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损伤时间推断是法医学实践中的重要内容,准确推断损伤时间是国内外法医学者亟待解决的科学问题。代谢组学技术可以有效检测机体受到体内外刺激因素作用产生的内源性代谢物,描述生物体内代谢物的动态变化,具有操作性强、检测效率高、定量结果 准确等优势。机器学习算法对高维数据集的处理具有独特优势,能够有效挖掘生物信息,真实反映机体生理、疾病或损伤状态,是高效处理高通量大数据的新型技术手段。本文综述了代谢组学技术与机器学习算法的研究现状和自身优势,探讨应用代谢组学技术结合机器学习算法在法医学损伤时间推断研究中的应用前景,为法医学损伤时间推断研究提供新思路。 相似文献
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《中国法医学杂志》2019,(6)
目的分析首届全国法医学本科技能竞赛试题质量和选手对知识的掌握程度,探讨我国法医学专业本科生病理阅片能力现状、存在问题及对策。方法搜集试题及选手成绩,计算试题信度、难度、区分度;将考生按性别和年级进行分组,对各组学生的三部分(组织病理学基本病变、常见猝死疾病病变、法医病理学专业知识)成绩以及总成绩进行比较。结果试卷信度系数为0.991,信度优秀。区分度为0.30~0.98,整体很好。各题难度在0.29~0.89,试卷总体难度为0.66,难度适中。不同性别、年级的考生成绩组间无统计学差异(P0.05)。结论首届全国法医学本科技能竞赛试题安排合理,难度适中,区分度好;法医学本科生法医病理组织切片的阅片能力一般,小部分较差,法医专业本科生法医病理学阅片能力尚待提升。 相似文献
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目的采用代谢组学技术研究深静脉血栓形成(deep venous thrombosis,DVT)大鼠尿液中代谢物谱,筛选出可用于DVT诊断和法医学鉴定的小分子生物标志物。方法建立下腔静脉完全结扎DVT大鼠模型,分为模型组、假手术组和对照组,每组各10只。模型组和假手术组大鼠在建模后48 h于代谢笼中收集24 h尿液,同时对照组收集24 h尿液。核磁共振检测其代谢物谱,SIMCA-P 14.1软件进行模式识别,通过正交偏最小二乘法-判别分析(orthogonal PLS-DA,OPLS-DA)模型中的变量权重重要性排序(variable importance in projection,VIP)值结合Mann-Whitney U检验,寻找尿液中差异代谢物。结果模型组、假手术组和对照组大鼠尿液的代谢轮廓呈现显著性差异。通过偏最小二乘法-判别分析(partial least squares method-discriminant analysis,PLS-DA)模型可以有效判别模型组、假手术组与对照组。与对照组大鼠相比,DVT大鼠尿液中亮氨酸、谷氨酰胺、肌酸、肌酐和蔗糖水平上调,3-羟基丁酸、乳酸、丙酮、α-酮戊二酸、柠檬酸和马尿酸水平下调。结论 DVT大鼠尿液中的差异代谢物有望成为该疾病的候选生物标志物,该结果可为DVT的诊断、治疗和法医学鉴定提供研究基础。 相似文献
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This study assessed whether obesity significantly affects femoral shape. Femora of 121 white men were divided into two weight classes based on body mass index (BMI) of the deceased. Five external anteroposterior (AP) and mediolateral (ML) measurements were taken at consistent percentages of diaphyseal length. These were then subject to statistical tests. After controlling for age, multivariate statistics show a significant (p<0.05) effect of BMI on the femur, with the greatest significance in ML measurements. T-tests confirm these dimensions are significantly larger in the overweight (p<0.05). The effect of BMI on size-transformed and shape-transformed variables was also evaluated, with ANOVA results showing a significant BMI effect on ML size (p<0.05), but not shape. Significant size-transformed ML variables were then subject to discriminate function analyses with a cross-validation correction. Results show a correct classification rate of 88% in normal weight and 77% in overweight individuals. 相似文献
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以南京市城乡若干社区的实证调查为研究个案,深入探讨居民对街道办(乡镇)政府的信任度对居民参与社区志愿服务的意愿与居民的社区志愿精神究竟有何种程度的影响。通过Logistic回归分析,研究结果发现居民对街道办(乡镇)政府的信任度与居民的社区志愿精神之间存在着密切的关联性。对于各级政府而言,本研究的政策含义是需要特别关注影响居民对街道办(乡镇)政府信任的各种居民背景因素,培育居民对街道办(乡镇)政府的信任感和亲切感,不断促进居民社区志愿精神的孕育与成长,从而凝聚成社区草根民主成长的动力和纽带。 相似文献
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Natasha Stojanovska Ph.D. Adrian De Grazia Hons. Mark Tahtouh Ph.D. Ronald Shimmon Ph.D. Brian Reedy Ph.D. 《Journal of forensic sciences》2015,60(3):619-626
In further work investigating the intriguing application of diacetylene copolymers in fingermark detection, methods were developed to control (inhibit or enhance) the diacetylene polymerization reaction in fingermarks treated with a mixture of the monomers 2,4‐hexadiyne‐1,6‐bis‐(phenylurethane) (HDDPU) and 2,4‐hexadiyne‐1,6‐bis(p‐chlorophenylurethane) (HDDCPU) in acetone solution. These methods included the use of a humidity chamber to reduce the amount of background development while promoting development on the fingermark, subjecting developed fingermarks to freezing temperatures and using a solvent to remove unreacted monomer in order to inhibit the polymerization reaction. Developed fingermarks were enhanced by conventional lighting (white light, filtered light) and fast Raman mapping, which was shown to be advantageous over FTIR imaging. This study also demonstrated the applicability of diacetylene copolymer solutions in the covert detection of fingermarks on difficult surfaces. Furthermore, fingermarks were successfully developed with good ridge detail on pig skin (used as a model for human skin, a notoriously difficult surface on which to develop fingermarks). 相似文献
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This study utilized a justice framework to investigate punished subordinates' attitudinal reactions to specific disciplinary events. Results suggested that personality variables (negative affectivity and belief in a just world) influenced subordinate perceptions of the disciplinary event. In addition, belief in a just world had a direct effect on satisfaction with the supervisor, intention to leave, and organizational commitment. Contrary to expectations, harshness (a distributive aspect of the event) influenced perceptions of procedural justice and attitudes toward the institution (organizational commitment) and the leader (trust in supervisor), in addition to its influence on perceptions of distributive justice. The influence of procedural aspects of the event on attitudinal outcomes varied by dependent variable. The implications for future research and for management are discussed. 相似文献
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Grant D. De Jong M.S. W. Wyatt Hoback Ph.D. Leon G. Higley Ph.D. 《Journal of forensic sciences》2011,56(1):143-149
Abstract: Often carrion decomposition studies are conducted using a single carcass or a few carcasses sampled repeatedly through time to reveal trends in succession community composition. Measurements of biomass and other abiotic parameters (e.g., temperature) are often collected on the same carcasses but are rarely a focal point of the studies. This study investigated the effects that repeated sampling during experiments have on the decomposition of carrion, measured as both gross biomass (carcass plus fauna) and net biomass (carcass only), on carcasses disturbed on every visit (with weighing only or also with the collection of fauna) and on carcasses disturbed only once. Each trial lasted at least 21 days, with samples taken in triplicate. Rat carcasses used in this study were placed in the field on the same day and either weighed on every visit or ignored until a given day. Internal and ambient air temperatures were recorded on each carcass at the time of sampling and on undisturbed carcasses using temperature loggers. The presence of succession fauna did not result in significant biomass loss on most days; however, there were individual days early in decomposition (days 3 through 6) when the succession fauna comprised a large portion of the gross biomass. With the exception of biomass loss by the emigration of maggots on days 4 and 5, neither repeated weighing of the carcasses nor repeated weighing and faunal sampling of the carcasses statistically affected the rate of biomass loss. Internal temperatures of carcasses sampled repeatedly were frequently 2–5°C lower than those that had not been disturbed, and ambient temperatures differed significantly depending on the location of measurement device. Results indicate that methods used historically for biomass loss determination in experimental forensic entomology studies are adequate, but further refinements to experimental methodology are desirable. 相似文献
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We present a review of theoretical and methodological advances in the social scientific literature on environmental inequality/racism and argue for new directions in research efforts that pay more attention to (1) the historical forces driving environmental justice conflicts; (2) the complex role of stakeholders in these struggles; (3) the role of social inequality, particularly the trade-offs between environmental protection and social equity; and (4) the impact of social movement activity on the state of environmental protection. Drawing on a case study of an environmental justice conflict in the United States, we find that environmental inequality impacts many actors with often contradictory and cross-cutting allegiances. These struggles therefore become a moving drama—a process—rather than a cross-sectional outcome. We conclude with an analysis of environmental inequality on a global scale and argue that the role of transnational capital remains largely untheorized in the literature. We suggest new models for explaining environmental inequality's causes and consequences. 相似文献
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Thali MJ Kneubuehl BP Bolliger SA Christe A Koenigsdorfer U Ozdoba C Spielvogel E Dirnhofer R 《Forensic science international》2007,172(1):63-66
The most popular handgun in Brazil is the single round-barrel caliber 0.38 revolver. In recent years, however, owing to the modernization of police arms and their availability on the legal and illicit markets, pistols have become increasingly popular and currently represent about 20% of police seizures. In a previous paper we presented a novel collection method for gunshot residues (GSR) using a sampling procedure based on ethylenediamine-tetraacetic acid (EDTA) solution as a complexing agent on moistened swabs with subsequent detection using sector field-high resolution-inductively coupled plasma-mass spectrometry (SF-HR-ICP-MS). In the present paper, we discuss the capability of this methodology to identify antimony (Sb), barium (Ba) and lead (Pb) on the hands of volunteers after shot tests with 9 mm and 0.40 in. caliber pistols. Two types of munitions were tested: 9 mm Taurus and clean range. The use of a technique with high sensitivity, such as SF-HR-ICP-MS, permits the identification of low concentrations (less than 1 microg/L) of metals in firearm residue and constitutes a powerful tool in forensic science. We also discuss the importance of the sampling procedure, including collection from a different body part than the gun hand of the suspect. Comparison of the analytical data obtained allows clear discrimination between samples from the hands of shooters and non-shooters. 相似文献
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D.R. Schillaci 《Forensic Science International Supplement Series》2009,1(1):24-26
In Italy in 2007, 26% of two-wheeled motor vehicle injury/fatalities concerned motorcyclists. However, it is rare (4%) that a motorcycle (MC) crashes with two other road users and even more exceptional is a crash between a MC and three other vehicles. In general, in MC–vehicle crashes, the vehicle driver is at fault in more than 50% of the cases and the motorcyclist in 37%. The study concerns three MC lethal road accidents in which the culpability of the motorcyclist's death was questioned by the prosecutor because it was supposed that one or more vehicles ran over the motorcyclist after a fall. The crucial question in these three cases was if it was possible to assign injuries to a specific crash-aetiology and to assign/exclude the responsibility of motorcyclist's death to a defined subject (motorcyclist himself and/or car drivers) after a crash-dynamics study made by an engineer consultant or by the police authority. Case (1) A 56-year-old motorcyclist on a highway had a front–rear end collision with a car that suddenly stopped; he was therefore projected against a concrete traffic island, thrown on the soil and run over by another car. Case (2) A 29-year-old motorcyclist on the East ring road fell on the soil, perhaps by a supposed front–rear end contact with a car and was run over by two cars in rapid succession. Case (3) A 34-year-old motorcyclist on the North ring road fell suddenly on the soil for unknown reasons; during first aid, the medical team around him was run over by the ambulance which pushed after a rear-end collision with a car. A stepwise analysis of the indicated crash dynamics and an evaluation of all the injuries revealed at autopsy, the study proposed, when possible, injury aetiology for each case and the related responsibility assignments and exclusions. 相似文献
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XU Haiyan 《Frontiers of Law in China》2020,15(2):142
A major concern on base erosion and profit shifting (BEPS) is transfer pricing, which is discussed in BEPS Action Items 8–10 and 13. Actions 8–10 contain revised guidance, which ensures that transfer pricing rules secure outcomes that better align operational profits with the economic activities that generate them, as well as guidance on transactions involving cross-border commodity transactions and on low value-adding intra-group services. Action 13 contains a three-tiered standardized approach to transfer pricing documentation, including a minimum standard on country-by-country reports (CbCRs). However, the approach of Actions 8–10 still focuses on the restoration of the dysfunctional rules built on the arm’s length principle, which is rooted in the principle of separate independent entity. The threshold of Action 13 excludes many large multinational enterprises (MNEs) from the CbCR requirement and deprives developing countries access to the information of MNEs below the threshold. Chapter 6 of the Chinese Corporate Income Tax Law, under the title “Special Tax Adjustments,” provided the legal foundations of transfer pricing and transfer pricing documentation in China. To effectively implement the BEPS package in China and to comprehensively update the existing Circular 2, the State Taxation Administration (STA) released a Discussion Draft of a Circular on Implementation Measures for Special Tax Adjustments in September 2015, ranging from Action 3 (controlled foreign company rules), Action 8–10 (aligning transfer pricing outcomes with value creation) to Action 13 (transfer pricing documentation and country-by-country reporting) in details. Right now, a series of patches, such as the STA Bulletins 45, 42, 64, and 6, have been made to replace a substantial part of Circular 2. 相似文献
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The paper investigates the French dilemma associated with court administered resolution of corporate financial distress. In such a legal system, the courts seek a double objective: maintaining job positions through continuation, and determining the best outcome for the claimants. We discuss this dilemma empirically, using a unique sample of bankruptcy files on French SMEs. We address successively three critical questions. First, we highlight the determinants of the final bankruptcy outcome (continuation through reorganization or sale, or piecemeal liquidation): does continuation (the most employment-friendly outcome) depend on the firm's characteristics, and/or on the way the procedure is managed? Second, we study the determinants of the creditors’ recovery rates: do the courts play an active role in increasing recoveries? Third, we address the dilemma directly by focusing on sales as a going concern. We model the court administered selection process between rival buyout offers: do the courts balance the social content against the financial content of each offer? Is there an explicit arbitrage between employment preservation and creditor recoveries? Our main results are: (1) the French courts actively work to facilitate continuation against liquidation, and thus play a role in employment preservation. Besides, we find continuation is more likely to prevail when default is an outcome of specific difficulties (outlets, finance, and production). (2) We confirm the Radulovic (2008) findings: the global recovery rate mainly depends on the firm's ex ante characteristics at the time of triggering, while the way the procedure is managed by the court has little impact. Similarly to LoPucki and Doherty (2007), continuation via reorganization does not generate lower recovery rates on average than the other outcomes. (3) Last, the courts’ choice between rival buyout offers confirms that social considerations prevail in the arbitration. Yet, the courts still consider financial issues as well (a higher sale price increases the chances that an offer is selected), but without clear connection with the amount of due claims (one direct consequence is a moderate recovery rate on sales). 相似文献