Creatinine analysis in single collection urine specimens.

Controlled and uncontrolled fluid intake studies were conducted on series of volunteers over the 6 or 12 h of the study periods. Urine specimens were obtained from each subject randomly or at specified times relative to fluid ingestion. Creatinine analysis performed by a modification of the Abbott TDx procedure demonstrates that the values obtained from single collection specimens fall almost in the same range as the values from 24 h pooled collection specimens. The creatinine concentration can be used to indicate possible adulteration of urine specimens by dilution as a means of avoiding detection of use of drugs of abuse. Between 4 and 7 h are required for a decrease in creatinine concentration to about 100 mg/dL from an initial mean of about 170 mg/dL. A minimum of 6 h is needed for any creatinine value to fall to 50 mg/dL or less. Thus, it appears that creatinine output is sensitive to the amount of fluid ingested, but the relationship is neither linear nor immediate. The absence of a significant creatinine concentration in a specimen can be used as an indication of direct or indirect adulteration of the urine specimen by dilution or replacement with water. At NDSL-Great Lakes, a decline of the creatinine concentration to 30 mg/dL is used as a cutoff for differentiating between urine specimens that might have been tampered with to avoid detection of drug use and those specimens that are dilute for other reasons. Values at 10 mg/dL or less are suggestive of replacement by water. The information is provided to local commands for investigation prior to initiation of punitive action by the command.     

The Impact of Mediating Victim Offender Conflict: An Analysis of Programs in Three States

Abstract This article presents the findings of an analysis of victim offender mediation programs working with the juvenile courts in Albuquerque (NM), Minneapolis (MN) and Oakland (CA). The study is based upon 868 interviews with crime victims and offenders, including pre- and post-mediation interviews and two different comparison groups. The data that emerged from this study indicates that the vast majority of both victims and young offenders experience the mediation process and outcome (restitution agreement) as fair and are satisfied with the program. The mediation process used by the programs in Albuquerque, Minneapolis and Oakland results in greater satisfaction, greater perception of fairness and higher restitution completion rates than found in a matched sample of victims and offenders who were not referred to mediation.     

LSD Use as a barrier to public safety employment: A review of the medical findings

Conclusions In a review of available literature on the topic of adverse effects of the use of hallucinogenics, the authors found some remarkable evidence. First, there is not evidence that these drugs are physically or emotionally addictive. In fact, users generally discontinue use because of the impact of altering states of consciousness. Few have the desire to experience these effects beyond satisfying their curiosity about the drugs. There seem to be some specific personality factors that predispose individuals to experiment with psychedelic drugs, and certainly, specific personality types are prone to be associated with negative side effects in both the short and long-term. In light of the considerable amount of research which supports the premise that LSD is not as dangerous as once assumed, perhaps restrictive hiring policies should be reviewed and reevaluated in the case of the one-time user. If an individual passes all testing, and personal history shows stability, disqualifying a candidate for prior LSD use does not appear to be supportable by research finding. Again, this report is not meant to diminish the negative effect of hallucinogens on a small portion of our society. The intent is to point out that the medical literature does not support the contention that one-time hallucinogen use carries with it any undesirable long-term consequences. The importance of considering an individual within the context of testing and background can not be minimized.     

印度尼西亚经济展望

尽管国内政局动荡以及国外风云突变,印尼的通货膨胀问题仍得到遏制,利率正在下降,货币稳定.经济增长保持适中的速度,2004年上半年GDP增长了4.7%,主要是由于个人消费拉动GDP的增长,占增长总数的2/3.同时,由于竞选期延长,持续的不稳定因素使投资活动受到影响.虽然投资是GDP增长的第二大因素(占1/3左右),但印尼的投资形势仍不见有多大起色:投资额与GDP之比仍不够乐观,增长仅为18%,远远低于亚洲金融危机前的30%.     

A psychiatric study of persons charged with arson.

A total of 29 court-referred individuals charged with arson were psychiatrically studied. From this pre-trial cohort from a large heterogeneous urban population base, a higher rate of psychosis was found than in other recent studies. However, consistent with these studies was the rarity of the diagnosis of pyromania. An important finding of this study was the substantial number of fires set by individuals who are homeless mentally disordered or substance abusing, or both.     

References for determining the time of death by potassium in vitreous humor

The different statements concerning the slope and intercept of the regression line and the 95% limits of confidence are the reason that potassium in vitreous humor is not used (at least in Germany) as an aid in estimating the time of death. The relationship between the concentration of potassium and the time of death is mainly influenced by antemortem electrolyte imbalances caused by disease and/or duration of terminal episode. The influence of terminal episode is best identified by its duration (Adelson et al., J. Forensic Sci., 8 (1963) 503–514). In order to have a method suitable for every case and to be as precise as possible we looked therefore for parameters in vitreous humor which were stable postmortem and indicating antemortem electrolyte imbalance. Urea is such a parameter, being stable postmortem (Coe, Am. J. Clin. Pathol., 51 (1969) 741–750) and useful as a marker of antemortem electrolyte imbalance. Our investigations on potassium in vitreous humor, including sudden and hospital deaths after chronic lingering disease, revealed 95% limits of confidence of ±34 h up to 120 h postmortem. Reviewing only cases with urea less than 100 mg/dl the 95% limits of confidence could be reduced to ±22 h. Considering the duration of terminal episode (<6 h) the precision was ±20 h. In this way our modified procedure is suitable for every case with the resulting precision of estimation being determined only by the duration of the terminal episode and urea concentration.