The attack of the clones: patent law and stem cell research

This article considers the integral role played by patent law in respect of stem cell research. It highlights concerns about commercialization, access to essential medicines and bioethics. The article maintains that there is a fundamental ambiguity in the Patents Act 1990 (Cth) as to whether stem cell research is patentable subject matter. There is a need to revise the legislation in light of the establishment of the National Stem Cell Centre and the passing of the Research Involving Embryos Act 2002 (Cth). The article raises concerns about the strong patent protection secured by the Wisconsin Alumni Research Foundation and Geron Corporation in respect of stem cell research in the United States. It contends that a number of legal reforms could safeguard access to stem cell lines, and resulting drugs and therapies. Finally, this article explores how ethical concerns are addressed within the framework of the European Biotechnology Directive. It examines the decision of the European Patent Office in relation to the so-called "Edinburgh patent", and the inquiry of the European Group on Ethics in Science and New Technologies into "The Ethical Aspects of Patenting Involving Human Stem Cells".     

安徽东辰集团：30亿元借款缺失之谜

安徽东辰集团与北京恒泰基业之间的3亿元“借款”，纠篁了堕界和政界一群人的利益，但其幕后主使仍然没看露出真面目     

INTERNET CONTENT REGULATION: Concerns from a European User Empowerment Perspective about Internet Content Regulation: an Analysis of some recent Statements — Part I

This article, to be published in two parts, explores the debate between the Bertelsmann Foundation and the Centre for Democracy and Technology about regulation on illegal and harmful content on the Internet. The authors intend to analyze the method, interests and limits of the self regulatory model proposed by the European institutions, bearing in mind the users’ empowerment perspective.     

Forensic textile fiber examination across the USA and Europe.

Crime laboratories in the USA, who undertake fiber examinations, together with members of the European Fibres Group (plus representatives from Israel, Japan, Canada, and Australia) were surveyed in 1994 and 1995, respectively, and asked to provide subject-specific information relating to personnel, equipment, training, quality control, and techniques available. The information obtained showed that generally more fiber casework is carried out in Europe than in the USA. Most laboratories are quite well equipped but those in Europe seem to be able to obtain more state-of-the-art instrumentation. Proficiency testing and peer review is accepted practice worldwide. Americans appear to update fiber collections on a more regular basis than Europeans but both keep literature up to date. Contamination is a major issue, as with all areas of trace evidence. The results from the survey suggest that minimum standards are clearly not always being observed. Careful consideration also needs to be given as to whether legitimate contact could have occurred prior to an offense being committed. The standard of forensic fiber examination worldwide is generally high. With laboratory management continuing to support the work of the Scientific Working Group for Materials and the European Fibres Group and by instigating "best practice" as set out in their guidelines, standards should continue to improve.     

ENFSI collaborative testing programme for ignitable liquid analysis: a review

The Fire and Explosion Investigation Working Group of the European Network of Forensic Science Institutes (ENFSI) is the organiser of a collaborative testing programme for ignitable liquid analysis. The testing programme was initiated in 1998. Initially to inventory the analytical methods used in this field of analysis, but with the ultimate goal to establish a European testing programme for fire debris analysts. As of today, five tests have been conducted. This article will provide an overview of the first five ENFSI collaborative tests for ignitable liquid analysis. The background, objectives and characteristics of the testing programme are summarised, followed by an overview of the sample composition employed, the participants' performance, the difficulties and the lessons learned in each test.     

Restating the Acquis Communautaire? A Critical Examination of the ‘Principles of the Existing EC Contract Law’

The article examines the 'Principles of the Existing EC Contract Law' (Acquis Principles) published by the European Research Group on the Existing EC Contract Law (Acquis Group), a key player within the academic network charged with the preparation of a 'Common Frame of Reference'. The Acquis Principles may therefore have a considerable impact on the shape and development of EC Contract Law. It is argued that the Acquis Principles do not constitute merely a restatement, or systematic revision, of existing EC private law. To a significant extent, the Acquis Group has drafted 'desirable rules', based on 'political' decisions that may even entail a transformation towards a regulatory model of private law. At the same time, the Acquis Principles clearly demonstrate that the acquis communautaire is not a coherent system of contract law that can be taken to have emancipated itself from the acquis commun .     

Application of Cameriere’s method for dental age estimation in children in South China

The aim of this study was to evaluate the applicability of Cameriere’s European formula for age estimation in children in South China and to adapt the formula to establish a more suitable formula for these children. Moreover, the performance of dental age estimation based on Cameriere’s method combining the developmental information of permanent teeth (PT) and third molar (TM) was also analysed. Orthopantomographs of 720 healthy children in Group A, and orthopantomographs of 320 children and 280 subadults in Group B were assessed. The samples of Group A were divided into training dataset 1 and test dataset 1, and the samples of Group B were also divided into training dataset 2 and test dataset 2. A South China-specific formula was established based on the training dataset 1, and the comparison of accuracy between the Cameriere’s European formula and the South China-specific formula was conducted with the test dataset 1. Additionally, a PT regression model, a TM regression model, and a combined regression model (PT + TM) were established based on the training dataset 2, and the performance of these three models were validated on the test dataset 2. The Cameriere’s European formula underestimated chronological age with a mean difference (ME) of −0.47 ± 1.11 years in males and −0.69 ± 1.19 years in females. However, the South China-specific formula underestimated chronological age, with a mean difference (ME) of −0.02 ± 0.71 years in males and −0.14 ± 0.73 years in females. Compared with PT model and TM model, the PT and TM combined model obtained the smallest root mean square error (RMSE) of 1.29 years in males and 0.93 years in females. In conclusion, the South China-specific formula was more suitable for assessing the dental age of children in South China, and the PT and TM combined model can improve the accuracy of dental age estimation in children.

Key points

• Orthopantomographs of 720 healthy children in Group A, and orthopantomographs of 320 children and 280 subadults in Group B were assessed.
• A South China-specific formula was established based on the training dataset 1, and the comparison of accuracy between the Cameriere’s European formula and the South China-specific formula was conducted with the test dataset 1.
• A PT regression model, a TM regression model, and a combined regression model (PT + TM) were established based on the training dataset 2, and the performance of these three models were validated on the test dataset 2.
• The South China-specific formula was more suitable for assessing the dental age of children in South China, and the PT and TM combined model can improve the accuracy of dental age estimation in children.

     

The evolution of European legal integration

This article contributes to the development of theories on European integration by testing and exploring statistical models on the long-term development of legislative activity of the European Commission. Drawing on legal information gained from the European Union’s PreLex database and analyzing it with the help of statistical analyses, we map out growth patterns of EU law between 1976 and 2003. We construct time-series models and models based on non-linear regression. While the performance of models based on the traditional theoretical approaches, intergovernmentalism and neo-functionalism, is rather poor, the analysis suggests that nonlinear dynamic models might be an interesting avenue for future conceptualizations of the EU integration process. This article is based on a paper presented at the ECPR Standing Group on the European Union Second Pan-European Conference on EU Politics, “Implications of a Wider Europe: Politics, Institutions and Diversity”, 24–26 June 2004, Bologna, Italy. We would like to thank the seminar participants for useful comments.     

Results of a collaborative study of the EDNAP group regarding the reproducibility and robustness of the Y-chromosome STRs DYS19, DYS389 I and II, DYS390 and DYS393 in a PCR pentaplex format

A collaborative exercise was carried out by the European DNA Profiling Group (EDNAP) in the frame work of the STADNAP program, i.e. standardization of DNA profiling in Europe, in order to evaluate the performance of a Y-chromosome STR pentaplex, which includes the loci DYS19, DYS389 I and II, DYS390 and DYS393 and to determine whether uniformity of results could be achieved among different European laboratories.Laboratories were asked to analyze the five Y-STRs using singleplex and multiplex conditions in three bloodstains and one mixed stain (95% female and 5% male).All the laboratories reported the same results even for the mixed stain included in the exercise. This demonstrates the reproducibility and robustness of Y-chromosome STR typing even with multiplex formats and proves the usefulness of Y-STR systems for analyzing mixed stains with a male component.A total of 930 male samples from 10 different populations from Europe were also analysed for all the loci included in the pentaplex. Eight of these ten populations also included haplotype data.As for single gene analysis, haplotype diversity was higher in Germany and Italy and lower in Western European countries and Finland.Pairwise haplotype analysis shows the Finnish departure from the rest of the populations and a relatively homogeneity in the other European populations with F(ST) estimates lower than 0.05.UPGMA analysis shows an association of Western European population (Ireland, UK, Portugal and Galicia) on the one hand and central European populations on the other.     

REVIEWS

Legal Services in Birmingham . By Lee Bridges , Brenda Sufrin , Jim Whetton and Richard White . Legal Expense Insurance . By Werner Pfennigstorf . [Chicago: American Bar Foundation. 1975. ix and 117 pp. $3.00.] The Land and the Development , or The Turmoil and the Torment . By Sir Desmond Heap ; being the 27th series of the Hamlyn lectures. Compensation for Compulsory Purchase : A Comparative Study. Edited by J. F. Garner . Compensation for Compulsory Purchase Landlord and Tenant . By M. Partington Kemp and Kemp : The Quantum of Damages in Personal Injury and Fatal Accident Claims . By David A. Mc I. Kemp, q.c. , assisted by Derrick Turriff , John M. C. Moxom and Richard W. Seymour . Compensation and Rehabilitation . By Harold Luntz . Bullen an D Leake and Jacob's Precedents of Pleadings . Twelfth edition. By I. H. Jacob . Odgers ' Principles of Pleading and Practice . Twenty-first edition. By D. B. Casson and I. H. Dennis . The European Convention on Human Rights . By Francis G. Jacobs . The European Convention on Human Rights . By Fredr . Casteberg . European Community Law in the United Kingdom . By Lawrence Collins . Compendium of Case Law Relating to the European Communities 1973. By H. J. Eversen , H. Sperl , and J. A. Usher . Megarry's Manual of the Law of Real Property . Fifth ed. By P. V. Baker . A Practical Guide to Capital Transfer Tax . By Hilda Wilson .     

A collaborative study of the EDNAP group regarding Y-chromosome binary polymorphism analysis

A collaborative study was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the performance of Y-chromosome binary polymorphism analysis in different European laboratories. Four blood samples were sent to the laboratories, to be analysed for 11 Y-chromosome single nucleotide polymorphisms (SNPs): SRY-1532, M40, M35, M213, M9, 92R7, M17, P25, M18, M153 and M167. All the labs were also asked to submit a population study including these markers. All participating laboratories reported the same results, indicating the reproducibility and robustness of Y-chromosome SNP typing. A total of 535 samples from six different European populations were also analysed. In Galicia (NW Spain) and Belgium, the most frequent haplogroup was R1b*(xR1b1,R1b3df). Haplogroup F*(xK) is one of the most frequent in Austria and Denmark, while the lowest frequency appear in Belgium. Haplogroup frequencies found in this collaborative study were compared with previously published European Y-chromosome haplogroup data.     

Crime Trends in Western Europe from 1990 to 2000

This paper analyses the evolution of police recorded crime rates for nine offences (intentional homicide, assault, rape, robbery, theft, vehicle theft, burglary, domestic burglary, and drug offences) over the period 1990–2000 in 16 Western European Countries. The analysis shows that there was an increase in drug and violent offences, while property offences reached a peak at the beginning of the 1990s and started decreasing afterwards. The evolution of property offences can be related to the emergence of a large black market for stolen goods in Central and Eastern Europe at the beginning of the time series, while by the end of it that market was saturated and there had also been a reinforcement of police measures in the frontiers and of security measures in Western European households. The increase in drug offences is correlated to the rise of drug use in Europe shown by other indicators, and can be related to an increased availability of drugs in European markets. Finally, the upward trend in violent offences can be explained partially by gang struggles over the control of illegal markets and by the consolidation of problematic neighbourhoods, but seems also due to a large extent of increase in the reporting of violent offences by their victims and the recording of such offences by the police. The analysis shows that opportunity-based theories provide a satisfactory explanation of the trends in recorded crime, and that the crime opportunities are heavily influenced by socio-economical factors.Versions of this paper were presented at the 3rd Annual Conference of the European Society of Criminology (Helsinki, August 27–30, 2003) and at the Societies of Criminology 1st Key Issues Conference (Paris, May 13–15, 2004). The paper was written during a stay at the Max Planck Institute for Foreign and International Criminal Law (Freiburg imBreisgau, Germany) made possible through the support of Swiss National Science Foundation     

Urban Change and Policing: Mass Private Property Re-considered

This article examines a key explanation for the growth of private policing in North America and Western Europe - the influential mass private property thesis (Shearing and Stenning 1981). The discussion of private policing in Western Europe still tends to be heavily influenced by theories developed in the North American context, theories which may be problematic in the contrasting legal, social and economic contexts of Western European nations. The development of more Eurocentric theories has to date been inhibited by the relative paucity of empirical data on the rise of private policing in European countries. Recent research in Britain (Jones and Newburn 1998b) has begun to address this problem, and to map out some important contrasts with the North American experience. By considering these contrasts, it is possible to identify some key areas for future research on private policing in European countries and thus provide a more contextually-grounded series of explanations for what is happening to policing.Joseph Rowntree Foundation Professor of Urban Social Policy     

Fibre mapping--a case study.

Fibre mapping, more commonly known as one-to-one taping, was developed in Germany approximately twenty years ago. The technique facilitates the distribution of fibres on a surface to be recorded. The impact of this technique on the investigation of serious crime has been reported in the European Fibre Group on several occasions. This paper represents a case study of the application of the technique. It is believed to be the first time that this technique has been successfully applied in the United Kingdom.     

Evaluation of ninhydrin as a fingermark visualisation method – A comparison between different procedures as an outcome of the 2017 collaborative exercise of the ENFSI Fingerprint Working Group

In 2017 the Fingerprint Working Group (EFP-WG) of the European Network of Forensic Science Institutes (ENFSI) undertook a collaborative exercise (CE) with the aim of assessing the use of ninhydrin as a fingermark development technique in the laboratory. The test was prepared and managed by the officially established advisory group. The characteristics of the CE are summarised. The results indicate that ninhydrin is a robust methodology. Unexpected negative outcomes have been outlined and discussed, followed by an overview of the knowledge that has been gained.     

Analysis of artificially degraded DNA using STRs and SNPs--results of a collaborative European (EDNAP) exercise

Recently, there has been much debate about what kinds of genetic markers should be implemented as new core loci that constitute national DNA databases. The choices lie between conventional STRs, ranging in size from 100 to 450 bp; mini-STRs, with amplicon sizes less than 200 bp; and single nucleotide polymorphisms (SNPs). There is general agreement by the European DNA Profiling Group (EDNAP) and the European Network of Forensic Science Institutes (ENFSI) that the reason to implement new markers is to increase the chance of amplifying highly degraded DNA rather than to increase the discriminating power of the current techniques. A collaborative study between nine European and US laboratories was organised under the auspices of EDNAP. Each laboratory was supplied with a SNP multiplex kit (Foren-SNPs) provided by the Forensic Science Service, two mini-STR kits provided by the National Institute of Standards and Technology (NIST) and a set of degraded DNA stains (blood and saliva). Laboratories tested all three multiplex kits, along with their own existing DNA profiling technique, on the same sets of degraded samples. Results were collated and analysed and, in general, mini-STR systems were shown to be the most effective. Accordingly, the EDNAP and ENFSI working groups have recommended that existing STR loci are reengineered to provide smaller amplicons, and the adoption of three new European core loci has been agreed.     

Criteria for Evaluation of Burden-sharing Rules in International Climate Policy

This article presents nine criteria for assessing, comparing, and ranking burden-sharing rules and conceptual frameworks used in climate policy negotiations and agreements. Three of the criteria are concerned with fairness principles and six criteria are operational requirements. The application of these criteria is illustrated in the context of six different burden-sharing schemes. The Multi-sector Convergence approach and the Triptych approach received highest average score of the six schemes. The Brazilian proposal received a similar total score, but unevenly distributed with a high score on fairness principles and low score on operational requirements. The European Union member countries employed the Triptych approach when they differentiated their national abatement targets prior to the 1997 Kyoto meeting. The Multi-sector Convergence approach was developed in a joint ECN (Netherlands Energy Research Foundation) and CICERO (Center for International Climate and Environmental Research – Oslo) project. It is a sector-based, global approach that comprises convergence of per capita emissions at the same level in all countries. Sector-based approaches have a distinct advantage compared to other approaches because they reflect the economic structure of countries rather well. Such approaches could play a useful role in future climate policy negotiations, not the least in discussions on binding climate targets for developing countries.     

Breaking the chainlinks of poverty: strategies for social justice

Thanks to support from the Joseph Rowntree Foundation, the Centre for Crime and Justice Studies produced an evidence review on the links between poverty and institutional care, summarised in a collection of reviews published by the Foundation (Grimshaw et al., 2014; Joseph Rowntree Foundation, 2014).     

Y-STR analysis on DNA mixture samples—Results of a collaborative project of the ENFSI DNA Working Group

The ENFSI (European Network of Forensic Science Institutes) DNA Working Group undertook a collaborative project on Y-STR typing of DNA mixture samples that were centrally prepared and thoroughly tested prior to the shipment. Four commercial Y-STR typing kits (Y-Filer, Applied Biosystems, Foster City, CA, USA; Argus Y Nonaplex, Biotype, Dresden, Germany; Powerplex Y, Promega, Madison, WI, USA; and DYSplex-3, SERAC, Bad Homburg, Germany) were used for the amplification of the mixture samples. The results of the study showed a striking inter-laboratory difference of kit performance as determined from the peak heights of the obtained Y-STR genotypes. Variation in quantity and quality of the shipped DNA can be excluded as reason for the observed differences because both samples and shipping conditions were found to be reproducible in an earlier study. The results suggest that in some cases a laboratory-specific optimization process is indicated to reach a comparable sensitivity for the analysis of minute amounts of DNA.     

Population genetic data for 17 non-CODIS STR loci for the Saudi Arabian population using the SureID®23comp Human Identification Kit

Our previous work focused on validation the SureID 23comp Human Identification Kit (Health Gene Technologies, China), following the minimum criteria for validation recommended by the European Network of Forensic Science Institutes (ENFSI) and the Scientific Working Group on DNA Analysis Methods (SWGDAM) using 500 samples from the population of Saudi Arabia. The kit genotypes 22 STRs, 17 of which are non-CODIS, and Amelogenin. The validation tests showed that it has the potential to increase the power of testing in complex cases.In this paper, the allele frequency data, common forensic parameters for the 17 non-CODIS STR loci are presented. We found the majority of loci had an excess of homozygosity in the data set, which is most likely explained by the relatively high levels of consanguinity in the population of Saudi Arabia.