A study of the precursors, intermediates and reaction by-products in the synthesis of 3,4-methylenedioxymethylamphetamine and its application to forensic drug analysis

3,4-Methylenedioxymethylamphetamine (MDMA) was prepared by three synthetic routes. Analytical data from thin-layer chromatography, gas chromatography and gas chromatographymass spectrometry of the precursors (safrole and isosafrole), intermediates (isosafrole glycol, piperonylmethylketone, N-formyl-3,4-methylenedioxymethylamphetamine, N-formyl-3,4-methylenedioxyamphetamine and 1-(3,4-methylenedioxyphenyl)-2-bromopropane), reaction by-products and the product MDMA were obtained. Further analyses of MDMA using other techniques including ¹H- and ¹³C-nuclear magnetic resonance spectroscopy, X-ray diffraction, infrared spectroscopy, ultraviolet spectroscopy and high performance liquid chromatography were also carried out. The results were then used as reference data for the identification of MDMA in case samples and also to establish the route of synthesis of illicity prepared MDMA by the study of trace impurities.     

Pathological Features of Fatal Crocodile Attacks in Northern Australia, 2005–2014

Eleven deaths from crocodile attacks in the Northern Territory, Australia were reviewed. The male:female ratio was 8:3; age range—10–62 years, average 29.4 years. Four children were included (one boy and three girls, aged 10, 11, and two at 12 years), and there were seven aboriginal victims (64%). The attacks were witnessed in eight cases with the victims swimming in freshwater N = 5, standing on a river bank N = 1, fishing in fresh water N = 1, or diving in the sea N = 1. At autopsy, several distinct patterns of injury were observed ranging from complete traumatic disruption of the body with only incomplete remains for examination (N = 5), to crushing of the head with fractures of the skull (N = 4), crushing of the chest with fractures of the ribs and sternum (N = 2), and avulsion of limbs (N = 4). In one case, there was decapitation. Autopsy evaluations were complicated by decomposition and loss of body parts.     

Practical benzylation of N,N-substituted ethanolamines related to chemical warfare agents for analysis and detection by electron ionization gas chromatography–mass spectrometry

The benzylation of three low molecular weight N,N-disubstituted ethanolamines related to chemical warfare agents (CWAs) to furnish derivatives with improved gas chromatography-mass spectrometry (GC-MS) profiles is described. Due to their low molecular weight and polar nature, N,N-disubstituted ethanolamines are notoriously difficult to detect by routine GC-MS analyses during Organisation for the Prohibition of Chemical Weapons (OPCW) proficiency tests (PTs), particularly in scenarios when they are present at low levels (~1–10 ppm) amidst more abundant interferences. Our studies revealed that the optimal derivatization conditions involved the treatment of the ethanolamine with benzyl bromide in the presence of an inorganic base (e.g., Na₂CO₃) in dichloromethane at 55°C for 2 h. This optimized set of conditions was then successfully applied to the derivatization of N,N-dimethylethanolamine, N,N-diethylethanolamine and N,N-diisopropylethanolamine present separately at 1 and 10 μg/mL concentrations in a glycerol-rich matrix sample featured in the 48th OPCW PT. The benzylated derivatives of the three ethanolamines possessed retention times long enough to clear the massive glycerol-containing matrix interferences. The protocol herein is introduced as an alternative method for derivatization of these CWA and pharmaceutically important species and should find broad applicability in laboratories where routine forensic analysis is carried out.     

Assessment of sexual interest using a choice reaction time task and priming: A feasibility study

Purpose. We investigated the feasibility of assessing sexual interest in hetero‐ and homosexual men using two information‐processing methods, namely a choice reaction time task and priming. The participants were expected to have longer reaction times for sexually explicit when compared with non‐explicit pictures due to sexual content‐induced delay. In addition, the reaction times of the heterosexual (N=15) and homosexual (N=11) men for pictures corresponding with their sexual interest were compared to pictures not corresponding with their sexual interest. Heterosexual men were expected to have longer reaction times during the presentation of sexually explicit female as opposed to male pictures, whereas homosexual men were expected to have the opposite pattern. Method. The participants were presented either sexually explicit or non‐explicit male and female target pictures (and primes that preceded the targets in random combinations) while simultaneously performing a choice reaction time task in three phases each containing a total of 160 prime–target pairs. Results. Both expectations were confirmed in phase 1 of the study. In phase 2, the means differed in the expected way, but the effects were not significant. In phase 3, the expected effect was moderated by a complex priming effect. Conclusions. The results suggest that the choice reaction time task is a promising way of measuring sexual interest but that questions of habituation should be given more attention in future studies.     

Measuring interrogative suggestibility in children: Reliability and validity of the bonn test of statement suggestibility

Abstract

The present paper describes three studies that examined false confessions in the laboratory. Studies 1 (N=56) and 2 (N=9) relied on the by now classic computer crash paradigm introduced by Kassin and Kiechel (Psychological Science, 7, 125–128, 1996). Study 3 (N=12) employed a novel paradigm in which undergraduate participants were falsely accused of exam fraud. Our data indicate that false confessions do occur, even when conditions become more ecologically valid. Furthermore, we explored whether individual differences in compliance, suggestibility, fantasy proneness, dissociation, and cognitive failures are related to false confessions. Of these, only fantasy proneness was associated with false confessions.     

Human eye colour and HERC2, OCA2 and MATP

Prediction of human eye colour by forensic genetic methods is of great value in certain crime investigations. Strong associations between blue/brown eye colour and the SNP loci rs1129038 and rs12913832 in the HERC2 gene were recently described. Weaker associations between eye colour and other genetic markers also exist. In 395 randomly selected Danes, we investigated the predictive values of various combinations of SNP alleles in the HERC2, OCA2 and MATP (SLC45A2) genes and compared the results to the eye colours as they were described by the individuals themselves. The highest predictive value of typing either the HERC2 SNPs rs1129038 and/or rs12913832 that are in strong linkage disequilibrium was observed when eye colour was divided into two groups, (1) blue, grey and green (light) and (2) brown and hazel (dark). Sequence variations in rs11636232 and rs7170852 in HERC2, rs1800407 in OCA2 and rs16891982 in MATP showed additional association with eye colours in addition to the effect of HERC2 rs1129038. Diplotype analysis of three sequence variations in HERC2 and one sequence variation in OCA2 showed the best discrimination between light and dark eye colours with a likelihood ratio of 29.3.     

Estimating Time Since Death from Postmortem Human Gut Microbial Communities

Postmortem succession of human‐associated microbial communities (“human microbiome”) has been suggested as a possible method for estimating postmortem interval (PMI) for forensic analyses. Here we evaluate human gut bacterial populations to determine quantifiable, time‐dependent changes postmortem. Gut microflora were repeatedly sampled from the proximal large intestine of 12 deceased human individuals as they decayed under environmental conditions. Three intestinal bacterial genera were quantified by quantitative PCR (qPCR) using group‐specific primers targeting 16S rRNA genes. Bacteroides and Lactobacillus relative abundances declined exponentially with increasing PMI at rates of N_t = 0.977e^?0.0144t (r² = 0.537, p < 0.001) and N_t = 0.019e^?0.0087t (r² = 0.396, p < 0.001), respectively, where N_t is relative abundance at time (t) in cumulative degree hours. Bifidobacterium relative abundances did not change significantly: N_t = 0.003e^?0.002t (r² = 0.033, p = 0.284). Therefore, Bacteroides and Lactobacillus abundances could be used as quantitative indicators of PMI.     

Bhartṛhari and Maṇḍana on Avidyā

The concept of avidyā is one of the central categories in the Advaita of Śaṇkara and Maṇḍana. Shifting the focus from māyā, interpreted either as illusion or as the divine power, this concept brings ignorance to the forefront in describing duality and bondage. Although all Advaitins accept avidyā as a category, its scope and nature is interpreted in multiple ways. Key elements in Maṇḍana’s philosophy include the plurality of avidyā, individual selves as its substrate and the Brahman as its field (viṣaya), and the distinction in avidyā between non-apprehension and misapprehension. A closer investigation shows that Maṇḍana is directly influenced by Bhartṛhari’s linguistic non-dualism in developing the concept of avidyā. This study also compares other key constituents such as vivartta and pariṇāma that are relevant to the analysis of avidyā. As the concept of counter-image (pratibimba) emerges as a distinct stream of Advaita subsequent to Maṇḍana, this study also compares the application of pratibimba in the writings of Bhartṛhari and Maṇḍana.     

Procedural Justice in Majority–Minority Relations: Studies Involving Belgian Linguistic Groups

Two studies investigated perceptions of fairness of two modes of group representation in a political assembly. The numerical status of two Belgian linguistic groups (Dutch-speaking vs. French-speaking) was predicted to influence these perceptions: The minority finding equality fairer and proportionality less fair than the majority. These preferences were investigated at two levels of comparison, Belgium and Brussels, Dutch speakers being numerically a majority in Belgium and a minority in Brussels. The results of two studies (N = 52 and N = 127, respectively) revealed that the expected trend was present, especially at the level of Brussels. A third study (N = 103) suggested that minorities and majorities could be driven by different motives with trust in the out-group being a powerful predictor of minorities' choices, whereas group identification predicted majorities' preferences.     

Validity and reliability of the Self-Report Delinquency among a sample of at-risk youths

Self-Report Delinquency scales have formed the basis of much understanding of juvenile delinquency today, but further improvement and extensive measurement research on self-report measures of crime are needed. The present study examined the psychometric properties of the shorter general delinquency scale version of the classic commonly used Self-Report of Delinquency (SRD) measure created for the original National Youth Survey (NYS) using a sample (N = 412) of male (n = 200) and female (n = 212) at-risk Portuguese youths. The shorter version of the SRD demonstrated satisfactory validity and reliability, namely in terms of its latent one-factor structure, internal consistency, convergent validity, divergent validity, concurrent criterion validity and discriminant groups validity that overall justifies its use among this population. The shorter general delinquency scale version of the SRD is a valid and reliable measure from a modern psychometric perspective that can be used with at-risk youths.     

The removal of institutional impediments to migration and its impact on employment,production and income distribution in China

The major objectives of this article are to identify the inter-regional and inter-sector wage differentials that are attributed to the institutional restriction on labor mobility (the hukou system), and then to simulate the impact that the removal of the restriction would have on the Chinese economy. Our simulation results reveal that the removal of the hukou system would be accompanied by a massive migration to cities. The degree by which the labor force would decrease with the removal of the hukou system is higher in rural industry than in agriculture, suggesting that the absence of job qualifications would prevent the vast majority of farmers from changing their occupations. Should off-farm employment opportunities in cities for rural migrants be rationed, the elimination of the hukou system would exacerbate rather than cure the problem of unemployment in urban labor markets, which would adversely affect distributional consequences at the national level.

The Effects of a Police/Victim Assistance Crisis Team Approach to Domestic Violence

A police/victim assistance crisis intervention program was evaluated over a 6-month period for its effect on police-related outcomes. Police report data on crisis team cases (N = 96) were compared to a random selection of family violence cases (N = 80) that were not served by the crisis team. The crisis team cases generated more arrests; however, victim cooperation was lower than in noncrisis intervention cases. Implications for work with family violence and victim assistance are discussed, as well as needs for future research.     

Motivational interviewing with offenders: A systematic review

Purpose. Offender motivation is one specific responsivity variable in offender treatment and motivational interviewing (MI) is commonly used by corrections personnel. Although evidence for the effectiveness of motivational interviewing is accruing overall, a review of MI specifically with offender populations is required. Method. Relevant databases and websites were searched using terms relating to MI with offenders. Results. In total, 13 published studies and 6 dissertation abstracts were identified. MI is most evaluated in relation to substance misusing offenders (N=10). Other applications are with domestic violence offenders (N=3), drink‐drivers (N=5), and general offending (N=1). In these populations, MI is used to enhance retention and engagement in treatment, improve motivation for change, and change behaviour. Conclusions. MI can lead to improved retention in treatment, enhanced motivation to change, and reduced offending, although there are variations across studies. To advance the study of MI with offenders, a theory of change needs to be articulated on which testable hypotheses may be based. The integrity of treatment in its application needs to be assured. Based on these foundations, more outcome research is needed to examine who responds to what type of MI in relation to treatment retention, readiness to change, and reconviction.     

Legal professionals’ knowledge and experience of autistic adults in the family justice system

Abstract

Access to justice is a key theme in the family justice system, especially for those with particular vulnerabilities. Autism, a development condition characterised by difficulties in social communication and interaction, and the presence of rigid, repetitive behaviours, presents particular challenges in this area. This paper reports the findings of a mixed-methods study with legal professionals working in the family justice system, asking about their knowledge of autism, their perceived self-efficacy when working with autistic clients, and their experience of cases involving autistic litigants. The study reports high levels of knowledge, but low levels of confidence, by legal professionals (N = 204), and addresses the experiences of particular cases in follow-up discussions (N = 10). The paper concludes by making a series of recommendations for legal professionals to assist autistic people to engage fully in family court proceedings.     

Shortened versions of the Gudjonsson Suggestibility Scale meet the standards

Purpose. The Gudjonsson Suggestibility Scale (GSS; Gudjonsson, 1984, 1997 ) is a well‐established forensic tool for measuring interrogative suggestibility. However, one restriction of this tool is that it requires an extensive testing procedure. The present study examined whether shorter versions of the GSS yield similar results as the original GSS procedure. Methods. One group (N=20) was given a shortened version of the GSS that consisted of an immediate recall test and the specific questions. GSS scores in this group were compared with those in a group (N=20) that had the standard procedure which includes a retention interval and immediate and delayed recall tests. A third group (N=20) was administered a shortened procedure in which the 20 GSS questions immediately followed the GSS story. In the fourth group (N=20), participants were given the retention interval, but no recall tests were administered. Results. ANOVA showed no differences in GSS scores amongst the four groups. Post hoc power analyses indicated that these non‐significant findings were not the result of a power problem and that larger sample sizes are expected to yield comparable results. Further analyses showed that neither the retention delay nor the recall tests affected suggestibility scores. Conclusions. These results suggest that shortened procedures for administering the GSS may be employed in situations where time is a key factor.     

The Process Matters: Fairness in Repository Siting For Nuclear Waste

Siting contested infrastructure such as repositories for nuclear waste very often faces strong local resistance. One major reason for this opposition may arise because siting processes do not appropriately consider fairness issues such as transparency, the availability of options, or the sufficient involvement of concerned and affected people. The aim of this study was to analyze people’s concerns related to justice in siting nuclear waste. Besides procedural aspects, both distributive justice and outcome valence are considered important and therefore the “total fairness model” by T?rnblom and Vermunt (Soc Justice Res 12:39–64, 1999) was used as a framework. In three quasi-experimental studies (N ₁ = 53; N ₂ = 56; N ₃ = 83) applying conjoint analysis, respondents ranked 11 vignettes with the three attributes procedural justice, distributional justice, and outcome valence. Each vignette represents a realistic scenario of a site selection process for the disposal of nuclear waste in Switzerland. All the three studies yield a consistent result: vignettes representing a situation with a fair process are top-ranked by respondents; situations with negative outcome valence are ranked lowest; distributive issues turned out to be of minor importance. We conclude that procedural fairness should be given more attention in any kind of contested infrastructure siting and that real-world examples like the one discussed here can inform justice research.     

MENTAL DISORDER AND VIOLENT VICTIMIZATION: THE MEDIATING ROLE OF INVOLVEMENT IN CONFLICTED SOCIAL RELATIONSHIPS*

This study examines whether the relationship between mental disorder and violent victimization is attributable to the disproportionate involvement of mentally disordered people in conflicted social relationships. The data consist of a sample of discharged psychiatric patients (N= 270) and a sample of nonpatients (N= 477) drawn from the same neighborhoods. Results show that mentally disordered patients were more likely to be victimized by violence and to be involved in conflicted social relationships. Moreover, involvement in conflicted social relationships mediated the effect of mental disorder on violent victimization, a result that held when illegal drug use by the patients was taken into account. Implications for research and theory are discussed.     

The Mūlāvidyā Controversy Among Advaita Vedāntins: was Śaṅkara Himself Responsible?

The concept of avidyā or ignorance is central to the Advaita Vedāntic position of Śȧnkara. The post-Śaṅkara Advaitins wrote sub-commentaries on the original texts of Śaṅkara with the intention of strengthening his views. Over the passage of time the views of these sub-commentators of Śaṅkara came to be regarded as representing the doctrine of Advaita particularly with regard to the concept of avidyā. Swami Satchidanandendra Saraswati, a scholar-monk of Holenarsipur, challenged the accepted tradition through the publication of his work Mūlāvidyānirāsaḥ, particularly with regard to the avidyādoctrine. It was his contention that the post-Śaṅkara commentators brought their own innovations particularly on the nature of avidyā. This was the idea of mūlāvidyā or ‘root ignorance’, a positive entity which is the material cause of the phenomenal world. Saraswati argues that such an idea of mūlāvidyā is not to be found in the bhāṣyas (commentaries) of Śaṅkara and is foisted upon Śaṅkara. This paper attempts to show that although Śaṅkara may not have explicitly favoured such a view of mūlāvidyā, his lack of clarity on the nature of avidyā left enough scope for the post-Śaṅkara commentators to take such a position on avidyā.