic populations in China |
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| Institution: | 1. Laboratorio de Genética Humana, Universidad Nacional Mayor de San Marcos, Lima, Peru;2. GENES Ltda, Medellín, Colombia;3. Instituto de Biología, Universidad de Antioquia, Medellín, Colombia;4. IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;1. Department of Medical and Surgical Sciences, DIMEC, Institute of Legal Medicine, University of Bologna, Italy;2. Department of Biological, Geological and Environmental Sciences, BIGEA, Laboratory of Molecular Anthropology, University of Bologna, Italy;1. University Department for Forensic Sciences, University of Split, Split, Croatia;2. Ruđer Bošković Institute, Zagreb, Croatia;3. Forensic Science Centre “Ivan Vučetić”, Zagreb, Croatia;4. Forensic Science Office, University of Zagreb, Zagreb, Croatia;5. Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia;1. Institute of Legal Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;2. Human Genetics Laboratory, University of Madeira, Funchal, Portugal;3. DNA Diagnostic Laboratory (LDD), Institute of Biology, State University of Rio de Janeiro (UERJ), Brazil;4. IPATIMUP, Institute of Pathology and Molecular Immunology of the University of Porto, Porto, Portugal;5. Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal;1. Institut Universitari d’Investigació en Ciències de la Salut (IUNICS) i Laboratori de Genètica, Departament de Biologia, Universitat de les Illes Balears, Carretera de Valldemossa, km 7.5, 07122, Palma de Mallorca, Illes Balears, Spain;2. Biochemistry and Immunology Laboratory-Forensic Unit, Mohammed V Agdal University, Faculty of Sciences, Avenue Ibn Batouta Agdal, BP 1014 Rabat, Morocco;3. i3S − Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal;4. IPATIMUP − Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Júlio Amaral de Carvalho, 45, 4200-135 Porto, Portugal;5. Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal |
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| Abstract: | To explore the genetic polymorphisms of 12 X-STR loci for Guangdong Han population and other five minor ethnic populations (Tibetan, Mongolian, Korean, Uighur and Hui) in China, 1298 samples from unrelated individuals of these 6 ethnic populations were amplified with Investigator™ Argus X-12 multiplex PCR system. 238 alleles were observed totally, which included 66 off-ladder alleles. All the loci showed no difference in sex-related allele frequency. The combined discrimination power (CDP) was ranged from 0.999999996 to 0.999999999 in males for these 6 populations and the CDP value in females was all reached 0.999999999. The combined mean exclusion chance (CMEC) was ranged from 0.999998336 to 0.999999926 in duo paternity cases and 0.999999987 to 0.999999999 in trio paternity cases in 6 populations. All of the 12 loci were in accordance with Hardy–Weinberg equilibrium after Bonferroni's correction. Linkage disequilibrium was observed for DXS10103–DXS10101 pair in 6 populations. Significant differences between all pairs of populations were observed at 2–11 loci respectively. The phylogenetic tree consisted of two main branches for these 6 populations, which was consistent with the geographic and historic distributions. |
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| Keywords: | X-STR Polymorphism Chinese ethnic populations |
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