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全血中度冷丁的气—联用法测定及代谢动力学的研究 总被引:1,自引:0,他引:1
应用气-质联用选择离子法测定全血中度冷丁的浓度。方法线性范围为0.002~1ng/ml(r=0.9997),变异系数小于10%,最低检测限过1ng/ml,无杂质干扰。本法已用于肌注80mg度冷丁后代谢动力学的研究。 相似文献
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酒精对乌头碱毒物动力学的影响 总被引:2,自引:0,他引:2
用反相高效液相色谱法测定生物样品中的乌头碱.给新西兰兔灌服1.5g/kg短柄乌头后,乌头碱在免休内的毒物动力学过程为二室开放模型,其Ka、A、B值分别为1.1629±0.4053,0.6046±0.2574,1.1607±0.3781ug/ml.研究了灌服5.75g酒精对该动力学过程的影响,表明酒精不改变其模型类型,但可明显加速乌头碱的吸收和分布(P<0.01),对消除过程无明显影响,其Ka、A、B值分别为2.4026±0.5376,1.2051±0.5328,1.2037±0.4095μg/ml。说明酒精可增加短柄乌头的毒性。 相似文献
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本研究利用GC/MS(ELPCI)技术,在度冷丁滥用者不中确认了6种代谢产物,并建立了GC/FID分析度冷丁及其代谢产物的方法,方法线性范围0.1~20μg/ml,变异系数小于10%,最小检出量为50ng/ml,适用于度冷丁成瘾者尿中含量的测定。 相似文献
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大鼠闭合性脑损伤后血清髓鞘碱性蛋白研究 总被引:1,自引:0,他引:1
用ELISA双抗体夹心方法研究了大鼠闭合性弥漫性脑损伤后,血清髓鞘碱性蛋白(MBP)含量的时序变化。正常大鼠血清中MBP为6.1633±1.5301ng/ml(X±S)。伤后立即死亡组大鼠的血清MBP为11.3818±2.6574ng/ml,伤后15min,为10.8319±2.3135ng/ml,此血清高MBP水平一直持续到伤后3天。伤后第4天和第5天,血清MBP基本恢复到正常水平。立即死亡组、伤后15min组和伤后3天之内各组的MBP水平与正常组和伤后第4天和第5天的比较,P<0.01。认为可进一步探讨将血清MBP含量的检测,作为脑震荡性脑损伤的辅助生化诊断指标之一 相似文献
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建立高效液相色谱法对人脊髓中利多卡因进行分析的方法,以扩大药(毒 )物检测药围及检测手段,适应法医学鉴定及对特殊检材检验的需要,用利多卡因标准品及空白脊髓标准添加实验,对色谱条件、样品处理方法,回收率及方法的线性和精密度进行了系统考察。所建方法线性范围是2.0~20.0μg/ml(r=0.9999),最低检测限为0.2μg/ml(S/N≥),加样回收率为82.4%~92.7%,该法选择性好、不受干 相似文献
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SPME-GC\NPD法快速分析尿液中苯丙胺类化合物 总被引:11,自引:1,他引:10
建立了SPME-GC/NPD法同时分析尿液中九种苯丙胺类化合物的方法。取1ml尿样以4-苯基丁胺为内标,在碱性条件下,将100μmPDMS纤维头浸入尿液中20min,气相色谱进样后热解吸3min,用GC/NPD进行测定。九种苯丙胺类化合物及内标完全分离,五种苯丙胺类化合物分别在0.05~15、0.1~15、0.2~15μg/ml浓度范围内线性良好,r为0.9928~0.9995,变异系数均小于10%。方法简便、快速、准确,可用于尿液中苯丙胺类违禁药物的检测 相似文献
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Sthaneshwar Timalsina 《Journal of Indian Philosophy》2009,37(4):367-382
The concept of avidyā is one of the central categories in the Advaita of Śaṇkara and Maṇḍana. Shifting the focus from māyā, interpreted either as illusion or as the divine power, this concept brings ignorance to the forefront in describing duality
and bondage. Although all Advaitins accept avidyā as a category, its scope and nature is interpreted in multiple ways. Key elements in Maṇḍana’s philosophy include the plurality
of avidyā, individual selves as its substrate and the Brahman as its field (viṣaya), and the distinction in avidyā between non-apprehension and misapprehension. A closer investigation shows that Maṇḍana is directly influenced by Bhartṛhari’s
linguistic non-dualism in developing the concept of avidyā. This study also compares other key constituents such as
vivartta and pariṇāma that are relevant to the analysis of avidyā. As the concept of counter-image (pratibimba) emerges as a distinct stream of Advaita subsequent to Maṇḍana, this study also compares the application of pratibimba in the writings of Bhartṛhari and Maṇḍana. 相似文献
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David Mellins 《Journal of Indian Philosophy》2007,35(3):227-251
In his twelfth century alaṃkāraśāstra, the Candrāloka, Jayadeva Pīyūṣavarṣa reverses the sequence of topics found in Mammaṭa’s Kāvyapr-akāśa, an earlier and immensely popular work. With such a structural revisionism, Jayadeva asserts the autonomy of his own work
and puts forth an ambitious critique of earlier approaches to literary analysis. Jayadeva investigates the technical and aesthetic
components of poetry in the first part of the Candrāloka, prior to his formal semantic investigations in the latter half of the text, thus suggesting that aesthetic evaluations of
poetry beneficially inform scientific investigations of language. Jayadeva’s organization of his chapters on the semantic
operations, moreover, intimates that the study of suggestive and metaphoric functions of language clarifies our understanding
of denotation, which is conventionally understood to be the primary and direct path of verbal designation. 相似文献
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Douglas Osto 《Journal of Indian Philosophy》2009,37(3):273-290
This article argues for a new interpretation of the Sanskrit compound gaṇḍa-vyūha as it is used in the common title of the Mahāyāna text the Gaṇḍavyūha-Sūtra.The author begins by providing a brief history of the sūtra’s appellations in Chinese and Tibetan sources. Next, the meanings
of gaṇḍa (the problematic member of the compound) are explored. The author proposes that contemporary scholars have overlooked
a meaning of gaṇḍa occurring in some compounds, wherein gaṇḍa can mean simply “great,” “big” or “massive.” This general sense is particularly common in the compound gaṇda-śaila (a “massive rock” or “boulder”) and is found in such texts as the Bhāgavata Purāṇa, the Harivaṃśa and the Harṣacarita. Following the discussion of Gaṇḍa, the author examines the term vyūha (“array”) as it is used in the Gaṇḍavyūha-sūtra. The article concludes with the suggestion that a more appropriate translation of the Gaṇḍavyūha-sūtra would be “The Supreme array Scripture.” 相似文献
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Luminol, leuchomalachite green, phenolphthalein, Hemastix, Hemident, and Bluestar are all used as presumptive tests for blood. In this study, the tests were subjected to dilute blood (from 1:10,000 to 1:10,000,000), many common household substance, and chemicals. Samples were tested for DNA to determine whether the presumptive tests damaged or destroyed DNA. The DNA loci tested were D2S1338 and D19S433. Leuchomalachite green had a sensitivity of 1:10,000, while the remaining tests were able to detect blood to a dilution of 1:100,000. Substances tested include saliva, semen, potato, tomato, tomato sauce, tomato sauce with meat, red onion, red kidney bean, horseradish, 0.1 M ascorbic acid, 5% bleach, 10% cupric sulfate, 10% ferric sulfate, and 10% nickel chloride. Of all the substances tested, not one of the household items reacted with every test; however, the chemicals did. DNA was recovered and amplified from luminol, phenolphthalein, Hemastix, and Bluestar, but not from leuchomalachite green or Hemident. 相似文献
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In the study of Buddhism it is commonly accepted that a monk or nun who commits a pārājika offence is permanently and irrevocably expelled from the Buddhist monastic order. This view is based primarily on readings
of the Pāli Vinaya. With the exception of the Pāli Vinaya, however, all other extant Buddhist monastic law codes (Dharmaguptaka, Mahāsāṅghika, Mahīśāsaka, Sarvāstivāda and Mūlasarvāstivāda)
contain detailed provisions for monks and nuns who commit pārājikas but nevertheless wish to remain within the saṅgha. These monastics are not expelled. Rather, they are granted a special status known as the śikṣādattaka. In this paper I explore the rules. concerning pārājika penance and the śikṣādattaka with specific regard to monastic celibacy. Given that five out of six extant law codes recognise this remarkable accommodation
to the rule of celibacy, I argue that we must look to Vinayas other than the Pāli Vinaya if we are to arrive at a nuanced and representative view of Indian Buddhist monasticism.
Grant me chastity and continence, but not yet. Augustine of Hippo (354–430 C.E.)相似文献
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Alysa Levene 《The History of the Family》2013,18(2):67-79
This article traces new cycles of interest in past children as distinct from past childhood. Recent work highlighting that a conceptualisation of childhood existed even in periods with few written records closes the chapter begun by Philippe Ariès in 1960. Instead, there has been a new surge of interest in children on the edges of family life, as well as children in similarly liminal positions between the worlds of adults and children: runaways, delinquents and orphans. Several themes in the literature are identified, based on the conflicting ideas of ‘body/mind’, ‘victim/threat’, ‘needs/rights’. It is noted that researchers are using more imaginative ways of reaching the lived experience of children than the family or institutional framework, and that an increasing link is drawn between historical and modern concerns such as child abuse and the care of ‘at risk’ children. 相似文献
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《Science & justice》2022,62(6):785-794
This paper considers whether the adoption of a subject-specific, classroom-based, voluntary extra-curricular student mentoring scheme could provide an effective mechanism and andragogic approach to enhance higher education students’ employability potential pre-graduation.Over the three-year pilot, 26 more advanced (second to fourth year) undergraduate students actively mentored nearly 400 first year undergraduate students during workshops delivered annually within forensic and policing focused courses. In total, 17 mentors anonymously completed online, post-scheme surveys. Survey data was quantitatively analysed to evaluate the scheme, establish which skills and attributes mentors had developed and investigate whether mentors could appropriately identify example skills within professional terminology used during employer recruitment. In addition, this paper reflects on the implementation of remote student mentoring during the COVID-19 pandemic and its adoption within a blended learning framework.The results from this research strongly support mentoring as an effective mechanism to develop undergraduate employability skills, significantly developing mentors’ self-confidence and self-efficacy in their interpersonal and communication skills. Although mentors were aware of university graduate attributes and thought they could evidence these with appropriate examples, in practice this was not necessarily the case. As a result, a framework is proposed to enable mentors to identify their skills and how they may align with competencies sought by relevant forensic and policing employers. However, other andragogic practices may need to be implemented to maximise the potential for successful graduate employment. 相似文献
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Valerie Stoker 《Journal of Indian Philosophy》2007,35(2):169-199
This article explores the way in which Madhva (1238–1317), the founder of the Dvaita Vedānta system of Hindu thought, reformulates
the traditional exegetic practice of nirukta or “word derivation” to validate his pluralistic, hierarchical, and Vaiṣṇava reading of the Ṛgvedic hymns. Madhva’s Ṛgbhāṣya
(RB) is conspicuous for its heavy reliance on and unique deployment of this exegetical tactic to validate several key features
of his distinctive theology. These features include his belief in Viṣṇu’s unique possession of all perfect attributes (guṇaparipūrṇatva)
and His related conveyability by all Vedic words (sarvaśabdavācyatva). Such an understanding of Vedic language invokes the
basic nirukta presupposition that words are eternally affiliated with the meanings they convey. But it is also based onMadhva’s
access to a lexicon entitled Vyāsa’s Nirukti with which his critics and perhaps even his commentators seem to be unfamiliar.While
the precise status of this text is the subject of ongoing debate, Madhva’s possession of special insight into the sacred canon
is established in part by his unique claim to be an avatāra of the wind god Vāyu and a direct disciple of Viṣṇu Himself in
the form of Vyāsa1. Thus, Madhva’s use of nirukta invokes his personal charisma to challenge not only conventional understandings of the hymns
but traditional exegetic norms. Madhva’s provision of an alternative tradition of nirukta provoked sectarian debate throughout
the Vijayanagara period over the extent to which one could innovate in established practices of reading the Veda. Articulating
the Veda’s precise authority was a key feature of Brahmin debates during this period and reflects both the empire’s concern
with promoting a shared religious ideology and the competition among rival Brahman sects for imperial patronage that this
concern elicited. By looking at how two of Madhva’s most important commentators (the 14th-century Jayatīrtha and the 17th-century Rāghavendra) sought to defend his niruktis, this article will explore how notions of normative nirukta were articulated
in response to Madhva’s deviations. At the same time, however, examining Madhva’s commentators’ defense of his niruktis also
demonstrates the extent to which Madhva actually adhered to selected exegetic norms. This reveals that discomfort with Madhva’s
particular methods for deriving words stemmed, in part, from a more general ambivalence towards this exegetical tactic whose
inherent open-endedness threatened to undermine the fixity of the canon’s very substance: its language.
Vyāsa’s Nirukti is one of several ”unknown sources” cited in Madhva’s commentaries whose exact status continues to be debated.
Some scholars (e.g. Rao, Sharma, Siauve) maintain that these texts are part of a now lost Pāṅcarātra tradition that Madhva
is attempting to preserve. This may be true for many of these citations. However, in addition to claiming to be both an avatāra
of Vāyu and Viṣṇu-as-Vyāsa’s student, Madhva states in several places (e.g., VTN 42, RB 162) that the canon has suffered loss
during transmission and that only Viṣṇu can reveal it in its entirety. Thus, it is possible that Madhva intends texts like
Vyāsa’s Nirukti to be viewed as part of an ongoing and corrective revelation, a notion that is compatible with many Vaiṣṇava
traditions (Halbfass, 1991: 4). 相似文献
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Derek Dalton 《Law and Critique》2007,18(3):375-405
Drawing on interview data of gay men who have had their behavior in public spaces scrutinised by agents of the law for signs
deviance, this article explores the historical characteristics of police animosity towards such conduct in Australia. This
entails examining encounters between police and gay men who pursue desire in ‘beat’ (or ‘cottage’ to the use the UK term) spaces. Exploring why these outlaw gay male subjects are so abject and troubling to the law, the
discussion documents how law’s desire to regulate gay men plays out in the masquerade of ‘plain-clothes’ agent
provocateur operations where police entrap gay men by mimicking gay bodily appearances, gestures and mannerisms. This article also examines
how police regulation of gay desire functions as a form of violence that delimits expressions of same sex desire in public
spaces. A key theme that underpins the analyses in this paper is that the policing of desire in ‘beat’ spaces helps produce qualities of illicitness and dangerousness and that this, in turn, fuels the circuit of desire at play
between gay men and agents of the law.
相似文献
Derek DaltonEmail: |