Immunohistochemical study of blood group activities in the alimentary canal in normal and pathologic conditions with reference to the nature of epithelial mucopolysaccharides

ABO(H)- and Lewis-activities in the human alimentary canal were investigated by the avidin-biotin-peroxidase complex method using commercial mouse monoclonal antibodies in order to clarify (1) the changes apparent in these activities in carcinoma of the digestive tract or premalignant intestinal metaplasia of the stomach and (2) the relationship of the activities to the histochemical properties of epithelial mucins examined by Alcian blue (pH 2.5)/periodic acid-Schiff (PAS) double staining. In intestinal metaplasia, ectopic goblet cells showed various degrees of ABO(H)-activities according to the PAS stainability of mucins and revealed Lea-activity even in a Le(a-b+) group. In carcinoma of the alimentary canal, ABO(H)- and Lewis-activities compatible with the donors' blood groups were located mainly at the PAS-positive cell surface, and in the Golgi bodies and secretions. It was thus concluded that quantitative and/or qualitative changes in blood group activities were closely associated with those of epithelial mucopolysaccharides.     

Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year

The autopsy findings of an adult patient with 21-hydroxylase deficiency are presented. Genetic analysis of the 21-hydroxylase gene (CYP21A2) was performed for accurate diagnosis of congenital adrenal hyperplasia (CAH), and bilateral testicular tumors were characterized. We report a 29-year-old Japanese man who was diagnosed with CAH (21-hydroxylase deficiency) in infancy and had continued steroid therapy until the age of 28. However, for more than one year, he had not been treated for CAH and was found dead. In the medico-legal autopsy findings, both adrenal glands were enlarged, and hypertrophy of adrenal cortices and bilateral testicular tumors positive for melan-A were observed. Genomic DNA was prepared from cervical lymph nodes collected during autopsy, and CYP21A2 was PCR amplified and sequenced directly using newly designed primers. From the morphological findings, the bilateral testicular tumors were considered to be adrenogenital syndrome (TTAGS). Through the whole sequence of CYP21A2, the intron 2 splice mutation (656)A to (656)G was found. TTAGS were thought to be adrenal rests enlarged by ACTH stimulus. From the autopsy findings and the result of genetic analysis, he was diagnosed with the salt-wasting form of 21-hydroxylase deficiency and his cause of death was presumed to be heart failure based on abnormal electrolytes.     

Discourses of the Vanishing: Modernity,Phantasm, Japan by Marilyn Ivy

Abstract

Discourses of the Vanishing has been anticipated for several years now; it won't disappoint. Despite the rising number of authors who seek to “explain” Japan or attack its essentialism, Ivy is one of the few who have the understanding of modernity and the methodological tools to excavate the celebration (Japanese and American) of Japan's “uniqueness.” Discourses is by far one of the most sophisticated inquiries into what Ivy calls—properly I believe—the “Japanese thing.” The juxtaposition between the singular, thing, and plural, discourses, suggests her overall theme: to discuss the always incomplete reconfigurations of the many pasts that have existed within the archipelago into a singular ideology of Japan.     

Feminist Reading(s) and reading into feminist theory

Abstract

Let me confess in the beginning that I am a latecomer to the field of feminist literary criticism. Having left academia (or, more accurately, never really becoming part of it-the position I got two years after receiving my Ph.D. was one of raising two children), I was introduced to feminist criticism in the mid-1980s, a few years after I wrote the introduction to This Kind of Woman on which the review “Reading Women's Texts” concentrates. I have found feminist literary criticism intellectually stimulating and emotionally satisfying. I found the intellectual stimulation similar to what I had experienced after being introduced to the theories of Freud and Erikson. Indeed, my basic framework for understanding human behavior is colored by those theories I have learned earlier. I am quite willing, however, to apply new theories that would work against the old ones as long as such applications open up new terrain in literary interpretation. On the other hand, it is not a good practice with literary criticism to place a theory ahead of works and to try to force a theoretical position on them. In this response to the review I will therefore try to defend my position without rejecting the notion that there are new worthwhile readings of the stories, that is, that some corrections and modifications of the original reading may be possible and desirable.     

Hippocampal Agenesis in an Individual who Engaged in Violent Criminal Behaviors After Discontinuing Carbamazepine and Paroxetine Treatment

Antidepressant discontinuation syndrome (ADS) occurs after abrupt discontinuation of an antidepressant medication. A 23‐year‐old man with right hippocampal agenesis demonstrated sexual crime (hypersexuality) since the age of eight and had been successfully treated with carbamazepine since the age of 13. He had required increased doses of paroxetine and carbamazepine owing to the development of an unstable affect after quitting his job. He abruptly stopped taking his medication for 3 days and his criminal behaviors re‐emerged. We examined changes in brain structure and activity before and after medication cessation, using MRI and functional MRI (fMRI). The image of a girl in a swimsuit increased activity in the thalamus only after medication discontinuation. The alteration in thalamic activity might induce hypersexuality. We conclude that a primary hypersexuality had been suppressed with carbamazepine and paroxetine treatment, and the discontinuation of the medication caused the hypersexuality.     

A new triplex STR system without irregular alleles by silver staining and its potential application to forensic analysis

In order to increase the discriminating power of DNA analysis in forensic science, we devised a new triplex STR system using three novel STR loci we previously reported, D14S299 (wglc5), D15S233 (wgldl), and 9q2h2. We designated this system a CDH triplex system. The CDH triplex system showed a high discriminating power, especially in Caucasians. This system is composed of three STR loci showing only regular tetranucleotide repeat alleles. We easily enlarged the databases mainly of Japanese, using this system, and compared them with those of Caucasian and Chinese. This CDH triplex system therefore appears to be useful for forensic practice.     

Japan's Policy for East Asia

Japanese foreign policy six decades after the end of World War II stands at a crossroads. The forces of globalization and the rise of the BRIC nations (Brazil, Russia, India, and China) seem to herald the end of the unipolar post-Cold War international system and the emergence of a new era defined by multi-polarity and multilateralism. Such global trends are manifest most clearly in Japan's own backyard, where phenomenal region-wide economic growth, a gradual redistribution of power (in particular the rise of China and India), and the increasingly important role of multilateral cooperation and regional institutions are dramatically transforming East Asia. This trend shows no signs of slowing down, much less reversing itself; nor would it be in Japan's interest to pursue any policy that seeks to do so. Nevertheless, the transformation itself remains almost on auto-pilot, lacking a clear long-term guiding vision. After presenting a brief overview of Japan's past policy toward the region, the goal of this paper will be to articulate such a vision through a series of policy proposals through which to ensure future peace, stability, and prosperity in East Asia.     

Public Resource Allocation and Electoral Systems in the U.S. and Japan

This paper introduces alternative measures of net budgetallocation and legislative representation. They are neutral tothe size of total expenditure and tax collection as well as tochanges in the population and the size of the legislature,which makes them suitable for panel data exercises andinternational comparative studies. Regression analyses of 50U.S. states and 47 Japanese prefectures using these indiceshighlight similarities and differences in public resourceallocation between respective democracies that reflect theirpolitical and electoral systems.     

In pursuit of universal values

Is universality inherent in freedom and human rights? Yes, says Keijiro Tanaka, trustee and senior advisor at IIPS. Only democratic systems of government embodying constitutional liberalism can safeguard the freedoms and rights of their citizens, and the spread of democracy offers the best chance for ensuring a peaceful world. However, freedoms and rights must go hand in hand with duties and responsibilities, and Tanaka argues for codifying these in a document which would supplement and support the Universal Declaration of Human Rights. He says “Asian values” as championed by some Asian leaders do not have the same universal quality as the rights and freedoms set forth in the Universal Declaration of Human Rights, because they are traditional moral precepts or social virtues that can be used for both good and evil. He feels Japan should be more responsible in the pursuit of universal values which are shared by all other liberal democracies.     

Egocentric bias in perceived fairness: Is it observed in Japan?

Experiment 1 was a Japanese replication of the studies reported by Messicket al. (1985) and Liebrandet al. (1986). Subjects were asked to write down fair or unfair behaviors that they or others did, giving as many examples as possible in 5 min. As in the previous studies, the subjects began more fair behaviors with the word I than with others. Likewise, they began more unfair behaviors with the word others than with I. In Experiment 2, 80 examples of behaviors (40 fair and 40 unfair) were selected randomly from the results of Experiment 1. The difference between the number of frequent behaviors sorted into the fair/I category and that sorted into the unfair/I category was greater than that between the number of behaviors sorted into the fair/others and that sorted to be unfair/others. Salient behaviors were more likely to be sorted into the category of unfair than into fair, and more likely to be sorted into others than I. On the whole, the egocentric bias of fairness was confirmed in Japan as well as in the Netherlands and the United States. However, in both experiments, gender differences were found; women, compared to men, recalled more others' behavior than their own and were likely to attribute fair and/or unfair behavior to others rather than to themselves.