| 维生素D受体基因多态性研究进展 |
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| 作者姓名： | Xu B Wang BJ |
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| 作者单位： | 中国医科大学法医学院,辽宁,沈阳,110001 |
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| 摘 要： | 维生素D受体(vitaminDreceptor,VDR)基因多态性可能与骨密度、骨质疏松、身高相关。本文作者就近年国内外所开展的VDR基因4个单核苷酸多态性(singlenucleotidepolymorphism,SNP)位点FokI、BsmI、ApaI、TaqI与骨密度、骨质疏松、身高关联性研究进行综述,发现各国的研究结果虽不尽相同,但VDR基因多态性在遗传学、临床内分泌代谢,尤其在法医学领域对身高的研究中,有重要的应用价值。
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| 关 键 词： | VDR基因 多态性 骨密度 骨质疏松 身高 |
| 文章编号： | 1004-5619(2005)01-0055-03 |
| 修稿时间： | 2003年11月17 |
Advances in the research of vitamin D receptor gene |
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| Xu B,Wang BJ.Advances in the research of vitamin D receptor gene[J].Journal of Forensic Medicine,2005,21(1):55-57,60. |
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| Authors: | Xu Bo Wang Bao-jie |
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| Institution: | School of Forensic Medicine, China Medical University, Shenyang. |
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| Abstract: | The polymorphism of vitamin D receptor (VDR) gene may be associated with bone density, osteoporosis and body height. In this review, the authors summarize the association of the four VDR single nucleotide polymorphisms (SNPs) loci FokI, BsmI, ApaI, TaqI with bone density, osteoporosis and body height reported at home and abroad in recent years. And find that though each country's report may be different, its valuable in the field of genetics, clinical endocrinology and metabolism, especially in the research area of body height in forensic medicine. |
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| Keywords: | VDR gene polymorphism bone density osteoporosis body height |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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