| 华东地区汉族人群D2S1399和D5S2500基因座的遗传多态性研究 |
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| 作者姓名： | Xia SX Gao YZ Bian SZ Wang Z Zhang Z Bu M Zhang J |
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| 作者单位： | 1. 苏州大学医学院基础医学系法医学教研室,江苏,苏州,215007
2. 司法部司法鉴定科学技术研究所,上海,200063 |
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| 摘 要： | 目的研究D2S1399和D5S2500基因座在中国华东地区汉族群体遗传多态性。方法应用PCR、聚丙烯酰胺垂直电泳及银染技术检测D2S1399和D5S2500基因座的遗传多态性。结果D2S1399和D5S2500基因座在中国华东汉族群体分别检出11个和9个等位基因,其观察杂合度(Ho)分别为0.745和0.807,多态信息含量(PIC)分别为0.850和0.750,个体识别能力(DP)分别为0.958和0.917,非父排除率(PE)分别为0.554和0.643。结论D2S1399和D5S2500两个基因座是高度多态性STR基因座,在法医学中有重要应用价值。
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| 关 键 词： | D2S1399 D5S2500 遗传多态性 法医学 |
| 文章编号： | 1004-5619(2004)04-0200-02 |
| 修稿时间： | 2003年12月26 |
Genetic polymorphism of two STR loci D2S1399 and D5S2500 in Eastern Chinese Han population |
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| Xia SX,Gao YZ,Bian SZ,Wang Z,Zhang Z,Bu M,Zhang J.Genetic polymorphism of two STR loci D2S1399 and D5S2500 in Eastern Chinese Han population[J].Journal of Forensic Medicine,2004,20(4):200-201,204. |
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| Authors: | Xia Shui-xiu Gao Yu-zhen Bian Shi-zhong Wang Zufeng Zhang Zhixiang Bu Ming Zhang Jianhua |
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| Institution: | Department of Forensic Medicine, Medical School of Soochow University, Suzhou 215007, China. |
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| Abstract: | Objective To obtain the genetic polymorphism data of two STR loci D2S1399 and D5S2500 in Eastern Chinese Han population. Methods Blood samples or buccal swabs of unrelated Han individuals living in eastern China were analyzed using PCR-nature polyacrylamide gel electrophoresis-sliver staining method. Results 11 alleles of D2S1399 and 9 alleles of D5S2500 were observed in the samples respectively, the observed heterozygosity (Ho) values, the discrimination power (DP) values and the power of exclusion(PE) values of D2S1399 and D5S2500 is 0.745 and 0.807, 0.958 and 0.917, 0.554 and 0.643, respectively. Conclusion The result showed that D2S1399 and D5S2500 were highly informative loci and suitable for forensic application. |
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| Keywords: | D2S1399 D5S2500 genetic polymorphism forensic science |
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