The development of drug trade and drug control in the Netherlands: a historical perspective

Drug trade is widely seen as a phenomenon rather new to the Netherlands. However, at the beginning of the 20th century the Dutch pharmaceutical industries were already extensively involved in the production of both opiates and cocaine, and they went on exporting large quantities of these drugs after the Opium Act (1919) took force. Until the 1960s, arrests were not at all common, and these largely affected minority groups like Chinese opium smokers and black marijuana users. Since then, drug control efforts have increased by leaps and bounds. At first, cannabis was the main target; then the focus turned to heroin, and that was later joined by cocaine. This paper traces the history of the drug trade and drug control in the Netherlands, with emphasis on their development in Amsterdam. The conclusion is reached that, in spite of drastic changes in both drug trade and drug control, certain ideologies, constructs and strategies have remained remarkably stable.     

Cultural heritage conservation during emergency management: luxury or necessity?

Annually, natural disasters cause loss of life, damage to property, and damage to the environment. Concomitant is damage to the cultural heritage property, both items and places. Yet in the wake of a disaster, containment and response efforts put additional cultural resources at risk--usually due to ignorance rather than malice on the part of the disaster manager or the property owners. This paper reviews the effects of natural disasters on heritage sites and argues for increased awareness and training for disaster managers.     

Injury pattern in fatal automobile accident passengers due to rear-end collisions

The article reports on the injury pattern seen in fatally wounded car passengers after rear-end collisions on motorways. The study material included 5 rear-end collisions, in which 9 car occupants (5 drivers and 4 front-seat passengers) were killed. The change in velocity (delta v) was above 60 km/h in all the reported cases. The injury pattern showed the following characteristics: extensive soft-tissue traumatization (subcutaneous haematomas, blood-filled pockets, "décollements") not discernible from outside on the back of the trunk, mostly in the lumbosacral region; dorsal serial rib fractures, often combined with fractures of the spine (including the sacrum and the coccyx) and/or the pelvis; ruptures of the aorta at the typical sites of predisposition; ruptures of the liver and spleen (particularly at the visceral surfaces).     

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The national impact of European Union regulatory policy: Three Europeanization mechanisms

Abstract. While much has been written about the impact of European Union (EU) regulatory policy, most of the scholarly work is concerned with developments at the European level. Only recently have attempts been made to fill this gap. Although there is a growing number of studies explicitly concerned with the Europeanization of domestic institutions, we still lack consistent and systematic concepts to account for the varying patterns of institutional adjustment across countries and policy sectors. The aim of this article is to provide a more comprehensive framework for explaining the domestic impact of European policy making. We make an analytical distinction between three mechanisms of Europeanization – institutional compliance, changing domestic opportunity structures, and framing domestic beliefs and expectations – each of which requires a distinctive approach in order to explain its domestic impact. We argue that it is the particular type of Europeanization mechanism involved rather than the policy area itself that is the most important factor to be considered when investigating the domestic impact of varying European policies.     

Semi-automated ultrasound facial soft tissue depth registration: method and validation

A mobile and fast, semi-automatic ultrasound (US) system was developed for facial soft tissue depth registration. The system consists of an A-Scan ultrasound device connected to a portable PC with interfacing and controlling software. For 52 cephalometric landmarks, the system was tested for repeatability and accuracy by evaluating intra-observer agreement and comparing ultrasound and CT-scan results on 12 subjects planned for craniofacial surgery, respectively. A paired t-test evaluating repeatability of the ultrasound measurements showed 5.7% (n = 3) of the landmarks being significantly different (p < 0.01). US and CT-scan results showed significant differences (p < 0.01) using a Wilcoxon signed rank test analysis for 11.5% (n = 6) of the landmarks. This is attributed to a difference in the volunteer's head position between lying (CT) and sitting (US). Based on these tests, we conclude that the proposed registration system and measurement protocol allows relatively fast (52 landmarks/20 min), non-invasive, repeatable and accurate acquisition of facial soft tissue depth measurements.     

Automated headspace solid-phase dynamic extraction for the determination of cannabinoids in hair samples

This article describes a fully automated procedure for detecting cannabinoids in human hair samples. The procedure uses alkaline hydrolysis and headspace solid-phase dynamic extraction (HS-SPDE), followed by on-coating derivatization and gas chromatography-mass spectrometry (GC-MS). SPDE is a further development of solid-phase microextraction (SPME), based on an inside needle capillary absorption trap. It uses a hollow needle with an internal coating of polydimethylsiloxane as extraction and pre-concentration medium.Ten mg of hair were washed with deionised water, petroleum ether and dichloromethane. After adding deuterated internal standards, the sample was hydrolyzed with sodium hydroxide and directly submitted to HS-SPDE. After absorption of analytes for an on-coating derivatization procedure, the SPDE-needle was directly placed into the headspace of a second vial containing N-methyl-N-trimethylsilyl-trifluoroacetamide before GC-MS analysis. The limit of detection was 0.14 ng/mg for Delta(9)-tetrahydrocannabinol, 0.09 ng/mg for cannabidiol, and 0.12ng/mg for cannabinol. Absolute recoveries were in the range of 0.6 to 8.4%. Linearity was verified over a range from 0.2 to 20 ng/mg, with coefficients of correlation between 0.998 and 0.999. Intra- and inter-day precision were determined at two different concentrations and resulted in ranges between 2.3 and 6.0% (intra-day) and 3.3 and 7.6% (inter-day). Compared with conventional methods of hair analysis, this automated HS-SPDE-GC-MS procedure is substantially faster. It is easy to perform without using solvents and with minimal sample quantities, and it yields the same sensitivity and reproducibility. Compared to SPME, we found a higher extraction rate, coupled with a faster automated operation and greater stability of the device.     

The social construction of international institutions: the case of ASEAN + 3

Slowly but steadily, a new international institution is emergingin East Asia: the ASEAN + 3 forum, comprising the ten membersof the Association of Southeast Asian Nations (ASEAN) plus China,Japan and South Korea. ASEAN + 3 is an interesting case of institution-buildingin that it is constructed around the core of an already existinginstitution, ASEAN, which was founded in 1967. The followinganalysis of this multilateral forum seeks to answer two theoreticalquestions: (i) Why do states cooperate? (ii) What happens totheir interests and identities once they communicate with eachother? In view of this task, I will offer a social constructivistvariant of international relations theory to explain the instigationof the process on the one hand and the processual constructionof the institution on the other. The underlying belief is thatnot only do states influence the development of internationalinstitutions, but that institutions can also exert influenceon foreign policy behaviour. The approach introduced here acknowledges that internationalreality is a social construction driven by collective understandingsemerging from social interaction. This approach to the explanationof the initiation and the subsequent development of an institutionrecognizes the existence of both material and normative groundsof foreign policy action. It differs from neoliberal institutionalismbecause in this theory as well as in realism collective interestis assumed as pre-given and hence exogenous to social interaction.In contrast, we suppose that social interaction ultimately doeshave transformative effects on interests and identity, becausecontinuous cooperation is likely to influence intersubjectivemeanings. This method of analysis corresponds with Moravscik'stripartite analysis of integration decisions: while the initialphase refers to the formation of state preferences, the secondand third involve the dynamic aspect of ‘constructing’international institutions: the outcomes of interstate bargainingand the subsequent choice of the institutional design.     

Fatalities after injuries by wild animals

The article summarises three fatalities after attacks by wild animals. The first case describes a 90-year-old woman who died as a result of pneumonia after a bear fell on her and caused multiple chest fractures. The second case deals with a 76-year-old woman who was hit in the middle face by the hoof of a camel and, thereafter, died of myocardial infarction. The third case describes a 27-year-old biologist who died from severe blunt trauma after an attack of a wild living elephant. The article gives a summary of typical injury patterns of selected wild animals and outlines potential reasons of death as a result of the injuries.