Cause and manner of death among users of anabolic androgenic steroids

Medicolegally investigated deaths among 34 male users of anabolic androgenic steroids (AAS) are described. Nine persons were victims of homicide, 11 had committed suicide, 12 deaths were judged as accidental and 2 as indeterminate. In two cases of accidental poisoning, the levels of pharmaceuticals and illicit drugs were considered too low to be the sole cause of death and AAS was considered part of the lethal polypharmacia. Chronic cardiac changes were observed in 12 cases. In two cases of accidental poisonous deaths, these changes were regarded as contributory cause of death. Homicides, suicides, and poisonings determined accidental or indeterminate in manner were related to impulsive, disinhibited behavior characterized by violent rages, mood swings, and/or uncontrolled drug intake. The observations in the present study indicate an increased risk of violent death from impulsive, aggressive behavior, or depressive symptoms associated with use of AAS. There are also data to support earlier reports of possible lethal cardiovascular complications from use of AAS. Furthermore, a contributing role of AAS in lethal polypharmacia is suggested. Finally, the observations indicate that use of AAS may be the gateway of approach to abuse of other psychotropic drugs.     

Hair analysis and detectability of single dose administration of androgenic steroid esters

Detection of anabolic steroids in hair samples has been possible only in fatal cases or in cases of high-continuous dosages. In order to verify the possibility of detecting an acute administration, a sensitive and specific assay has been developed for the simultaneous determination of testosterone, nandrolone and some of their esters in hair. The analytes were extracted from finely cut hair with methanol-trifluoroacetic acid overnight. After the incubation, the mixture was evaporated to dryness, redissolved and extracted with hexane. The dried organic layer was silanised and analysed by GC-MS and GC-MS-MS. A sensitivity of at least 20 pg injected was obtained for all the analytes. In guinea pigs treated with a single intramuscular dose of 10 mg/kg nandrolone decanoate, neither nandrolone decanoate nor nandrolone were found in hair collected after 13 days, while both compounds were clearly detectable after four repeated doses (each dose every 3-4 days) of 20 mg/kg nandrolone decanoate. Neither nandrolone decanoate nor nandrolone could be detected in hair from a male healthy volunteer 1 month after treatment with 50 mg nandrolone decanoate, while his urine still tested highly positive for the main nandrolone metabolite (> 100 ng/ml). Testosterone esters could not be detected in hair of healthy subjects collected respectively 3, 2 and 1 month after a single intramuscular administration of 250 mg testosterone enanthate (five subjects), a single intramuscular coadministration of 25 mg testosterone propionate plus 110 mg testosterone enanthate (one subject), or a single oral administration of 120 mg testosterone undecanoate (three subjects). Otherwise, hair analysis revealed an increase of testosterone concentration corresponding to the period of treatment. Analysis of blood and urine samples confirmed the absorption of those compounds. At the sensitivity achieved by the present method, no detection of nandrolone, nandrolone decanoate nor testosteron esters in hair seems to be obvious after a single dose administration.     

Sudden cardiac death during exercise in a weight lifter using anabolic androgenic steroids: pathological and toxicological findings

A 21-year-old, previously healthy weight lifter collapsed during a bench press workout. He had taken anabolic androgenic steroids parenterally for the previous several months. Pertinent autopsy findings included marked cardiac and renal hypertrophy and hepatosplenomegaly, with regional myocardial fibrosis and focal myocardial necrosis. Nandrolone (19-nor-testosterone) metabolites were identified in postmortem urine. The possible etiologies of the cardiac findings are discussed.     

Attributions for episodes of marital aggression: The effects of aggression severity and alcohol use

This study examined attributions for husband to wife marital agression as a function of aggression severity and husbands' alcohol use. Subjects were a community sample of 117 wives and 109 husbands who reported an episode of serious physical aggression during a structured interview, conducted at one year of marriage. The results showed that husbands' attributions were influenced by both severity and alcohol use. In particular, sober husbands tended to blame their wives for severe aggression, but, unexpectedly, drinking husbands tended to assume responsibility for severe aggression. In contrast, wives' attributions were influenced mainly by severity. Wives also discriminated between the locus and stability dimensions of causal attributions, whereas husbands relied solely on the locus dimension. Specifically, wives held husbands' behavior more responsible for severe aggression than their own behavior and held husbands' character much more responsible than their own character. Additional findings with regard to relationship attributions were discussed.     

Violent crime and substance abuse: a medico-legal comparison between deceased users of anabolic androgenic steroids and abusers of illicit drugs

Several case reports and survey studies have indicated that abuse of anabolic androgenic steroids (AAS) often leads to increased aggressiveness and feelings of hostility that may occasionally trigger violent behaviour. Other observations indicate that many users of AAS also abuse alcohol and/or various illegal substances. Since substance abuse is a well-known risk factor for violent behaviour, it could be that violence committed by AAS users might, at least in many cases, actually be caused by abuse of other drugs. In order to examine this possibility further here, the criminal histories (in terms of incidences of convictions) of deceased users of AAS with (AASpos-subst.pos) and without (AASpos-subst.neg) signs of abuse of other illegal substances were compared to the corresponding histories of deceased users of illicit substances testing negatively for AAS (subst.pos-AASneg) at the time of autopsy. The risk of being convicted for a crime against property was significantly higher in the subst.pos-AASneg group than in either the AASpos-subst.neg or AASpos-subst.pos groups (RR=0.048 versus 0.408). At the same time, the risk of being convicted for a crime of violence was at least as high for the two AAS-positive groups as for the AAS-negative group. Furthermore, when compared with the first 3 years after the first criminal conviction, a pronounced increase in the proportion of incidence of violent crimes and a marked reduction in the proportion of incidence of crime against property was observed during the 3-year period immediately preceding death only among the AASpos-subst.neg subjects. In conclusion, the incidence of violent crime among users of AAS without signs of other drug abuse was comparable to the corresponding incidences for drug addicts without AAS use. This observation suggests that the violent criminality observed among AAS users is not confounded in any systematic fashion by abuse of other drugs. The findings also indicate that use of AAS in certain predisposed individuals might cause a high rate of violent crimes, especially if the use of AAS is combined with the use of other illegal substances.     

Morphofunctional changes of external male genitalia in alcoholism and substance abuse

The external male genitals (EMG) of male corpses, who abused alcohol and narcotics at lifetime, were examined. The objects were stained according to the common histological and histochemical methods. The study results are indicative of a high frequency rate of pathologic changes of the EMG in persons, who abused alcohol and narcotics at lifetime. The inflammatory, fibrosing and atrophic changes of the EMG as well as a reduced vascular permeability can be a cause for erection malfunction.     

Alcohol use in male spouse abusers and their female partners

Patterns of alcohol use of 181 maritally violent and maritally nonviolent men and their female partners differed on subscales of the Quantity-Frequency Index. Two abuser groups (43 uncounseled and 46 counseled) drank significantly greater amounts and for different psychological reasons than two nonabuser groups (50 satisfactorily married and 42 discordant). However, group frequency rates did not vary. The abuser groups had experienced and observed significantly more violence during childhood than the nonabuser groups; further, they reported significantly more current life stress. The female partners of the abusers did not differ in global alcohol use; however, they drank substantially more than their counterparts. They were especially prone to drink in response to battering. About one fourth of the abusers and one fifth of their wives drank frequently during abusive episodes. Stressors and depressors most likely precipitated both drinking and battering, with strain, hostility, and alcohol myopia (altered perception) serving as intervening variables. Results clarify contradictory reports concerning the role of alcohol in family violence.     

Co-occurring psychiatric and substance use disorders among male detainees in Italy

This paper presents data on the prevalence of co-occurring substance use and psychiatric disorders among newly imprisoned males in Italy. Interviewers conducted semi-structured clinical interviews with n = 302 male detainees seven days after their admission to the prison of Perugia from August 2005 through July 2006. Over half of male detainees (54.3%) had either a substance use disorder or another psychiatric disorder. One of every five detainees (20.9%) had comorbid substance use and psychiatric disorders. Compared to detainees with psychiatric disorder only, substance use disorder only, or no disorder, detainees with comorbid substance use and psychiatric disorders were significantly more likely to have severe impairment in the areas of employment, substance abuse, family and social functioning, and psychiatric symptoms. Findings underscore the need for careful diagnostic screening at intake, access to treatment during detention, and an effective transition to services at the time of release.     

Treating impulsivity, irritability, and aggression of antisocial personality disorder with quetiapine

There are few effective treatments of antisocial personality disorder (APD). Preliminary work suggests that the atypical antipsychotic quetiapine can decrease irritability, impulsivity, and aggressiveness. Data were collected from 4 patients with APD who were referred to a maximum-security inpatient psychiatric facility for pretrial evaluation and were treated with quetiapine. Quetiapine was effective in these patients as was indicated by a decrease in symptoms such as impulsivity, hostility, aggressiveness, irritability, and rage reactions. Typical dosage was 600 to 800 mg per day. Patients attributed their willingness to comply with quetiapine treatment to both the effectiveness of the drug and its favorable adverse-event profile. Quetiapine was successfully combined with mood stabilizers, particularly gabapentin, in patients with prominent affective instability. Quetiapine has demonstrated efficacy in aggression, impulsivity, and irritability and has proved to be an effective medication in these patients with APD. In addition, its favorable adverse-event profile makes patients willing to comply.     

Hostility and stress as mediators of aggression in violent men

This research investigated hypothesized differences on the Buss-Durkee Hostility Inventory between five groups of men who varied in terms of being violent toward female cohabitants, nonfamily members, or no one, and in terms of marital satisfaction. Other measures, such as stress and childhood abuse data, were employed to interpret the findings. A two-way MANCOVA (group by race) with six sociodemographic covariates revealed significant differences on three Hostility Inventory subscales. The maritally violent men had significantly higher total Hostility than any of the other groups and were significantly discriminable from the other groups. Nonetheless, the beliefs and behaviors of violence-prone individuals overlap to some degree. A cognitive-behavioral model with stimulus variables of life Stressors, intervening variables of hostility and negative stress reactions, and response variables of different forms of aggression served as a framework for interpreting the results.     

Age-specific changes in bone tissue microstructure and potential for use for human identification

The possibility of using the data of quantitative microscopy of bone tissue for evaluation of age with the aim of personality identification is discussed. Computer histomorphological analysis of third rib, tibial lower epiphysis and diaphysis fragments from 564 male corpses of known age (0-90 years) was carried out. A complex of parameters most strongly correlating with age was detected: extension of active osteogenesis zone in the longitudinal section of a rib, thickness of layers of internal and external general diaphyseal laminae in the tibial bone, trabecular area in the tibial epiphyseal preparation, etc. Age-specific changes in bone tissue structures is characterized by a great variety and depends on the type and location of these structures. Bone tissue characteristics change irregularly and asynchronously, therefore their correlations with age are different in different age groups. A general biological interpretation of the results is offered.     

Perception of family social climate and physical aggression in the home

Physical aggression between spouses is a serious social problem. This study was designed to determine if social climate is different in the homes where aggression occurs than in nonviolent homes. Students were asked to report whether physical aggression between spouses occurred in their homes during their last 2 years of high school. They were also asked to complete the Marlowe-Crowne Social Desirability Scale (MC-SDS) and the Family Environment Scale (FES). Each student protocol with reported conjugal violence was matched with another protocol with an identical score on the MC-SDS and on which physical aggression was not reported. A multivariate analysis of variance indicated that these two groups differed in their scores on the FES. A dominance hierarchy, openly expressed anger, conflict, and lack of organization were salient characteristics of homes where physical aggression occurred. Nonviolent families were characterized by spontaneous expression of feelings and problems, shared pleasurable activities and goals, and an emphasis on personal rights and freedoms.     

BOLD—fMRI在肇事肇祸精神分裂症研究中综述

综述了肇事肇祸精神病患者脑功能异常区以及异常区之间的相互关系。主要采用事件相关的图片线索诱导一中性线索反应模式的fMRI扫描,对司法鉴定为精神病患者进行的探索实验性研究。结果表明,双侧大脑额叶、颞叶区域存在多个脑功能激活区。因此,脑功能成像（fMRI）可以作为肇事肇祸精神病司法鉴定的一个有效手段。     

The use of microscopic postmortem changes in anagen hair roots to associate questioned hairs with known hairs and reconstruct events in two murder cases

In two cases investigated by the New Orleans Police Department Crime Lab, hairs recovered from crime scenes were found to exhibit microscopic postmortem changes in anagen hair roots. These microscopic characteristics were used to associate these hairs with various victims in the cases. In addition to associating questioned hairs with known hairs, the fact that the victims were dead when the hairs were pulled helped investigators reconstruct events in both crimes and corroborate statements made by the arrested subjects in each case.     

Identification and isolation of male cells using fluorescence in situ hybridisation and laser microdissection, for use in the investigation of sexual assault

In cases of sexual assault involving an azoospermic assailant, vaginal swabs taken from the victim may fail to provide an autosomal DNA profile with which to search a suspect database, as the signal from any male cells present would be masked by that from the overwhelming number of female cells collected on the swab. Here, we describe a method of visually identifying diploid male cells in such samples using fluorescence in situ hybridisation, and selectively harvesting them by means of laser microdissection. This combination of techniques was tested on 26 post-coital vaginal swabs taken at a range of times after intercourse; the collected cells were then subjected to a simple lysis procedure and DNA was amplified using the AmpFlSTR^® SGMPlus^® multiplex under low copy number conditions. Useful DNA profiles were generated from samples taken up to 24 h after intercourse.     

The role of beliefs and trait aggression in prison bullying among young offenders

This study aimed to explore the characteristics of those involved in bullying, including trait aggression, beliefs, interpretation of potential threat and responses to aggression. Three hundred and thirteen young adult male offenders completed three measures; the Direct and Indirect Prisoner Behaviour Checklist, the Aggression Questionnaire, and the Threat Appraisal of Behaviour measure. Pure bullies and bully-victims were predicted to have higher trait aggression scores, and to be more likely to endorse beliefs supportive of aggression than other groups. Bully-victims were predicted to have higher levels of trait hostility and higher levels of fear than pure bullies. The results demonstrated that both bully groups had higher trait aggression scores, with bully-victims having higher scores on the hostility subscale than pure bullies or those not involved. Bully-victims viewed bullying as more of a threat and were more fearful of it than pure bullies and they were also more likely to endorse both aggressive and avoidant coping responses whereas pure bullies were more likely to endorse aggressive responding. Findings highlight differences between the two bully groups and offers an outline of the underpinning causes of bullying for each group.     

警察形象危机与媒体公关对策

警察形象危机会使公安机关陷入巨大的舆论压力之中,并对警察的整体声誉造成严重损害。在危机状态下,媒体既是公安机关管理形象危机的对手,又是不得不与之合作的对象。因此,公安机关在形象危机事件中,应针对危机不同发展阶段的特点以及媒体不同时期行为的特征,运用一系列可实际操作的对策,积极开展警察形象危机媒体公关,以期通过与媒体的合作,最大限度地控制和化解危机,维护公安机关的形象。