Isolation and Identification of Three By‐products Found in Methylamphetamine Synthesized by the Emde Route

This article describes the isolation and structural elucidation of three compounds produced during the synthesis of methylamphetamine by the so‐called “Emde” procedure. The “Emde” procedure involves the preparation of the intermediate chloropseudoephedrine or chloroephedrine from ephedrine or pseudoephedrine, respectively. The intermediates are then reduced to methylamphetamine with hydrogen under pressure in the presence of a catalyst. The by‐product compounds were isolated from methylamphetamine by column chromatography and liquid chromatography (LC). Proton nuclear magnetic resonance spectroscopy (¹H NMR), carbon nuclear magnetic resonance spectroscopy (¹³C NMR), and nanospray quadrupole‐time of flight‐mass spectrometry (Q‐TOF‐MS) were used to identify them as two stereoisomers of the compound N, N′‐dimethyl‐3,4‐diphenylhexane‐2,5‐diamine and N‐methyl‐1‐{4‐[2‐(methylamino)propyl]phenyl}‐1‐phenylpropan‐2‐amine.     

Identifying Counterfeit Cigarettes Using Environmental Pollen Analysis: An Improved Procedure*

Traditional pollen preparation techniques provide clear residues for pollen identification; however, such methods are time-consuming, requiring repeated centrifugation, heating, and digestion with high-concentration hazardous chemicals. Tobacco leaves can effectively trap environmental pollen due to hairy surface and terpene-rich exudates. A new tobacco sample processing method was developed by using different extraction chemistry with surfactant. Marlboro Gold cigarettes were employed as model samples for method development. Parameters critical for pollen extraction, which include number of cigarette sticks used, extraction solution, and extraction temperature, were optimized. By using 1% dishwashing detergent to treat three cigarettes at room temperature, the improved method was able to recover sufficient pollen for microscopic analysis in three repeated centrifuge-washing steps and omit hazardous chemicals involved in traditional methods. We focused on the pollen of common ragweed (Ambrosia artemisiifolia), a plant native to North America, as an indicator to differentiate genuine and counterfeit U.S. brand cigarettes. Results from analyzing randomly purchased genuine (authenticated by forensic examination) and known counterfeit Marlboro Gold provided by law enforcement revealed that a significant amount (39%) of Ambrosia were consistently present in all genuine samples, while counterfeit contained none or only trace count. Similar results were found in other counterfeit U.S. brand cigarettes (all seized in the U.S.) involved in this study as well. Lack of Ambrosia in cigarette strongly indicates the product was not originated in the United States.     

War and International Order in Kant's Legal Thought“*

Abstract. Kant's writings on international law and especially his Toward Perpetual Peace have been interpreted both in a “statist” and a “cosmopolitan” manner. In this article it is argued that these interpretations stem from an ambiguity in those writings. In the course of proposing a resolution of this ambiguity, the first question to be examined is the extent to which war forms a part of human history and of human nature. Secondly, Kant's arguments against the realistic position and the conditions for a lasting peace are presented. An interpretation is then offered both of the proposed league of nations and of the situation that exists when such a league is still absent. According to the interpretation offered here, Kant's writings fit partly within the tradition of the “just war.”¹     

Mt. Laurel: A View from the Bridge

Across the Delaware River from the “region” which the New Jersey Supreme court appears to suggest should be the planning base for Mt. Laurel Township's land use decisions lies the Commonwealth of Pennsylvania which has been having some severe land use pangs of its own. Long before even the initiation of the Mt. Laurel litigation, the Pennsylvania Supreme Court had begun to decide “exclusionary zoning” cases. And it has continued, intermittently, ever since its National Land ¹ decision in 1965 to admonish municipalities that they must not commit exclusionary² zoning. Thus, the court held a 4 acre minimum lot size exclusionary and then, five years later, held a 2 acre minimum lot size similarily invalid³.     

Effect of two types of control questions and two question formats on the outcomes of polygraph examinations

Abstract: Two major variations of polygraph “Control Question” testing, the Zone Comparison (ZoC) and the Modified General Question Test (MGQT) were evaluated. Within each, the type of control question, Exclusive or “time bar” (e.g., “Before you were 21, did you ever...”) and Nonexclusive or “no time bar”(e.g., “Did you ever….?”) was manipulated in a mock theft scenario, with 80 male and 40 female subjects randomly assigned to be either innocent or guilty. Polygraphic data collected by experienced field examiners were numerically scored by an evaluator blind to all aspects of the study. Decision accuracy was not related to the type of procedure (ZoC/MGQT) used or the subject’s sex. Accuracy was significantly related to the type of control question [χ²(2) = 11.46, p = 0.003; τc = 0.29]. Nonexclusive control questions produced greater accuracy than Exclusive control questions on both innocent and guilty subjects. These results and subjects’ self‐reports support the general “theory” on which control question (CQ) testing is based. The need for better empirical support of accepted dogma and current field practices is strongly indicated by these findings.     

Lost in the System or Lost in Translation? The Exchanges between Hart and Ross*

According to the received opinion there is a theoretical incompatibility between Herbert Hart's The Concept of Law and Alf Ross's On Law and Justice, and, according to the received opinion, it stems above all from Hart's emphasis on the internal point of view. The present paper argues that this reading is mistaken. The Concept of Law does not go beyond On Law and Justice in so far as both present arguments to the effect that law is based on a shared understanding between participants in a project perceived by every participant to be a project in common. The paper demonstrates that there are substantive parallels between Hart's combination of “acceptance” or “acknowledgement” and a “critical reflective attitude” and Ross's combination of “motivation” or “feeling” and a “coherent whole of meaning and motivation.” The main conclusion is that the views of norms and normativity put forward in The Concept of Law and On Law and Justice are very close in essential respects, and, more specifically, that the two works are at root identical in their representation of the basis of normativity in reality.     

Clarifying the complex chemistry of cobalt(II) thiocyanate-based tests for cocaine using single-crystal X-ray diffraction and spectroscopic techniques

Cobalt(II) thiocyanate-based tests are routinely used to screen cocaine products, with the formation of a blue species interpreted as a positive response. An array of other organic bases has been identified as false positives – including well-documented cocaine product adulterant lidocaine and its salt. False positives prompt continued test development, though improvements are hindered by unresolved product structures and reaction pathways. Toward greater clarity, cobalt(II) thiocyanate reactions with cocaine hydrochloride, along with lidocaine and its salt, were investigated using multiple analytical techniques. Reactions involving cocaine hydrochloride yielded glassy, amorphous blue material while reactions of lidocaine hydrochloride monohydrate produced larger, needle-like crystals whose structure was determined via single-crystal X-ray diffraction to be an ion pair (Hlidocaine⁺)₂([Co(SCN)₄]²⁻)·H₂O. While the blue precipitate isolated from reactions involving cocaine hydrochloride was unsuitable for crystallographic structure determination, comparative ultraviolet–visible, attenuated total reflectance infrared, and Raman spectroscopic analysis – along with elemental analysis – supports that this solid is comprised of a comparable ion pair (Hcocaine⁺)₂[Co(SCN)₄]²⁻. Pink crystals isolated from lidocaine reaction vessels were identified as coordination compounds cis-[CoL₂(SCN)₂] and trans-[CoL₂(SCN)₂] where L = lidocaine, while pink crystals from both cocaine hydrochloride and lidocaine hydrochloride monohydrate reaction vessels were the coordination polymer trans-[Co(H₂O)₂(SCN)₂]·H₂O. The results presented herein enable reaction optimization to favor a desired product, whether ion pair or coordination species.     

‘C’ is for commercial collaboration: enterprise and structure in the ‘middle market’ of counterfeit alcohol distribution

This article utilising the work of Pearson and Hobbs [1] defines the middle market in counterfeit alcohol. Drugs markets have a resemblance to counterfeit alcohol markets in as much that they share the illicit nature of the product and the need to distribute the product at the ‘street’ level. Drawing on two case studies taken from a European regulator the article details the dynamics of the market, the enterprise actions of the actors and how law enforcement responses can, in certain circumstances, make the task of the distributors easier. The traditional notions of organised crime are challenged and organisation of counterfeit alcohol markets is viewed as being reliant upon those who have legitimate access to the market and are able to develop networks of commercial collaborators who by their position in the legitimate market are able to conceal their illicit actions.     

An investigation into the use of a portable cyanoacrylate fuming system (SUPERfume®) and aluminum powder for the development of latent fingermarks

Abstract: Few techniques offer “in situ” methods of friction ridge skin mark development. “In situ” development reduces mark transportation, degradation, and often cost. The effectiveness of cyanoacrylate fuming using the SUPERfume^® and dusting with aluminum powder for latent fingermark development on several nonporous surfaces, stored in various temperature environments for time periods up to 52 weeks, was investigated. Five thousand and four hundred latent fingermarks were deposited under controlled conditions and graded. The results suggested that cyanoacrylate fuming (SUPERfume^®, Foster and Freeman, U.K.) was more effective at developing latent fingermarks on textured and smooth plastic surfaces and for marks stored in temperatures of 37°C, whereas aluminum powder was more effective on glass, enameled metal paint, and varnished wood, and for storage temperatures below 20°C. There were no significant benefits to using either technique for marks older than 24 h, but it was possible to develop fingermarks following 52 weeks of storage using both techniques.     

Detection and Identification of Psilocybe cubensis DNA Using a Real‐Time Polymerase Chain Reaction High Resolution Melt Assay,

Psilocybe cubensis, or “magic mushroom,” is the most common species of fungus with psychedelic characteristics. Two primer sets were designed to target Psilocybe DNA using web‐based software and NBCI gene sequences. DNA was extracted from eighteen samples, including twelve mushroom species, using the Qiagen DNeasy^® Plant Mini Kit. The DNA was amplified by the polymerase chain reaction (PCR) using the primers and a master mix containing either a SYBR^® Green I, Radiant? Green, or LCGreen Plus^® intercalating dye; amplicon size was determined using agarose gel electrophoresis. The PCR assays were tested for amplifiability, specificity, reproducibility, robustness, sensitivity, and multiplexing with primers that target marijuana. The observed high resolution melt (HRM) temperatures for primer sets 1 and 7 were 78.85 ± 0.31°C and 73.22 ± 0.61°C, respectively, using SYBR^® Green I dye and 81.67 ± 0.06°C and 76.04 ± 0.11°C, respectively, using Radiant? Green dye.     

Telecommunications terminal equipment: EEC commission opens the market

The 12 Member States of the European Economic Community (EEC) are legally obliged by the Treaty of Rome, as amended by the Single European Act, to abolish all of the remaining physical, technical and fiscal barriers between them by 31 December 1992. The Single European Act, which sets the 1992 deadline, defines the envisaged internal market as “an area without internal frontiers”.The creation of a common European market for telecommunications services and equipment is both an essential prerequisite and an important part of the “internal market”.In its Green Paper on the Development of the Common Market for Telecommunications Services and Equipment — “the Green Paper”¹⁾) — and a follow-up Communication²⁾, the Commission of the European Communities (“the Commission”) has set forth its main policy proposals in the telecommunications field. Implementation of these policy proposals by means of Community law directives is progressing rapidly, in particular with respect to terminal equipment. On 16 May 1988, the Commission issued a“Commission Directive on Competition in the Markets in Telecommunications Terminal Equipment” — “Terminal Equipment Directive” —³⁾ based on its regulatory powers under Art. 90(3) of the Treaty of Rome (“EEC Treaty”).This article explores the regulatory scope of the Terminal Equipment Directive which has recently been challenged by the French government before the European Court of Justice.     

The Shadow Price of Social Change and Its Evaluation

This paper analyzes the “shadow price” of social transformation. For the first time, an attempt was made to determine the approaches to measuring this value with regard to nonmarket phenomena and processes, and to apply these approaches in an empirical analysis, based on a representative survey in Russia (N = 1,000) using experimental situations.

Specifically, it quantitatively evaluates (1) the degree of divergence between the real and the ideal structure of the time budget of several important domains of social life; (2) the ratio of social ills to social benefits; (3) individual public welfare functions; and (4) the social cost, legitimated by citizens, of reproducing two fundamental public goods: “the capacity to maintain ‘superpower’ status” and “the well-being of the future generations.”

The authors introduce and operationalize the novel concept of the socially suboptimal product of labor, that is, the product resulting from alienated (or unwilling) labor, and conversely, the product that could potentially result from using unutilized willing labor. In doing so we support the idea of distinguishing productive and unproductive forms within both the notion of labor and the notion of leisure. Aggregated estimates of these values show the share of gross domestic product (GDP) that could be optimized due to a redistribution of the time budget of the population between the main areas of life, according to ideal social preferences.

The balance of social benefits and social ills resulting from the life experiences and activities of individuals is empirically evaluated. We consider this balance, which is the sum of impacts of the social environment on the individual, as a suitable model for explaining how individuals make decisions about whether or not to participate in public life.

“Individual public welfare functions” are assessed empirically, demonstrating that individual utility depends on personal and collective consumption. Empirical testing covered a wide range of nation-building areas with public investment in relevant types of merit and public goods.

Then the authors propose and test on empirical data an opportunity cost approach to evaluating socially legitimate amounts of funding for the fundamental social benefits “superpower” or “additional power” of the nation.

The cost of the public good “well-being of the future generations” is calculated for the Russian sample.

Finally, the estimates of the discount rates of human lives and “healthy and prosperous years of life” were obtained for Russia for the first time.

The findings of the study are relevant for the efficient management of complex socioeconomic systems. The authors strongly believe that revealing the structure of existing social preferences and estimating their impact on various areas of social life will help improve policymaking by explicitly taking into account the specifics of the real social contract between the state and society.     

WHEN DOES A REGULATION BECOME A TAKING? THE UNITED STATES SUPREME COURT'S MOST RECENT PRONOUNCEMENTS

Keystone Bituminous Coal, Irving, and Nollan are thus each consistent with paths taken in relevant precedents–the former two with “multifactor balancing” cases such as Penn Central and the latter with “enduring invasion equals taking” decisions such as Loretto v. TeleprompterM. However, can these twosets of precedents themselves be reconciled? I believe that the correct answer is “yes,” and that we therefore have another reason for asserting that Keystone Bituminous Coal and Nollan are consistent with each other. The tests are compatible in that the Court will first ask itself whether the regulation results in a longstanding occupation of property. If the answer is “yes,” it will declare a seizure then and there. Only if the answer if “no” will it proceed to balance.     

Selecting relevant Fourier transform infrared spectroscopy wavenumbers for clustering authentic and counterfeit drug samples

This paper proposes a novel method for selecting subsets of wavenumbers provided by attenuated total reflectance by Fourier transform infrared (ATR-FTIR) spectroscopy able to improve the clustering of medicine samples into two groups; i.e., authentic or fraudulent. For that matter, we apply principal components analysis (PCA) to ATR-FTIR data, and derive two variable importance indices from the PCA parameters. Next, an iterative variable (i.e. wavenumbers) elimination procedure and sample clustering through k-means and Fuzzy C-means techniques are carried out; clustering performance is assessed by the Silhouette Index (SI). The performance of the proposed method is compared with a greedy variable selection method, the “leave one variable out at a time” approach, in terms of clustering quality, percent of retained variables, and computational time. When applied to Viagra ATR-FTIR data, our propositions increased the average SI from 0.5307 to 0.8603 using 0.61% of the original 661 wavenumbers; as for Cialis ATR-FTIR data, clustering quality increased from 0.7548 to 0.8681 when 1.21% of the original wavenumbers were retained in the procedure. The retained wavenumbers, located in the 1091–1046 cm^− 1 region, comprise the lactose typically hailed as key substance to discriminate between authentic and counterfeit samples.     

Concretized Norm and Sanction qua Fact in the Vienna School's Stufenbaulehre

At the bottom level of the hierarchical structure (Stufenbau) of the legal system, the transition from “ought” to “is” has not been given its due. I argue that an additional level, that of fully concretized norms, belongs in the hierarchy. This sheds light on precisely where and how the transition from “ought” to “is” takes place. Whereas the fully concretized norm marks the bottom level in the hierarchy of norms, the coercive act or sanction qua fact is not found in the hierarchy, contrary to what Adolf Julius Merkl and Hans Kelsen would have us believe.     

Pig Organ Energy Loss Comparison Experiments Using BBs

Torso models for ballistics research require that the mechanical properties of simulant materials must match the heterogeneous nature of tissues/organs within the human thorax/abdomen. A series of energy loss experiments were conducted on fresh porcine organs/tissues at room temperature and 37°C, using steel 4.5 mm BBs fired from a Daisy^® brand air rifle. They were compared to FBI and NATO specification ordnance gelatin and a candidate surrogate material called Simulant “A”. Two CED M2 chronographs measured BB velocity. The resulting energy loss was established using KE = 1/2 mv² before and after target perforation. The combined results at room temperature and 37°C were as follows: FBI specification gelatin was similar (p > 0.05) to heart and lung, spleen was similar to NATO specification gelatin, Simulant “A” was similar to hindquarter muscle, and hindquarter muscle, kidney, and spleen were similar to each other regarding energy retardation. These results can be used as a basis for the development of simulant materials to create an anatomically correct heterogeneous model.     

Validation of an LC–MS Method for the Detection and Quantification of BZP and TFMPP and their Hydroxylated Metabolites in Human Plasma and its Application to the Pharmacokinetic Study of TFMPP in Humans*

Abstract: An LC–MS method was developed for benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP), constituents of “party pills” or “legal herbal highs,” and their metabolites in human blood plasma. Compounds were resolved using a mixture of ammonium formate (pH 4.5, 0.01 M) and acetonitrile (flow rate of 1.0 mL/min) with a C18 column. Calibration curves were linear from 1 to 50 ng/mL (R² > 0.99); the lower limit of quantification (LLOQ) was 5 ng/mL; the accuracy was >90%; the intra‐ and interday relative standard deviations (R.S.D) were <5% and <10%, respectively. Human plasma concentrations of TFMPP were measured in blood samples taken from healthy adults (n = 6) over 24 h following a 60‐mg oral dose of TFMPP: these peaked at 24.10 ng/mL (±1.8 ng/mL) (C_max) after 90 min (T_max). Plasma concentrations of 1‐(3‐trifluoromethyl‐4‐hydroxyphenyl) piperazine peaked at 20.2 ng/mL (±4.6 ng/mL) after 90 min. TFMPP had two disposition phases (t_½ = 2.04 h (±0.19 h) and 5.95 h (±1.63 h). Apparent clearance (Cl/F) was 384 L/h (±45 L/h).     

Whole Plastome Sequences of Two Drug-Type Cannabis: Insights Into the Use of Plastid in Forensic Analyses

DNA is one of the fastest growing tools in forensic sciences, increasing reliability in forensic reports and judgments. The use of DNA has increased in different areas of the forensic sciences, such as investigation of plant species, where plastid DNA has been used to elucidate and generate evidence in cases of traceability of genetically modified and controlled plants. Even with several advances and the practice of using DNA in forensic investigations, there are just few studies related to the identification of genetic tools for the characterization of drug and nondrug-types of Cannabis. Herein, the whole plastomes of two drug-type Cannabis are presented and have their structures compared with other Cannabis plastomes deposited in the GenBank, focusing in the forensic use of plastome sequences. The plastomes of Cannabis sativa “Brazuka” and of the hybrid Cannabis AK Royal Automatic presented general structure that does not differs from the reported for other C. sativa cultivars. A phylogenomic analyses grouped C. sativa “Brazuka” with the nondrug C. sativa cultivars, while the hybrid Cannabis AK Royal Automatic placed isolated, basal to this group. This suggests that the analysis of plastomes is useful toward genetic identification of hybrids in relation to C. sativa.