GC–MS analysis of eight aminoindanes using three derivatization reagents

Aminoindanes are a class of novel psychoactive substances (NPSs) that have become more prevalent over the past decade. GC–MS is often utilized for identifying seized drugs and is well regarded for its ability to separate mixtures. However, certain aminoindanes have similar mass spectral data and require specific gas chromatographic stationary phases for separation. Derivatization is an alternative method that can be applied to GC–MS to enhance chromatographic results, providing more selective analysis in seized-drug identification. This study investigates derivatization techniques to provide options for forensic science laboratories in accurately identifying aminoindanes. Three derivatization reagents, N-methyl-bis(trifluoroacetamide) (MBTFA), heptafluorobutyric anhydride (HFBA), and ethyl chloroformate (ECF) were evaluated for the analysis of eight aminoindanes by GC–MS using two common gas chromatographic stationary phases, Rxi®-5Sil MS and Rxi®-1Sil MS. All three derivatization methods successfully isolated eight aminoindanes, including the isomers 4,5-methylenedioxy-2-aminoindane (4,5-MDAI), and 5,6-methylenedioxy-2-aminoindane (5,6-MDAI) that could not be differentiated prior to derivatization. Reduced peak tailing and increased abundance were observed after derivatization for all the compounds, and mass spectra of the derivatives contained individualizing fragment ions that allowed for further characterization of the aminoindanes. This excluded 4,5-MDAI and 5,6-MDAI as they shared the same characteristic ions and were only distinguishable by their retention times. All three derivatization techniques used in this study allow for successful characterization of the aminoindanes and give forensic science laboratories flexibility in their analysis approach when they encounter these compounds.     

Dynamics of latent fingerprints: The effect of physical factors on quality of ninhydrin developed prints — A preliminary study

The conditions under which latent fingerprints are deposited affect the process of development that can be used to effectively recover these marks. The conditions which can play a part include environmental conditions, the type of surface on which latents are deposited, the ability of the donor to deposit fingerprints, contact time, force of contact with the object etc. Very little previous work is available in the scientific literature addressing these conditions and therefore, an attempt has been made in this present study to assess the effect of some of these criteria and their effect on the ability of ninhydrin to develop the marks. Latent fingerprints from good and bad donors were obtained on paper with variable pressure under controlled conditions. Laboratory prepared 1% ninhydrin solution was used to visualise the prints.     

Evaluation of genetic markers for the analysis of THC levels of Cannabis sativa samples using principal component analysis – A preliminary study

Cannabis sativa is a worldwide commercial plant used for medicinal purposes, food and fiber production, and also as a recreational drug. Therefore, the identification and differentiation between legal and illegal C. sativa is of great importance for forensic investigations. In this study, principal component analysis (PCA), an exploratory data analysis technique, was tested to correlate the specific genotype with the concentration of tetrahydrocannabinol (THC) in the samples. C. sativa samples were obtained from legal growers in Piedmont, Italy, and from illegal drug seizures in the Turin region. DNA was extracted, quantified, amplified with a 13-loci multiplex STR and finally analyzed with an automated sequencer. The results showed a trend in the analyzed samples as they differed by their THC content and allele profiles. PCA yielded two clusters of samples that differed by specific allele profiles and THC concentrations. Further validation studies are needed, but this study could provide a new approach to forensic investigation and be a valuable aid to law enforcement in significant marijuana seizures or in tracing illicit drug trafficking routes.     

Is the length of the sternum reliable for estimating adult stature? A pilot study using fresh sterna and a test of two methods using dry sterna

Stature estimation is one of the four attributes of the biological profile obtained from human skeletal remains. The length of the long bones has been consistently used to estimate stature from regression equations, but these may be useless when dealing with fresh or decomposed mutilated remains. Until recently, there was no consistent assessment of the reliability of measurements of the sternum for stature estimation. The purpose of this paper is to test previously developed regression formulae for stature based on measurements of the dry sternum and to assess the reliability of measurements of the fresh sternum in estimating stature. The formulae developed by Menezes et al. and Singh et al. were applied to a sample of 5 known stature skeletons from the identified human skeletal collection curated at the National Museum of Natural History, in Lisbon, Portugal. Testing of these formulae showed that estimated stature confidence intervals do not allow discrimination between individuals with similar stature. The length of the fresh sternum was measured on a sample of 45 male individuals autopsied at the National Institute of Legal Medicine - North Delegation (Porto, Portugal). Cadaver length was regressed on sternum length and a simple linear regression formula was obtained. The regression model provided a 95% confidence interval of 13.32 cm and a correlation coefficient of only 0.329. Compared to other studies, regression formulae based on the length of the sternum provided considerably larger standard errors than that based on long bone lengths. These results suggest that the length of the sternum has limited forensic value and relatively low reliability in estimating stature from mutilated human skeletal remains, either skeletonized or fresh.     

Will the introduction of an emotional context affect fingerprint analysis and decision-making?

Fingerprint identification relies on an expert's ability to accurately recognise differences and similarities in friction ridge detail. The process is open to the questioning of an expert's ability to accurately analyse and interpret friction ridges. It has been suggested that the interpretation and analysis of fingermarks becomes more subjective as clarity decreases and as a consequence the expert is more vulnerable to external stimuli. An experiment involving 70 fingerprint experts was conducted to establish whether the introduction of an emotional context would alter the experts' judgement of an ambiguous or poor quality mark. The emotional context did have a perceived effect on the experts' analysis, as more stated they were affected by the information they were given. However, it did not have any actual effect on their final opinions as no difference was observed between the high- and low-emotional contexts.     

Can a prison be self-managed? A study of the informal organisation of a bolivian prison

The purpose of this study is to investigate the unique prisons of Bolivia. Their main features include the presence of wives and children, self-management of activities within the prison and the opportunity for inmates to take part in various activities. In particular, the general organisation of the prisons and the inmates’ experience, especially on an interpersonal level, is described in this study. The obtained data shows that functional and effective experiences of social rehabilitation can be promoted even under extreme conditions and, in some cases, this provides important insights into the prison systems of most developed countries.

     

Who are the people in your neighborhood? A descriptive analysis of individuals on public sex offender registries

Despite growing focus on registration and notification systems as central elements of national sex offender management practice, there has been remarkably little systematic analysis of the content of these registries and the diversity of individuals contained within them. Specifically, little research attention has been paid to examining the heterogeneity of the population of registered sex offenders — a circumstance that may obscure important distinctions within the population and, in turn, may undermine the ostensible purpose of SORN to prevent sexual victimization. Addressing this significant gap in our current knowledge, this article sets forth a national profile of the registered sex offender (RSO) population, drawn from an analysis of data on 445,127 RSOs obtained from the public registries of 49 states, Washington, DC, Puerto Rico and Guam. In contrast with the homogenized perception about registered sex offenders that permeates much public discourse, the analysis illuminates the wide diversity of registrants across a range of demographic, offense-related, registry status, and risk-oriented variables. Policy and practice implications concerning risk, prevention, and the public safety utility of sex offender registries are discussed.     

A study of the psychosexual characteristics of sex killers: can we identify them before it is too late?

Thirty-three sex killers were compared to 80 sexual aggressives, 23 sadists, and 611 general sex offenders on sexual history and preferences, substance abuse crime, violence, mental illness, personality, neurological and endocrine abnormalities. Compared to other groups, sex killers started their criminal careers earlier, more often had been to reform school, were members of criminal gangs, set fires, and were cruel to animals. They tended so show more sadism, fetishism, and voyeurism. They more often collected pornography, but they did not use it in their offenses. They more often abused drugs and some suffered from drug induced psychoses. Their most common diagnosis was antisocial personality disorder, but only 15.2% met criteria for psychopathy. Sex killers showed most signs of neuropsychological impairment, grades failure, and learning disabilities. Results suggest that greater emphasis be placed on studying adolescent sex offenders and conduct disordered children which may help identify potential sex killers.     

Evaluation of portable gas chromatography–mass spectrometry (GC–MS) for the analysis of fentanyl,fentanyl analogs,and other synthetic opioids

Potent synthetic opioids including fentanyl and its analogs are frequently encountered in the field and require detection and identification by first responders to maintain the safety of drug abusers, first responders, health-care providers, and the public at large. Due to the low concentration at which these substances may be encountered and the complicating matrices within which they may be dispersed, the use of portable gas chromatography–mass spectrometry (GC–MS) for their identification in the field offers great potential value. This research established that portable GC–MS is a useful method for the detection and identification of a large number of synthetic opioids, especially fentanyl and its analogs. In this study, 250 synthetic opioids and related substances including 210 fentanyl analogs were analyzed using portable GC–MS. It was concluded that 225 of the 250 (90.0%) opioids analyzed were successfully detected onboard at the time of analysis and identified as either the substance (55.2%) or an analog (34.8%). These outcomes have equivalent benefit for the field analysis of illicit drugs due to both initiating the same subsequent actions by first responders.     

Development of gas chromatography–mass spectrometry (GC–MS) and other rapid screening methods for the analysis of 16 ‘legal high’ cathinone derivatives

The prevalence of so-called ‘legal high’ drugs in forensic science drug casework has increased markedly in recent years. This has given rise to both legal and analytical challenges in the identification of these substances. The requirement for validated, reliable and rapid testing methodologies for these compounds is obvious. This work reports the analysis of sixteen synthesised cathinone derivatives encountered in casework using presumptive testing, thin layer chromatography and gas chromatography–mass spectrometry (GC–MS).     

Does image editing improve the quality of latent prints? An analysis of image-editing techniques in one crime laboratory

Field research within latent print comparison has remained sparse in the context of an otherwise growing body of literature examining the discipline. Studies examining how ACE-V procedures are implemented within active crime laboratories are especially lacking in light of research suggesting significant variability in examiner practices despite standardized ACE-V procedures. To date, no studies have examined a potentially important aspect of the Analysis phase: digital image editing. We provide information on the prevalence and types of latent print image editing within one laboratory (i.e., Houston Forensic Science Center), examine the potential effect of image editing on objective print quality and clarity (i.e., LQMetrics scores), and explore potential examiner differences in editing effectiveness. Results indicate that most latent prints are edited in some manner, and that image editing improves the quality and clarity of print images as defined by an objective quality metric, although examiners varied in their ability to improve the clarity of print images. Findings suggest that formal guidance or documentation of standard editing procedures would likely improve the reliability of examiner conclusions early in the latent print comparison process.     

Analysis of some commonly found inhalants using gas chromatography-mass spectrometry (GC MS) – Effect of substrates on the identification of inhalants

Inhalant abuse is a serious and ever-evolving problem for our society. Inhalants are abused more commonly by teenagers and adolescents. Inhalants such as glue, paint thinners, correction fluid, and nail paint remover are easily available in the market which makes them readily abused. Out of various methods of abuse, huffing (placing a piece of cloth soaked with inhalant is placed in the mouth), bagging (placing head in a polythene bag containing inhalant), and ballooning (balloons filled with inhalant are used for inhaling vapors through the mouth) are most common. Inhalant abuse results in multiple target organ dysfunction with neuritis and brain damage due to the dissolution of the myelin sheath. In acute poisoning cases, it might cause death due to asphyxia and sudden sniffing syndrome. In such cases, various articles containing traces of inhalants could be retrieved from the scene of incidence and to detect these traces become an important facet of the investigation. However, it might be difficult due to the rapid evaporation of inhalants and the formation of reaction product species. In the present study, an attempt has been made to study the effect of three substrates (balloon, cloth, polythene) on component profiles of four paint thinners and four nail paint removers. The study suggests that although some components are retained, there is the formation of a large number of reaction product species and these must be taken into consideration before furnishing the opinion. These reaction product species might also be inhalant specific which must be further explored.     

A follow-up study of sex offenders treated by Thames Valley Sex Offender Groupwork Programme, 1995–1999

The following paper is a reconviction study of 183 sex offenders treated by the Thames Valley Project between 1995 and 1999. Some demographic details are provided about the sample. Subjects were monitored for a mean of 3.9 years. A total of 10 subjects (5.4% of total) were reconvicted for a further sexual offence. A further 19 men (10.3%) either had allegations made against them or committed a behaviour that may have involved or been the preparation for further sexual offending, defined here as “recidivism”. Details about post-treatment behaviour were drawn from three sources: two national police databases which indicated any formal sexual reconviction and the files kept on each sex offender registered with Thames Valley Project (TVSOGP), a multi-funded community-based sex offender treatment programme. The pre-treatment re-conviction risk status of each man was calculated using part one of the Risk Matrix 2000 algorithm (static factors). Risk levels were compared for those where reconviction, re-offending or recidivism was identified and those where it was not and a correlation was found in the predicted direction although this was not statistically significant. The advantages and limitations of this kind of follow-up study are discussed, together with some recommendations for future research.     

IsTeen Court effective for repeat offenders? A test of the restorative justice approach

Teen Courts are an effective judicial alternative for many youth offenders. The majority of youth courts deal solely with first-time offenders. However, repeat offenders are at a greater risk for future crime. Is Teen Court effective with more experienced offenders? In this study, the authors examine the outcomes of 26 Whatcom County Teen Court offenders with at least one prior conviction. The sentence completion rate was higher and the recidivism was lower for the Teen Court offenders when compared with a sample of first-time Court Diversion offenders. This objective evidence of program success is augmented by an offender's perspective on his or her court experience. These perspectives as well as the continued voluntary involvement with Teen Court are discussed in relation to empowerment theory.     

Revisiting broken windows theory: A test of the mediation impact of social mechanisms on the disorder–fear relationship

PurposeBroken windows theory predicts that disorder signals a lack of neighborhood control, sparks fear of crime, and sets off a chain reaction ultimately resulting in crime. Support has been found for the disorder–fear link, but the present study argues that this link is actually intended to be indirect—perceived loss of control is what should cause fear.MethodsHierarchical linear models and structural equation models test four hypotheses regarding whether social cohesion and expectations for social control mediate the disorder–fear relationship.ResultsResults support partial mediation.ConclusionResults suggest confirmation of a portion of broken windows theory, in that disorder may inspire fear partially as a result of its detrimental impact on neighborhood cohesion and shared expectations for social control.     

Kin terminology and the study of kinship: A case study on the Greek island of Syros (1750–1820)

This historical–anthropological study of kinship on the Greek island of Syros examines kin terminology as an indicator of relationships. These terms have been traced in a series of notarial acts dating from 1750 to 1820. Departing from the case study, certain elements of the system of kin terminology have been placed in a broader territorial and cultural context. The aim of this comparative analysis is to achieve a deeper understanding of kinship on the microlevel of the case study. From a methodological point of view, this article points out the need for interdisciplinary research on kinship. History, social anthropology, and ethnology could be possible partners in such an approach.     

Is marijuana really a gateway drug? A nationally representative test of the marijuana gateway hypothesis using a propensity score matching design

Journal of Experimental Criminology - Marijuana use has been proposed to serve as a “gateway” that increases the likelihood that users will engage in subsequent use of harder and more...     

Breaking the cycle demonstration project: using a quasi-experimental analysis to test the “worst of both worlds” hypothesis and risk principle

Objectives

The purpose of this study was to test the “worst of both worlds” hypothesis and the risk principle in a sample of drug-involved offenders enrolled in the Breaking the Cycle (BTC) demonstration project, an intensive drug intervention implemented in Birmingham, Alabama, Jacksonville, Florida, and Tacoma, Washington.

Methods

A group of 1081 drug-involved offenders enrolled in BTC were compared to 934 drug-involved offenders (pre-BTC) who processed through the regular court system of each city 1 year prior to implementation of BTC. Participants from both groups were divided into risk levels based on scores from the Addiction Severity Index (ASI) Drug (D) and Legal (L) scales. Individuals who scored at or above the mean on both the ASI-D and ASI-L were identified as high risk, individuals who scored at or above the mean on either the ASI-D or ASI-L but not both were identified as moderate risk, and individuals who scored below the mean on both the ASI-D and ASI-L were identified as low risk.

Results

Consistent with the risk principle, high-risk BTC participants displayed significant improvements in subsequent drug problem days, criminal offending, and days spent in jail relative to high-risk pre-BTC participants. There was no apparent benefit of BTC enrollment for moderate- and low-risk participants.

Conclusions

These results indicate that drug–crime comorbidity can be used to assess risk and that individuals identified as high risk are more likely to benefit from higher-intensity forms of intervention than moderate- or low-risk individuals.