| 细菌素在动物疾病防治中的作用和机理研究进展 |
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| 引用本文： | 刘宝生,尚雅静,张日俊.细菌素在动物疾病防治中的作用和机理研究进展[J].中国兽医科学,2010,40(3). |
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| 作者姓名： | 刘宝生 尚雅静 张日俊 |
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| 作者单位： | 刘宝生(中国农业大学,饲料生物技术实验室,动物营养学国家重点实验室,北京,100193;江西农业大学,动物科学技术学院,江西,南昌,330045);尚雅静,张日俊(中国农业大学,饲料生物技术实验室,动物营养学国家重点实验室,北京,100193) |
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| 基金项目： | 国家高技术研究发展计划(863)项目 |
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| 摘 要： | 从细菌素的性质、生产与制备、在动物疾病防治中的作用、抑(杀)菌机理及安全性评价等方面概述了此类由细菌分泌的高效抗菌蛋白类物质的研究进展。认为,细菌素不仅在体外对各种致病菌具有较强的抑杀作用,而且经口服能显著抑制动物胃肠道内的有害菌,腹腔或静脉注射后可防治动物全身性细菌感染,无任何毒害作用,是一类可用于动物疾病防治的理想的抗生素替代品。
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| 关 键 词： | 细菌素 抗生素替代品 动物疾病防治 抗菌机理 安全评价 |
Advance in effects and mechanisms of bacteriocin on prophylaxis and control of animal disease |
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| LIU Bao-sheng,SHANG Ya-jing,ZHANG Ri-jun.Advance in effects and mechanisms of bacteriocin on prophylaxis and control of animal disease[J].Veterinary Science in China,2010,40(3). |
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| Authors: | LIU Bao-sheng SHANG Ya-jing ZHANG Ri-jun |
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| Institution: | LIU Bao-sheng1,2,SHANG Ya-jing1,ZHANG Ri-jun1(1.State Key Laboratory of Animal Nutrition/Laboratory of Feed Biotechnology,China Agricultural University,Beijing 100193,China,2.College of Animal Science , Technology,Jiangxi Agricultural University,Nanchang 330045,China) |
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| Abstract: | Bacteriocins,a kind of antibacterial proteins secreted by bacteria,were reviewed on the aspects of their properties,production and preparation,role in the prophylaxis and control of animal diseases,bacteriostatic or/and sterilization mechanism,and safety evaluation.It was pointed out that the bacteriocins could significantly inhibit pathogenic bacteria in vitro,significantly inhibit harmful bacteria in animal gastrointestine by oral administration,and prevent systemic bacterial infection by intraperitoneal ... |
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| Keywords: | bacteriocin antibiotic alternative animal disease control antibacterial mechanism safety evaluation |
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