| 采用Identifiler系统判定消化系统肿瘤组织身源准则探讨 |
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| 作者姓名： | Zhao SM Zhang SH Li CT |
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| 作者单位： | 司法部司法鉴定科学技术研究所上海市法医学重点实验室; |
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| 基金项目： | 上海市自然科学基金项目(11ZR1438400); 中央级科研院所社会公益研究资助项目(GY1002) |
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| 摘 要： | 目的 探讨采用Identifiler系统进行消化系统肿瘤组织身源判定时共有等位基因数(IAn)和全相同基因座数(A2)的标准.方法 在对l05对消化系统肿瘤组织-身源正常组织对进行Identifiler系统分型的基础上,依据IAn和A2的有限分布原则,将IAn的16种取值代入已建立的相应判别函数,通过Fisher判别准...
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| 关 键 词： | 法医遗传学 肿瘤 STR 变异 个体识别 |
A primary study of criterion for source identification of gastrointestinal tumor sample with Identifiler multiplex system |
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| Zhao SM,Zhang SH,Li CT.A primary study of criterion for source identification of gastrointestinal tumor sample with Identifiler multiplex system[J].Journal of Forensic Medicine,2011,27(2):102-106. |
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| Authors: | Zhao Shu-min Zhang Su-hua Li Cheng-tao |
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| Institution: | ZHAO Shu-min,ZHANG Su-hua,LI Cheng-tao(Shanghai Key Laboratory of Forensic Medicine,Institute of Forensic Science,Ministry of Justice,P.R.China,Shanghai 200063,China) |
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| Abstract: | Objective To investigate the criterion for source identification of gastrointestinal tumor based on the number of identical allele(IAn) and the number of matched STR locus with 2 identical alleles(A2) in Identifiler system.Methods One hundred and five pairs of gastrointestinal tumor samples and homologous normal samples(TN group) were genotyped with Identifiler system.The numbers of STR locus with genotypic alteration(STRGA) in each tumor were determined by comparing the genotype of the matched STR loci in ... |
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| Keywords: | forensic genetics tumor STR mutation personal identification |
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