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111.
This article considers whether children born through assisted human reproduction are entitled to information about their biological origins. It examines the issue both from a clinical perspective, citing social science research and the personal narratives of donor‐conceived children, and from a legal perspective, outlining the extent of a child's “right to know” in different jurisdictions. The article suggests that a uniform legal approach is needed that will recognize the right of all children to access details about their identity and conception, for the sake of their psychological well‐being. The article includes a fact scenario that considers the situation of a donor‐conceived child who has become the subject of a custody dispute, and who has not been told the circumstances of his conception.  相似文献   
112.
Forensic DNA typing is currently conducted in approximately 8–10 h. The process includes DNA extraction, quantitation, multiplex PCR amplification, and fragment length detection. Today's commercial multiplex short tandem repeat (STR) typing kits are not optimized for rapid PCR thermal cycling. Current protocols require approximately 3 h for amplifying a multiplex containing 15 STR loci plus amelogenin. With the continuing development of miniaturization technologies such as microfluidic and micro-capillary devices, there is a desire to reduce the overall time required to type DNA samples. Such miniature devices could be used for initial screening at a crime scene, at a border, and at airports. There is also the benefit of reducing the required PCR amplification time for labs typing single-source reference samples. Surveys of fast processing polymerases working in combination with rapid cycling protocols have resulted in the development of a ‘rapid’ PCR amplification protocol. Results are obtained in less than 36 min run on a standard peltier-based thermal cycler employing a heating rate of 4 °C/s. Capillary electrophoresis characterization of the PCR products indicates good peak balance between loci, strong signal intensity and minor adenylation artifacts. Genotyping results are concordant with standard amplification conditions utilizing a standard 3 h (non-rapid) thermal cycling procedure. The rapid assay conditions are robust enough to routinely amplify 0.5 ng of template DNA (with 28 cycles).  相似文献   
113.
Abstract: A short tandem repeat multiplex assay has been successfully developed with 25 autosomal loci plus the sex‐typing locus amelogenin for a total of 26 amplified products in a single reaction. Primers for the loci were designed so that all of the amplicons present were distributed from 65 base pairs (bp) to less than 400 bp within a five‐dye chemistry design with the fifth dye reserved for the sizing standard. A multiplex design strategy was developed to overcome challenges encountered in creating this assay. The limits of the multiplex were tested, resulting in the successful amplification of a wide range of genomic DNA sample concentrations from 2 ng to as low as 100 pg with 30 cycles of PCR. The 26plex has the potential to benefit the forensic community for reference sample testing and complex relationship evaluation.  相似文献   
114.
Much has been written about the nature of Australian nationalism during the late nineteenth and early twentieth centuries. While post-Second World War historiography analysed the role of class in nationalist sentiment, more recent work has examined the racialised and martial aspects of Australian nationalism and imperialism. There has been less consideration of how the nature of turn-of-the-century Australian nationalism affected the Federation that was established on 1 January 1901. This article examines early debates about commemoration of the anniversary of Federation, revealing an indifference to the occasion that was common to the public and most political and civic leaders, including Prime Minister Edmund Barton. It finds that popular enthusiasm at the inauguration of the Commonwealth in January 1901 and the opening of the first parliament in May was a response to imperial pageantry and celebrity, rather than the creation of the Australian federation. The article suggests that Australians’ longstanding resistance to reform of the Federation is a legacy of their historic failure to attach to it.  相似文献   
115.
Despite a long history of legal challenges alleging that elections conducted at-large suppress minority representation, this remains the dominant electoral system in local governments throughout the United States. Moreover, a large empirical literature remains divided over the present-day impact of at-large elections on the political success of underrepresented groups. We reconcile the competing findings in this literature by providing contingent, causal estimates of the effect of conversion from at-large to ward elections on minority officeholding, using a novel identification strategy afforded by the California Voting Rights Act of 2001. We find a dramatic positive effect of conversion in districts where Latinos constitute a sufficiently large share of the voting population, and in large and residentially segregated districts. When these conditions are not satisfied, we consistently see null estimated effects.  相似文献   
116.
The purpose of this paper is to respond to gaps in our knowledge about patterns of female gang participation and its causes and consequences. Data from the Rochester Youth Development Study, a panel study that overrepresents adolescents at high risk for delinquency, are used to compare gang participation and delinquent involvement of female and male adolescents. We then examine the role of theoretical variables associated with both female and male gang membership. The results lead us to conclude that, for females as well as males, involvement in gangs is associated with substantially increased levels of delinquency and substance use. There is also some similarity in the factors associated with gang membership for both sexes, although lack of school success emerges as a factor of particular salience for female adolescents. The results suggest that theory and intervention need to address the phenomenon of female gang membership as an important component of urban youth problems.Authors' names are listed in alphabetical order.  相似文献   
117.
Policing in the inner-city neighborhood of Hyde Park is evaluated against a backdrop of racial polarization within the city of St. Louis and political pressures upon the St. Louis Metropolitan Police Department (SLMPD). Data garnered from immersion into Hyde Park community life, participation in and observation of numerous police/community meetings, document analyses, a focus group session with rank-and-file police officers, interviews with a sergeant and the captain of the Police Fifth District, and numerous informal conversations with residents and police officers provide evidence of poor community/police relationships. The data also provide evidence—on the part of police—of racial bias, lack of and/or poor understanding of the underlying causes of criminal behavior, pervading adventure and excitement lures toward police work, and a less than adequate understanding of the community oriented problemsolving (COPS) policing initiative. An underlying theme of little or absent informed locus of control at various levels regarding policing practices links issues of poor police/community relationships and the influence of racial bias and political pressures.  相似文献   
118.
He is author of many books and articles including Images of the American City; Professions, Work, and Careers; Psychiatric Ideologies and Institutions; Where Medicine Fails;and most recently Creating Sociological Awareness: Collective Images and Symbolic Representations;all published by Transaction. He and the co-authors have also written The Social Organization of Medical Work.  相似文献   
119.
120.
This article assesses the significance of Canada's role in the Opération des Nations Unies au Congo (ONUC) and, more generally, Canada's foreign policy during the early months of the Congo crisis. It argues that Prime Minister John Diefenbaker's government pursued a policy that recognized the importance of achieving Western objectives in the Congo but at the same time eschewed the strident Cold War views of some North Atlantic Treaty Organization (NATO) allies. The Canadian government was forced to weigh the importance of sometimes-conflicting foreign policy considerations when developing policy during the Congo crisis, and this ultimately lead to an unwillingness to be seen to be pursuing a concerted NATO approach to the Congo's tribulations. This would suggest recent interpretations that portray Canadian participation in ONUC as an example of how Canada's peacekeeping policy primarily served Western, Cold War objectives might not be entirely correct.  相似文献   
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