Postmortem Blood Concentrations of R‐ and S‐Enantiomers of Methadone and EDDP in Drug Users: Influence of Co‐Medication and P‐glycoprotein Genotype

Abstract: We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R‐ and S‐methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R‐enantiomer concentrations significantly exceeded that of the S‐enantiomers (Wilcoxon’s test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R‐methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P‐glycoprotein were associated with the concentrations of R‐ and S‐methadone and its metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine. No significant association was detected.     

Crime or social harm? A dialectical perspective

This paper proposes to examine some of the core philosophical issues to have arisen out of the recent calls to move “beyond criminology”. It will be claimed that the dismissal of crime as a “fictive event” is premature, as crime does indeed have an “ontological reality”. Nevertheless, it will be asserted that the relation between harm and crime is contingent rather than necessary. Accordingly, this paper will argue that there is merit to the claim that we should unify research on social harm through the creation of a new field, a step which would have the added benefit of constructing an alternative venue for crimes of the powerful scholars who wish to explore the destructive practices of states and corporations unconstrained. This paper, therefore, will also offer a dialectical definition of social harm based upon classical Marxist strains of ontological thought.     

Children's reporting patterns after witnessing homicidal violence – the effect of repeated experience and repeated interviews

For both legal and clinical purposes, it is of importance to study children's memories and reports of stressful events. The present study investigated the reporting patterns of 83 children who had witnessed homicidal violence, which is considered to be a highly stressful experience. More specifically, we explored the possible effects of prior violence exposure and of repeated questioning on the amount of details reported. Results showed that the majority of children provided detailed reports about the homicidal violence they had witnessed, including details concerning what happened before, during, and after the violent act. The children provided detailed and vivid testimonies from their experiences, whether they witnessed the event for the first time or had prior experience of witnessing severe violence against the victim by the perpetrator. Children with no prior experience of repeated violence who underwent repeated interviews provided more details than those interviewed once. The present data indicate that children are competent witnesses when questioned in legal contexts after having been exposed to extremely stressful events. These findings have implications for research related to children's memories and reporting of traumatic experiences, as well as practical implications for future treatment and evaluation of children's testimonies.     

Recall of unpleasant emotion using memory-enhancing principles

Abstract

Two experiments are presented to examine the issue of memory for past emotions. Participants rated their emotional reactions on the occasion of watching a film, and in a subsequent session, they were asked to recall and rate the emotion as experienced when viewing it. In the first experiment, participants underestimated unpleasant emotion at recall, but their recall was improved with the presentation of a visual cue pertaining to the emotion-inducing film event. In the second experiment, participants were assisted in probing perceptual aspects of the event by means of memory-enhancing instructions underlying the Cognitive Interview. These participants consistently recalled emotional intensity, as compared to participants in the unassisted recall condition who underestimated prior emotion. This research suggests that ratings of prior emotion are easily influenced by features of the retrieval context, and that consistent recall may be achieved by memory-enhancing principles of the Cognitive Interview.     

Strategic Horizons: Futures Forecasting and the British Intelligence Community

The article deals with the role and benefit added by the use of horizon scanning in intelligence analysis in the UK. It asserts that horizon scanning as a technique, while not entirely akin to the tradecraft of intelligence analysis, has much to contribute to its success. Specifically, is asserts that a horizon scanning function in the JIO and the Cabinet Office should be made permanent, as bureaucratic tumult in the wake of the 2010 SDSR have left the capability un-staffed, though still established. Within the UK intelligence community, such an organization may have positive roles to play in the processes of challenge, the setting of collection priorities, and overall long-term UK intelligence assessment at the national level.     

Measures for mines: approaches to impact assessment in humanitarian mine action

The ability to assess the impact of humanitarian interventions is key both for priority-setting and for maximising the quality of projects. Humanitarian mine action (hma) is a young sector, where the application of impact assessment is still in its infancy. In this article we will briefly revisit the history of impact assessment in hma, before reviewing the strengths and weaknesses of three different impact-assessment approaches: 1) the Landmine Impact Survey; 2) economic analysis; and 3) community studies. Each of the approaches has its own merits as well as its own shortcomings and the selection of one approach, or several approaches combined, needs to be informed by the particular conditions in a given setting. We argue that hma should always be based on sound impact-assessment practices, but also that it is important to encourage a general understanding of broader impact issues—as opposed to narrow output definitions—among all relevant stakeholders. In spite of considerable progress over the past few years on this issue, impact in mine action is still largely perceived as an event rather than an integral part of the process and specialised units responsible for impact assessment isolate this activity from day-to-day field management.     

Participatory development and empowerment: The dangers of localism

Recent discussions in development have moved away from holistic theorisation towards more localised, empirical and inductive approaches. In development practice there has been a parallel move towards local ‘participation’ and ‘empowerment’, which has produced, albeit with very different agendas, a high level of agreement between actors and institutions of the ‘new’ Left and the ‘new’ Right. This paper examines the manifestations of this move in four key political arenas: decentralised service delivery, participatory development, social capital formation and local development, and collective actions for ‘radical democracy’. We argue that, by focusing so heavily on ‘the local’, the see manifestations tend to underplay both local inequalities and power relations as well as national and transnational economic and political forces. Following from this, we advocate a stronger emphasis on the politics of the local, ie on the political use of ‘the local’ by hegemonic and counter-hegemonic interests.     

War by other means: the ltte's strategy of institutionalising power sharing in the context of transition from war to peace—a response to Muttukrishna Sarvananthan

Abstract

This paper analyses the Indian government's policy response to the Trade-related Intellectual Property Rights Agreement (trips) and examines the implications of this response for food security and farmers. trips has become one of the most controversial agreements of the wto. This is because of its wide and far-reaching mandate and its complex socioeconomic implications. It is argued that the changes made to the Indian Patents Act in response to trips will compromise the food sector and the rights of small farmers by conferring strong rights on upstream agents who produce proprietary agricultural inputs using biotechnology. Not only are these agents able to exert monopoly price control over agricultural inputs for 20 years, they also have the right to determine the conditions under which farmers and researchers use patented processes and products. The paper outlines policy options available to the Indian government to tighten the scope of patentability in the food sector.