Is Corporate Social Responsibility a Constructivist Regime? Evidence from Latin America

The paper argues that the emerging norms on corporate social responsibility (CSR) can be theorised as a constructivist regime, specifically a subset of private authority regimes—a transnational private legitimacy regime. The purpose of this regime is the transnational legitimation of globalised private accumulation strategies. It hypothesises that CSR acts as a framework of principles, norms and practices that enables communication, negotiation and contestation between civil society organisations (CSOs) and transnational corporations about the social impact of foreign investment. The regime inadvertently transforms the terrain on which businesses interact with other actors from one of power (where business was clearly dominant) to a terrain of (at least partial) legitimacy. This implies that actors that control “legitimacy resources”, such as CSOs, should see their negotiating power increase vis-à-vis businesses. The paper examines these conjectures through a case study of CSR promotion and advocacy in Latin America.     

Legislative Capacity and Executive Unilateralism

This article develops a theory of presidential unilateralism in which both ideological divergence with Congress and legislative capacity influence the president's use of executive orders. We argue that when Congress is less capable of constraining the executive, the president will issue more executive orders during periods of divided government. Conversely, in periods of high legislative capacity, the president is less likely to issue executive orders when faced with an opposed Congress. Based on an examination of institutional changes, we identify years prior to the mid‐1940s as characterized by low congressional capacity and the subsequent period as characterized by high capacity. Testing the theory between 1905 and 2013, we find strong support for these predictions and demonstrate that legislative capacity conditions the role of ideological disagreement in shaping presidential action. Overall, this article deepens our current understanding of the dynamics of separation‐of‐powers politics and the limits of executive power.     

Inertia of the State Power Hierarchy

Russian regional policy in 2015 was focused on the continued dismantling of the modest political reforms introduced during the Medvedev presidency. These changes were implemented in order to minimize the possibility of the emergence and strengthening of new independent political players, and the resultant institutional imbalance toward centralization at the regional level was merely a side effect of this effort. The net effect has been a major strengthening of the power of governors at the expense of all other political actors at the regional level. The governors' power will now only be checked by federal oversight.     

Responsible research and innovation training programmes: implementation and evaluation of the HEIRRI project

Responsible research and innovation, or RRI, is a concept that aims to bring together society and science for a better future. There are six key elements of RRI: public engagement, gender equality, science education, open access, ethics and governance. Higher Education Institutions and Responsible Research and Innovation (HEIRRI) project aimed to bring the concept of RRI into the educational system. Using state-of-the-art review of good practices, HEIRRI team developed 10 training programmes on RRI for different higher education institution educational levels, including a summer school and a massive open online course (MOOC). We conducted pilot of the trainings and evaluated participants' experiences. Satisfaction with HEIRRI training programmes on responsible research and innovation was high, both for participants and for the trainers, and trainings raised awareness of RRI. Participants' feedback was used to identify areas that need improvement and provided for recommendations for final versions of the HEIRRI training programmes. In order to equip researchers with skills to recognize and apply RRI values, RRI should be included in their education. HEIRRI training is suitable for a range of different disciplines, including forensic science, and is free to use and adjust for specific contexts (available from: https://rri-tools.eu/heirri-training-programmes).     

Synthesis,structure, in vitro pharmacology,and in vivo activity of trans-3,4-dichloro-N-[[1-(dimethylamino)-4-phenylcyclohexyl]methyl]-benzamide (AP01; 4-phenyl-AH-7921), a novel mixed μ-/κ-opioid

Analogs of non-fentanyl novel synthetic opioids (NSO) with modifications that fall outside of established structure–activity relationships (SARs) for that class of drugs create the question whether or not it should be considered an analog, as defined by 21 U.S.C. §802(32)(A), which is important for its inclusion in the US system of drug scheduling. AH-7921 is a US Schedule I drug and an example of the 1-benzamidomethyl-1-cyclohexyldialkylamine class of NSO. The SARs regarding substitution of the central cyclohexyl ring have not been well characterized in the literature. Therefore, in order to expand the SAR surrounding AH-7921 analogs, trans-3,4-dichloro-N-[[1-(dimethylamino)-4-phenylcyclohexyl]methyl]-benzamide (AP01; 4-phenyl-AH-7921) has been synthesized, analytically characterized, and tested in vitro and in vivo pharmacologically. Using methods described in the original patents for this class of NSO, it was found that the single trans geometric isomer was obtained. The proton nuclear magnetic resonance, mass spectrum, infrared spectrum, and Raman spectrum are reported along with the melting point of the hydrochloride salt. In vitro binding to a battery of 43 central nervous system receptors showed it to be a high-affinity μ-opioid receptor (MOR) and κ-opioid receptor (KOR) ligand (60 nM and 34 nM, respectively). AP01 also had a 4 nM affinity for the serotonin transporter (SERT), which is a higher level of potency at this receptor than most other opioids. In rats, it exhibited antinociception in the acetic acid writhing test. Therefore, the 4-phenyl modification results in an active NSO, but carries with it potential toxicities beyond those expected for currently approved opioid drugs.