DNA甲基化推断人类年龄的研究进展

在法庭科学实践中,年龄是重要的个体信息,是刻画嫌疑人特征首先要考虑的指标之一。近年来,DNA甲基化因其出色的准确性和稳定性成为年龄推断的研究热点。在DNA甲基化位点的特异性、跨组织年龄推断、未成年人的DNA甲基化年龄推断、年龄推断的灵敏度和法医学实际应用等方面均取得了新进展。同时,一些研究建立了更精确的统计建模方法、消除不同检测平台的差异、找寻模型中合适的位点数量、分析了环境和疾病的影响,本文对此进行综述以提供参考。

Research Progress on Human Age Estimation Based on DNA Methylation

In forensic science practice,age is an important individual information,and one of the indicators to be considered first to depict features of the suspect.Recently,DNA methylation has become a research hotspot in age estimation because of its hig accuracy and stability.New progress has been made in specificity of DNA methylation sites,age estimation in multiple tissues,DNA methylation age estimation of minors,sensitivity of age estimation,forensic practical applications,etc.At the same time,several studies also established more accurate statistical modeling methods,eliminated differences between different detection platforms,found appropriate number of sites in models and analyzed the influence of environment and diseases.This review summarizes these to provide references.