Brain distribution of selected antipsychotics in schizophrenia

The brain distribution of phenothiazine antipsychotics in 22 confirmed schizophrenic and 11 control subjects were collected at autopsy. Specimens were homogenized, extracted with n-butyl chloride, and analyzed via liquid chromatography-mass spectrometry, using atmospheric pressure electrospray ionization operating in the positive mode. Drug concentrations normalized for those observed in cerebellum showed three distinct patterns of distribution corresponding to different structural features of each type of phenothiazine. Those drugs with high affinity for dopamine receptors were detected in the highest concentrations in regions with high concentrations of such receptors. However, those associated with relatively lower dopaminergic activity were found in the highest concentration in the occipital cortex, a region with a relatively low concentration of dopamine receptors. The regional brain distribution of thioridazine and its metabolites was concentration dependent. These results have implications for determining the role of these drugs in the sudden and unexpected deaths of schizophrenics.     

Duverger's Law, Penrose's Power Index and the Unity of the UK

As predicted by Duverger's Law, the UK has had two-party competition for long periods in most electoral districts. However, there are different patterns of two-party competition in different districts and more than two effective parties in the Commons. Since 1874, parliament has always contained parties wishing to modify the Union and contesting seats only outside England. By calculating the Penrose power index for all parties in the House of Commons for all general elections since 1874, we identify when such parties were pivotal. We explain various legislative changes (for example the Crofters Act 1886, the first three Irish Home Rule Bills, the Parliament Act 1911) and non-changes (for example the failure to enact female suffrage before 1914) by reference to the Penrose index scores. The scores also explain how and why policy towards Scotland, Wales and Northern Ireland changed and did not change in the 1970s.     

The reliability of digitized radiographs for dental identification: a Web-based study

In the era of Daubert and other judicial rulings pertaining to the acceptability of forensic evidence, it is increasingly important that experts are able to testify that their methods have been scientifically tested and that error rates and other factors relating to reliability have been published. The purpose of this study was to determine the reliability of digitized radiographic comparisons for the purposes of dental identification. Participants with various forensic backgrounds and experience levels were passively recruited to the website. Ten forensic identification cases composed of antemortem and postmortem dental radiographs were supplied to examiners using a bespoke website. Participants responded to the cases on two occasions after a one-month washout interval using the ABFO conclusion levels for forensic identifications. A total of 115 first attempts and 87 matched second attempts were received. Of the total responses, 72% were dentally trained respondents who had completed at least one forensic identification case; of these, 38% were experienced forensic dentists who had completed more than 25 identifications. Data relating to accuracy, intra- and inter-examiner agreement, and the effect of case difficulty are presented. Mean accuracy was 85.5% for all cases, with the experienced forensic dentists obtaining a 91% success rate. The inter-examiner agreement on the negative identification cases was classified as poor. The data suggest that dental identifications resulting from the comparison of postmortem and antemortem radiographs are valid, accurate, and reliable when undertaken by experienced odontologists.     

Regional politics: The European union and citizenship

This article examines the development of citizenship within the European Economic Community as a model for citizenship as such, within a global environment. In historical terms, citizenship evolved within the nation‐state, but the nation‐state, which is no longer valid as the exclusive model of economic development, may be inappropriate as a framework for social rights. The fluidity of labour within the European community means that traditional means of political representation within the nation‐state are irrelevant. Within a global context, the economic barriers which are required by nation‐states constitute political barriers to social rights through the vehicle of citizenship. The article considers the European experience of regional politics as lessons for citizenship reform in a global system.     

The Electoral Impact of Constituency Campaigning in Britain, 1992–2001

Political parties maintain local organisations and recruit members mainly to fight elections. For most of the post-war period, however, the dominant view among analysts has been that constituency campaigning in British general elections has little or no effect on election outcomes. This view has been challenged over the last ten years or so. Evidence derived from post-election surveys of constituency election agents following the 1992, 1997 and 2001 general elections is used here to show that the intensity of constituency campaigning significantly affects turnout levels and, for Labour and the Liberal Democrats, levels of party support. There is also some evidence that Conservative campaigning affected constituency variations in the party's performance in 2001. The conclusions reached on the basis of aggregate-level analysis are supported by analysis of individual-level data derived from British Election Study surveys. The effects of campaigning are not large, but they are clear and significant – and sufficient to affect the numbers of seats won by the major parties. In the light of this, parties have good reasons to maintain healthy local organisations.     

Technology transfer within China

This paper examines technology transfer within China. The Chinese government is currently placing great emphasis on developing indigenous scientific and technological capacity. In order to expedite the strengthening of science and technology capabilities, the government is promoting extraordinary measures designed to enhance the diffusion of technology within China. Special attention is focusing on strengthening the links between the academic, industrial, and defense sectors. In addition, the government is experimenting with policies commonly used in the West that encourage decentralization and the taking of local initiative. Although China's concern with technology transfer is very recent, it appears that the new technology transfer policies are having an immediate positive effect.     

Measuring community social organization: Sense of community as a mediator in social disorganization theory

The current study utilized an updated systemic model of social disorganization to investigate neighborhood effects on both positive and negative youth outcomes. Although empirical support for updated social disorganization models has increased in recent years, the field continues to rely too heavily on behavioral indicators of community social organization. Unfortunately, these measures do not assess the truly important social processes and dynamics that result in cohesive and supportive neighborhoods. It was proposed that sense of community (SOC) was a more valid, comprehensive, and applicable measure for the mediating variables in social disorganization theory. Results supported the hypothesis that SOC mediates the effect of neighborhood disadvantage on youth outcomes and implications for the field are discussed.