| 度冷丁滥用者尿中原体及其代谢产物的分析研究 |
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| 引用本文： | 沈敏,薛月华,沈保华,向平,刘伟.度冷丁滥用者尿中原体及其代谢产物的分析研究[J].法医学杂志,1996(2). |
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| 作者姓名： | 沈敏 薛月华 沈保华 向平 刘伟 |
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| 作者单位： | 司法部司法鉴定科学技术研究所，上海市第一人民医院护士学校 |
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| 摘 要： | 本研究利用ＧＣ／ＭＳ（ＥＩ．ＰＣＩ）技术，在度冷丁滥用者尿中确认了６种代谢产物。并建立了ＧＣ／ＦＩＤ分析度冷丁及其代谢产物的方法。方法线性范围为０．１～２０μｇ／ｍｌ，变异系数小于１０％，最小检出量为５０ｎｇ／ｍｌ，适用于度冷丁成瘾者尿中含量的测定。
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| 关 键 词： | 度冷丁，去甲度冷丁，尿，气相色谱法，气质联用法 |
Studies on the Analysis of Meperidine and its Main Metabolites in urine of Meperidine Addicts |
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| Shen Min, Xue Yuehua, Shen Bao hua,Xiang Ping, Liu Wei.Studies on the Analysis of Meperidine and its Main Metabolites in urine of Meperidine Addicts[J].Journal of Forensic Medicine,1996(2). |
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| Authors: | Shen Min Xue Yuehua Shen Bao hua Xiang Ping Liu Wei |
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| Abstract: | Six meperidine metabolites are identified by GC/MS(EI, PCI) in the urine of meperidine addicts.A GC/FID procedure for determination of meperidine and its main metabolites in human urine is also developed. Calibration curve is lineat over the rang 0. 1-20ug/ml, me results reproducible (cv<10%), the sensitivity limit is about 50ng/ml.The method is shown to be applicable to measuring urine concentra-tion of meperidine addicts. |
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| Keywords: | meperidine normeperidine urine GC/FID DC/MS |
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