生物超弱发光在法医学中的研究应用展望

生物超弱发光携带着生物体新陈代谢和能量转化的信息,已成为生命学科的重要研究领域。本文回顾生物超弱发光的研究历史、特点及在医学领域的研究应用现状,展望生物超弱发光在法医学,尤其是死亡时间推测和损伤方面的研究应用前景     

Effective use of forensic science in volume crime investigations: Identifying recurring themes in the literature

New scientific, technological and legal developments, particularly the introduction of national databases for DNA and fingerprints, have led to increased use of forensic science in the investigation of crime. There is an assumption, and in some instances specific assertions, that such developments bring improvements either in broad criminal justice terms or more narrowly in terms of economic or practical efficiencies. The underlying presumption is that the new technological opportunities will be understood and effectively implemented. This research investigates whether such increases in activity have also been accompanied by improvements in the effective use of forensic science. A systematic review of thirty-six reports published (predominantly in England and Wales) since the 1980s, which have considered the use of forensic science in the investigation of volume crimes, was carried out. These reports have identified a number of recurrent themes that influenced how effectively forensic science was used in investigations. The themes identified included forensic knowledge and training of investigators, communication and information exchange between specialists and investigators, timeliness of forensic results, interagency relationships and deployment of crime scene examiner resources. The research findings suggest that these factors continue to hinder the effective use of forensic science despite technological advances and this paper considers their potential causes.     

Please Don't Use Science or Mathematics in Arguing for Human Rights or Natural Law

In the vast literature on human rights and natural law one finds arguments that draw on science or mathematics to support claims to universality and objectivity. Here are two such arguments: 1) Human rights are as universal (i.e., valid independently of their specific historical and cultural Western origin) as the laws and theories of science; and 2) principles of natural law have the same objective (metahistorical) validity as mathematical principles. In what follows I will examine these arguments in some detail and argue that both are misplaced. A section of the paper will be devoted to a discussion of arguments relying on the historical and cultural specificity (and intrinsic superiority) of Western science. The conclusion is that both science and mathematics offer little help to anyone wanting to make use of them as paradigms of universality, objectivity, and rationality. Finally, I will draw some consequences for the idea of human rights.     

Rapid genomic DNA extraction (RGDE)

Hyperpolymorphic short tandem repetitive DNA sequences, STRs or microsatellites, have become widely used in human identification, particularly in criminal cases and in mass disasters. In such cases the substrates for the analyses may be decomposed as a biological material, a fact that has to be taken into account when choosing the appropriate casework methods. Nowadays expanded windows have been opened to the world especially in the area of genetic and biology science by performance of big projects such as human genome project. In this regard, one of the primary and important steps for all is DNA extraction with high quality and quantity in minimum time from biological material. By using RGDE method, genomic DNA with high quality and quantity can be acquired in the shortest time which has been presented in the world up to now. In this paper we report the evaluation of DNA extraction in this method.     

Law and the New Potentials of Biology

The biological stage of the revolution in science and technology represents a continuing and accelerating "switching" of science to a focus on man as studies advance from the lower to higher levels of organization of animate systems. With the help of science, the nature of man will adapt itself more and more to new environmental conditions as they change under the influence of scientific and technical progress. Attainment of this objective involves further development of human genetics and genetic engineering. Its next stage, with respect to man, will be "correction" of the functioning of pathological genes, and later will come replacement of them by normal ones, thereby opening a new road to prevention of hereditary disease. The first achievements along these lines have already been attained in the form of successes in the synthesizing of genes and development of methods of introducing them into the genetic apparatus. A number of forms of genetic management pose important ethical and legal problems: the use of transplants from cell nuclei to obtain numerous copies of identical organisms (vegetative multiplication); the possibility of artificial fertilization of the human egg followed by reimplantation into the womb; prenatal diagnosis of possible genetic disease by biochemical or cytogenetic analysis of the amniotic fluid. Such analysis is already in use. Artificial fertilization is also possible now, although genetic management in this connection will become a reality only some years hence. Vegetative multiplication is not yet possible with respect to human beings, although that possibility cannot be ignored.     

Outstanding ethical-legal issues on biobanks. An overview on the regulations of the Member States of the Eurobiobank project.

EuroBiobank (EBB) was created in 2001. This is a network of European biological banks made up by 7 member States. The purpose of the network is to ease the access to the biological resources of the human being in patients who suffer uncommon diseases. This study deals mainly with the ethical-legal debate that has arisen in those States, as well as the existing legal regulation and the proposed recommendations for its possible solution. Likewise, there is a special mention about the informed consent, the possible use in the future of the samples in relation to its commercial use as industrial property rights and to Directive 2004/03 that was adopted by the European Parliament 31 March, 2004.     

运用分子生物学方法鉴定生物检材种属的研究进展

生物检材的种属鉴定在法医、海关和食品行业中均有较多应用。当前,用于鉴定种属的分子生物学方法发展迅猛。本文结合文献,从用于种属鉴定的目的基因及筛选标准、主要分子生物学方法、鉴定存在的主要问题等方面进行综述,并结合Real-time PCR和SNP技术对未来种属鉴定的发展方向进行了预测。     

B. F. Skinner's utopian vision: behind and beyond walden two

This paper addresses B. F. Skinner's utopian vision for enhancing social justice and human well‐being as it was introduced in his 1948 novel, Walden Two. In the first part, we address the historical, intellectual, and social context that situates the book in the utopian genre, the critiques of its premises and practices, and the fate of intentional communities patterned on the book. In the second part, we review practices in Skinner's book that advance social justice and human well‐being under the themes of health, wealth, and wisdom, and then focus on contemporary practices that are the legacy of his vision. His vision was neither the a priori truth of a particular premise about human behavior or a necessary practice (blueprint) for an intentional community but rather the use of empirical methods to discover premises and practices that work to advance the health, wealth, and wisdom of individuals and survival of the culture.     

Property Rights and Biodiversity

This essay deals with the allocation of genetic resources with regard to property-rights theory. In addition to this, different arrangements of property rights will be examined as to their allocation and distribution effects. The result will show that property rights on biological diversity can only cover patrimonial rights which contain the right to use the resource but not to destroy it. Bioprospecting conventions, such as the well known Merck-INBio agreement, will be examined as mechanisms to establish property rights in terms of biological diversity. Moreover, the identification of these agreements will be critically questioned for their applicability as a form of the Coase-theorem.     

Strategic Research Partnerships: Constructing Policy-Relevant Indicators

Absent a set of indicators based on a set of valid constructs, it will remain difficult to determine the importance of strategic research partnerships (SRP) for the U.S. economy and the enterprise of science and technology in general. The purpose of this paper is to identify characteristics of a desirable policy indicator for strategic research partnerships. In choosing among the many possible conceptualizations and indicators of SRP, a framing question should be: “what is the public stake?” The fact that SRP activity has great economic import (still an open question) does not imply an equivalent government or public policy importance. This seems to imply, then, that SRP indicators should focus on such factors as the composition of R&;D (e.g. do they shift the balance in available public domain research?), impacts of labor and human resources, tax implications (e.g. use of tax credits, foregone revenue and its impacts), and, especially, public-private partnerships (e.g. how are government-sponsored or -brokered SRPs different from others?).     

On creating ethical,productive, and durable research partnerships with police officers and their departments: a case study of the National Justice Database

ABSTRACT

Translational policing science must begin with explicitly communicated research aims and a shared vision for promoting safety. For researchers to approach police departments without first considering the concerns held by officers and their departments at large, is unethical, unproductive, and undermines efforts to secure longstanding mutually useful researcher-practitioner partnerships. In presenting a case study analysis of the multi-method National Justice Database’s recruitment practices, this article highlights some of the challenges that emerge when articulating study aims that hold relevance for public safety; defining theoretically- and solution-oriented research questions; administrative police data collection, analysis, and dissemination; and bolstering human research subject protection protocols for sworn officers who may be justifiably reluctant to participate in social science research endeavors. Implications for ethical policing research practice, fostering collaborative researcher-practitioner partnerships, and leveraging the benefits of data science are also discussed.     

Context effects in forensic science: a review and application of the science of science to crime laboratory practice in the United States.

This article discusses the phenomenon of "context effects" by reviewing the findings and practices of a range of scientific fields, including astronomy, physics, biology, medicine, and especially the relevant research and theory from psychology. Context information, such as expectations about what one is supposed to see or conclude, has been found to have a small but relentless impact on human perception, judgment, and decision-making. The article then considers the vulnerability of forensic science practice to context effects, and concludes by suggesting that forensic science adopt practices familiar in other fields of scientific work, in particular blind or double-blind testing and also the use of evidence line-ups.     

Canada's Assisted Human Reproductive Act: is it scientific censorship, or a reasoned approach to the regulation of rapidly emerging reproductive technologies?

After more than a decade of study, discussion and debate, the Canadian House of Commons and Senate have approved the Assisted Human Reproduction Act. Building on the earlier Bill C-47, which died on the order paper in 1997, the Act bans human cloning for reproductive or therapeutic purposes, payment for surrogacy arrangements, and trading in human reproductive materials or their use without informed consent. In addition, the Act significantly restricts research using human reproductive materials. This article compares the Act to legislative regimes in other nations with advanced human reproductive science. It concludes that while the Act has many laudable goals, it is flawed in that it tries to cover too much legislative ground. As a result it unreasonable impairs the ability of Canadian scientists to compete in areas such as stem cell research, and area that is expected to yield significant new approaches to treating human disease.     

当代知识产权制度的新发展及其对我国的启示

随着科学技术的发展、知识经济的兴起和经济全球化进程的加快,知识产权的重要性得到历史性提升。在科技高速发展的今天,知识产权保护制度呈现许多新特点。面对新形势,我们应该以全球的视野,站在国家利益的高度来认识知识产权,主动、积极地运用知识产权保护制度参与国际市场竞争。     

我国农业人才资源开发的调查与思考

随着改革开放不断地深入、发展,我国农业及农村经济增长逐步转移到依靠农村科技进步和提高劳动者素质的轨道上来。本文试图通过近几年来,党和国家政府对农村各项政策的落实这个角度,从未来农村经济发展离不开农业技术、农村科技人才这个基本点出发,对如何提高、引进农村实用型人才,进行探讨、研究,以便能更好地为社会主义新农村建设,探索出一条有益的途径。     

Network and perceptual determinants of satisfaction among science and engineering faculty in US research universities

This study examines how personal research collaboration and advice networks of academic faculty in six fields of science and engineering affect three kinds of satisfaction: satisfaction with rewards; satisfaction with reputation of department and institution; and satisfaction with professional recognition and visibility of research. The study includes determinants found in the literature such as perceived influence on departmental decisions, departmental provision of resources, and perceptions of time spent on service and other controls. Using data collected from a national survey of academic faculty in six fields of science and engineering in Carnegie designated Research I universities, regression models test literature derived hypotheses. Findings show that the effects of network structure and resources on satisfaction depend on the kind of satisfaction studied. Non-network variables demonstrate associations with satisfaction that are generally expected from the literature. The paper provides evidence of the critical role that personal research collaboration and advice networks play for scientists’ satisfaction. It also raises important questions about the complex relationships between network structures and resources, and satisfaction. Conclusions present implications for university and departmental administrators.     

Inactivation of human immunodeficiency virus (HIV) by ionizing radiation in body fluids and serological evidence

A method to use ionizing radiation to inactivate HIV (Human Immunodeficiency Virus) in human body fluids was studied in an effort to reduce the risk of accidental infection to forensic science laboratory workers. Experiments conducted indicate that an X-ray absorbed dose of 25 krad was required to completely inactivate HIV. This does not alter forensically important constituents such as enzymes and proteins in body fluids. This method of inactivation of HIV cannot be used on body fluids which will be subjected to deoxyribonucleic acid (DNA) typing.     

A comprehensive study into false positive rates for ‘other’ biological samples using common presumptive testing methods

The identification of biological fluids or materials in forensic samples is a key requirement in forensic science that relies on chemical and biological based tests, most of which exhibit false positivity. When reporting results from such tests, Forensic Scientists use words such as probable, possible, and likely, without always being able to provide robust support for these conclusions. In collating information about false positive rates for a number of these tests, we found limited research into the cross reactions observed from ‘other’ biological samples in commonly encountered case sample stains. By ‘other’ we mean biological fluids or materials that are not the primary target of the presumptive test being used. Here we carry out a specificity study to fill gaps in the literature for a number of the presumptive chemical, biological and immunochromatographic tests used to presumptively screen for blood, semen and saliva. The tests selected for this study are the widely used tests: Luminol, TMB/Combur³ Test® E, Kastle-Meyer (KM), RSID™ - Blood, ABAcard® HemaTrace®, Acid Phosphatase (AP), ABAcard® p30, RSID™ - Semen, Phadebas® ‘Tube’ Test, Phadebas® ‘Press’ Test, and RSID™ - Saliva tests. Specificity for each of these was tested in known samples, from volunteers, of blood, semen, saliva, urine, sweat, vaginal material, faeces and breast milk, and then false positive rates were determined.     

Thirty Years of Social Science in Supreme Court Criminal Cases*

The Supreme Court early took note of extralegal, “social science” materials in Muller v. Oregon (1908), and a half-century later made specific reference to social science authorities in the famous footnote 11 of Brown v. Board of Education (1954). Since Brown, much has been written about the Supreme Court's use of social science research evidence, but there has been little systematic study of that use. Those writing on the subject commonly focus on areas of law such as jury size, where social science has been used, and have generally assumed that social science information has been utilized in Supreme Court decisions with increasing regularity. Surprisingly little is known, however, about either the justices' baseline use of social science authorities, or many other aspects of their uses of social science information. The focus here is on the citation of social science research evidence in a sample of 240 criminal cases decided during the 30 years between the Supreme Court's 1958 and 1987 Terms. The resulting portrait contributes to a fuller understanding of the justices' use of social science materials, and may ultimately help promote more effective utilization of social science research evidence in Supreme Court decisions.