The GC/MS analysis of some commonly used non-steriodal anti-inflammatory drugs (NSAIDs) in pharmaceutical dosage forms and in urine

All the commonly used non-steriodal anti-inflammatory drugs (NSAIDs), except mefenamic acid, when extracted from the pharmaceutical dosage forms or the urines of users, and derivatized by silylation and then analysed by GC/MS, gave the mono- or the di-trimethylsilyl derivatives (depending on the number of derivatized groups in the drug) as the sole products. Mefenamic acid gave a mixture of products. When extracted from pharmaceutical dosage froms or from the urines of users, and analysed by GC/MS without derivatization, some of the NSAIDs were separated and detected as the unchanged molecules as the sole products, while others were separated and detected in altered forms as sole products or mixtures, depending on: (a) the solvent in which the extract was dissolved for injection into GC/MS, (b) the chemical structure of the drug, and (c) specifically for diflunisal, the presence or absence of potential methylating and/or acetylating agents on the GC column and/or septum. The main thermally-induced reactions of the underivatized NSAIDs included (i) methyl ester formation at the COOH group when the extract was dissolved in methanol, (ii) decarboxylation (i.e., loss of CO2), (iii) dehydration (i.e., loss of H2O) when the chemical structure permitted, such as for diclofenac, and (iv) cleavage at a carbon-heterocyclic nitrogen bond when one is present in an NSAID. Heating the urine in approximately 2 M HCl at 100 degrees C for 30 min, has been found to be a satisfactory means for effecting hydrolysis of the NSAIDs glucuronide conjugates. No metabolites, resulting from aromatic-ring hydroxylation, have been detected in urine for any of the NSAIDs studied.     

Hermeneutical Violence: Human Rights,Law, and the Constitution of a Global Identity

In this paper I want to analyze the process of denationalization of the law, to show how the globalization of the law can be considered as a new form of imperial control, but this time, labeled as acting for the welfare of its victims. In the first part I will analyze the national character of the law and show how it was used as an imperialistic instrument for the benefit of the imperial powers. In the second part I will show how the discourse of human rights and its universality has been the base to deny indigenous communities their right to define their own identity and how this discourse was used to destroy the old conception of sovereignty. The globalization of human rights implies the imposition of a western conception of rights, regardless of the contextual conception of the indigenous people. The discourse of human rights is part of a hermeneutical violence.     

Stay or exit: How do international nongovernmental organizations respond to institutional pressures under authoritarianism?

International nongovernmental organizations (INGOs) are increasingly important players in global politics and development. However, they are undergoing significant adaptations as governments worldwide have instituted restrictions to regulate their activities. What explains the various ways in which they respond to these institutional pressures? In our study of INGO responses to a new restrictive law in China, we identify four strategic responses with varying levels of compliance: legal registration, provisional strategy, localization, and exit. The institutional pressures—strategic responses link is influenced by INGOs' adaptive capacity, which is in turn shaped by an organization's issue sensitivity, value-add, government ties, and reputational authority. The integrated framework we develop for INGO strategic responses can shed light on state-INGO relations in other countries, many of which are subject to increasingly stringent regulations and a closing political environment.