Quantitation of Synthetic Cannabinoids in Plant Materials Using High Performance Liquid Chromatography with UV Detection (Validated Method)

Plant based products laced with synthetic cannabinoids have become popular substances of abuse over the last decade. Quantitative analysis for synthetic cannabinoid content in the laced materials is necessary for health hazard assessments addressing overall exposure and toxicity when the products are smoked. A validated, broadly applicable HPLC‐UV method for the determination of synthetic cannabinoids in plant materials is presented, using acetonitrile extraction and separation on a commercial phenylhexyl stationary phase. UV detection provides excellent sensitivity with limits of quantitation (LOQs) less than 10 μg/g for many cannabinoids. The method was validated for several structural classes (dibenzopyrans, cyclohexylphenols, naphthoylindoles, benzoylindoles, phenylacetylindoles, tetramethylcyclopropylindoles) based on spike recovery experiments in multiple plant materials over a wide cannabinoid contents range (0.1–81 mg/g). Average recovery across 32 cannabinoids was 94% for marshmallow leaf, 95% for damiana leaf, and 92% for mullein leaf. The method was applied to a series of case‐related products with determined amounts ranging from 0.2 to >100 mg/g.     

Using Game of Thrones to Teach International Relations

Despite the known benefits of long-term, game-based simulations they remain underutilized in Political Science classrooms. Simulations used are typically designed to reinforce a concept and are short-lived, lasting one or two class sessions; rarely are entire courses designed around a single simulation. Creating real-world conditions in which students operate often requires the development of distinct cultures and shared experiences that only long-term interactions can generate. These long-term interactions create a community where the past interactions of players matter when making decisions about future action. Long-term role-playing also gives students a forum to fully immerse themselves in the material resulting in deeper content comprehension. This article presents a framework for using a long-term, game-based simulation based on the popular television show Game of Thrones. The simulation uses an active learning approach to help students understand a variety of topics related to International Relations and related fields. The article concludes with a discussion on how the simulation can be modified to fit a variety of non-Political Science courses as well as provides the framework for an experimental design to test the effectiveness of the simulation.     

The Neurobiology of Fairness and Social Justice: An Introduction

The study of social justice has always been an interdisciplinary undertaking, but in recent years neurobiologists have joined scholars and scientists from other areas to tackle complex questions concerning fairness, empathy, equality, hierarchy, and ideological conflict and polarization. By synthesizing insights from multiple, mutually informative levels of analysis, it is possible to shed new light on basic biological processes that reflect, inspire, and inhibit the pursuit of a more just society. With this special issue we highlight groundbreaking research on the neurobiology of fairness and social justice, bringing together six articles that address core themes of social justice, including individual variability in definitions of fairness, the genetic basis of economic egalitarianism, neural bases of empathy in environmental and intergroup domains, and the neural and genetic correlates of ideological polarization. Taken in conjunction, these diverse contributions bring multiple theoretical perspectives and research methods to bear on the shared goal of understanding and promoting social justice.     

Exploring the Intersection of Theory and Practice of Arts for Peacebuilding

A rising number of public and nongovernmental organisation (NGO) leaders are employing the arts in efforts aimed at encouraging social change. Meanwhile, scholars have offered a number of theories concerning the character of political agency and its exercise, and contended that effective use of the arts may result in individual and group epistemic change. Far fewer analysts, however, have married such theorisations of aesthetics with empirical investigations of how professionals actually use the arts to promote such shifts. This article addresses this concern by studying the strategies adopted by two international nongovernmental organisations (INGOs), American Voices and Bond Street Theatre, that have worked to encourage peace through music and theatre-making in light of changing conceptions of agency and the power of aesthetics to stimulate its exercise. We outline the approaches these NGOs adopt to do so and the mechanisms by which their leaders believe their work catalyses changes in values at the individual and community levels. We argue that understanding these dynamics more thoroughly and in light of conceptions of agency and aesthetics leads to a stronger theorisation of whether and how arts-based peacebuilding efforts can lead to sustainable community cultural change.     

Michael Harris, <Emphasis Type="Italic">Mathematics without Apologies: Portrait of a Problematic Vocation (Science Essentials)</Emphasis>

This is a review of mathematician Michael Harris’s book “Mathematics without Apologies: Portrait of a Problematic Vocation.”