| GC/MS研究海洛因代谢物在吸毒者体内的分布 |
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| 作者姓名： | Xiang P Shen M Wu HJ Huang ZJ |
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| 作者单位： | 司法部司法鉴定科学技术研究所!上海,200063,司法部司法鉴定科学技术研究所!上海,200063,司法部司法鉴定科学技术研究所!上海,200063,司法部司法鉴定科学技术研究所!上海,200063 |
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| 摘 要： | 应用GC／MS－SIM测定了海洛因代谢物吗啡在两例海洛因延缓死亡者的体内分布,并分析了收集到的7例案子的毛发（头发、腋毛和阴毛）中6-单乙酰吗啡和吗啡含量。生物检材和毛发经酸水解、提取、醋酸酐或双（三甲基硅基）三氟乙酰胺（BSTFA）衍生化,然后进行GC／MS-SIM分析。结果表明尿、胆汁和肝脏是判定死者是否曾使用海洛因的最佳检材;毛发分析与生物检材相比有其独特的优点,可提供数月甚至数年的用药情况。为公安司法机关打击吸毒、惩治犯罪提供更可靠、有效的证据。
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| 关 键 词： | GC／MS－SIM 体液 组织 毛发 代谢物 吗啡 6-单乙酰吗啡 衍生化 |
Determination of heroin metabolites in biological fluids,tissues and hair of heroin addicts using GC/MS-SIM |
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| Xiang P,Shen M,Wu HJ,Huang ZJ.Determination of heroin metabolites in biological fluids,tissues and hair of heroin addicts using GC/MS-SIM[J].Journal of Forensic Medicine,1999,15(4):208-210. |
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| Authors: | Xiang P Shen M Wu H J Huang Z J |
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| Institution: | Institute of Forensic Sciences, Ministry of Justice, Shanghai 200063, P. R. China. |
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| Abstract: | Using GC/MS - SIM, we examined morPhine distribution in human bodies of 2 delayed death cases and analyzed content of morphine and 6 - acetylmorphine (MAM) in hair specimens of 7 cases. Afer hydrolysis and extraction, MoR and 6 - MAM were derived with acetic anhydride or BSTFA and then the derivatives were qualitatively and quantitatively analyzed by GC/MS SIM. The results indicated that urine, bile and liver were the best samples to reveal the heroin - related deaths. Hair analysis has its unique advantage for its long time of abusing monitor, compared to biological fluids. |
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| Keywords: | GC/MS-SIM biological fluid tissue hair metabolite derivative 6-acetylmorphine morphine |
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