| 尿中MDMA及其代谢物的GC和GC／MS分析 |
| |
| 作者姓名： | Shen M Yan W Shen B Xiang P Huang Z Liu W Bo J |
| |
| 作者单位： | 司法部司法鉴定科学技术研究所!海,200063,上海刑事科学技术研究所!上海,200083,司法部司法鉴定科学技术研究所!海,200063,司法部司法鉴定科学技术研究所!海,200063,司法部司法鉴定科学技术研究所!海,200063,司法部司法鉴定科学技术研究所!海,200063,司法部司法鉴定科学技术研 |
| |
| 摘 要： | 考察MDMA在人体内的代谢以及建立尿中MDMA和体内主要代谢物MDA的分析方法。尿样水解后经液-液提取处理,用GC／MS（EI、PCI）和GC／FID法分析。人摄入MDMA后尿中MDA和原体MDMA比约为0．10～0．14。GC／MS／SIM和GC／FID法的最低检出限为2ng／ml和50ng／ml,回收率大于85％,变异系数小于10％。该法简便快速、灵敏度高、结果可靠,可用于MDMA滥用者的尿样鉴定。MDA／MDMA浓度比可作为评判毒分结果的参考指标。
|
| 关 键 词： | MDMA 代谢物 代谢物与原体浓度比 |
Analysis of MDMA and its metabolites in urine by GC and GC/MS |
| |
| Shen M,Yan W,Shen B,Xiang P,Huang Z,Liu W,Bo J.Analysis of MDMA and its metabolites in urine by GC and GC/MS[J].Journal of Forensic Medicine,1998,14(1):10-11,24. |
| |
| Authors: | Shen M Yan W Shen B Xiang P Huang Z Liu W Bo J |
| |
| Institution: | Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063. |
| |
| Abstract: | The purpose of this study is to investigate the metabolism of MDMA in the person and establish the methods for the determination of MDMA and its metabolites in urine. MDMA and its metabolite were isolated from urine by liquid-liquid extraction after acidic or enzymatic hydrolysis and were determined by GC/MS(EI, PCI) and GC/FID. The results showed that MDMA was metabolized to MDA and HMMA in man. MDA in the urine after MDMA administration was approximately 0.10-0.14 that of the parent drug. The sensitivity limits of methods were 2-50 ng/ml, and the recoveries were greater than 85%(CV < 10%). It is concluded that the methods were simple, quick and accurate for determining urine concentration of MDMA addicts. MDA/MDMA Ratio can be used to indicate whether the parent drug is taken alone or in combination with its active metabolite. |
| |
| Keywords: | MDMA metabolites metabolite to parent ratio |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
|
