The rise and rise of fentanyl in postmortem casework

Forensic toxicology laboratories are navigating a period of time with increasing drug overdose deaths, an opioid epidemic, the impact of the COVID-19 pandemic, and the illicit drug market flooded with novel psychoactive substances. In New York City, the Department of Forensic Toxicology has experienced a 56% increase in postmortem casework in the past decade with fentanyl detected in 80% of all overdose deaths. Over a period of 2.5 years, 15,638 postmortem cases were tested for the presence of fentanyl and fentanyl analogs using liquid-chromatography tandem mass spectrometry (LCMSMS). Fentanyl was detected in approximately one third of cases and of these 4447 cases with femoral blood. A twofold increase in cases with high concentrations of fentanyl (>100 ng/mL) was observed between 2021 and 2022. The minor metabolite and precursor chemical, 4-ANPP (4-anilino-N-phenethylpiperidine) may help differentiate between illicit and licit fentanyl. 4-ANPP blood concentrations were <10 ng/mL in 98% of the cases and the 4-ANPP:fentanyl ratio was <0.67 for 99.1% of blood specimens. Only six cases had 4-ANPP concentrations higher than the corresponding fentanyl blood concentration. This study also highlights, the changing fentanyl analogs found in postmortem cases since 2016 in NYC with the emergence of fluorofentanyl initially identified in 2020 and continuing to dominate in comparison with the prevalence of other analogs, many of which are no longer detected in casework. The detection of one of the latest drugs to be mixed with fentanyl, namely xylazine, has also increased in prevalence by 36.7% in 2022 compared with 2021.     

Ecological socialism and human needs∗

The proposed Sardar Sarovar Project (SSP) is the keystone of India's Narmada Valley Project, consisting of 30 large, 130 medium, and 3000 small dams. Backed by the Indian government and the World Bank (the tatter to the tune of $450 million in loans), the SSP has generated unprecedented opposition from farmers and others whose lands would be submerged by the project, as well as from many Indian environmentalists and environmental and human rights groups around the world. In 1990, under tremendous pressure, former World Bank President Barber Co noble called for the Bank to make an independent review of the project. The Team's Report of the Independent Review, which evaluated the resettlement and environmental impacts of the SSPt backed up the criticisms of the projecfs opponents. One of India's best known engineers, CNS Editorial Consultant KM. Datye, his associates, and other scientists working on sustainable development alternatives have produced a wealth of critical studies of large dam projects including the SSP project in India. Their conclusion is that there are technical alternatives to the project which better serve the interests of democratic control of water and energy resources, economic and social equity, and economic efficiency.     

Introduction to dalit poems

Abstract

The word dalit in Marathi, the language spoken by 50 million people in the state of Maharashtra in Western India, means “downtrodden,” “ground down,” or “depressed.” A caste-less word which ex-Untouchables have chosen for the new school of literature they have created, it includes all those who have suffered from the religio-social system. Short stories by ex-Untouchables began to appear in the 1950s, but the great swelling of creativity — poetry, novels, short stories, plays — appeared only in the late 1960s. The school is acknowledged by the Marathi literary establishment as a new and important development in the long history of Marathi literature. It represents a new voice, and its themes are protest, grievance, pride — and often revolution.     

A Biosemiotic Body of Law: The Neurobiology of Justice

We offer a theory regarding the symbolism of the human body in legal discourse. The theory blends legal theory, the neuroscience of empathy, and biosemiotics, a branch of semiotics that combines semiotics with theoretical biology. Our theory posits that this symbolism of the body is not solely a metaphor or semiotic sign of how law is cognitively structured in the mind. We propose that it also signifies neurobiological mechanisms of social emotion in the brain that are involved in the social and moral decision-making and behavior that law generally seeks to govern. Specifically, we hypothesize that the symbol of a collective human body in the language of law signifies neural mechanisms of pain empathy which generate a virtual, neurally simulated, emotional sense of sharing the feelings or pain of others and of thereby being one-in-body with or virtually equal to them. We speculate that this may be the neural basis of what is signified in legal and political theory as the “body politic” or “sense of equality,” because neuroscience and psychiatry further suggest that such pain empathy may provide the natural, emotional motivation to think and act in a rights-based manner. We conclude that misunderstanding of these neural mechanisms of pain empathy and related misinterpretation of this corporeal symbolism for the same may have long resulted in legal discourse that misinterprets the function of “pain” in the law and misinterprets the associated positive law, specifically the law regarding individual, equality-based rights and criminal justice, in particular, punishment theory.