Immunohistochemical investigation of pulmonary surfactant-associated protein A in fatal poisoning

To evaluate the immunohistochemical distribution of pulmonary surfactant-associated protein A (SP-A) in fatal poisoning in relation to the effects of drugs and poisons on respiratory function, 42 forensic autopsy cases were examined by scoring the staining intensity. The highest scores of SP-A staining, with dense granular deposits (aggregates) in the intra-alveolar space, were observed in fatalities from pancuronium bromide (muscle relaxant) injection and petroleum (butane) gas inhalation. Poisoning with organophosphate pesticides and arsenic (ingestion) showed a second grade SP-A score. However, The SP-A scores were relatively low in ethanol and sedative-hypnotic intoxication. Carbon monoxide intoxication showed a varied degree of SP-A score, and the aggregated SP-A score tended to be higher in cases of lower blood carboxyhemoglobin concentration. A varied SP-A score was also observed in methamphetamine fatalities, in which the score was relatively low in cases with a higher serum drug level. Increase of SP-A was not always associated with the intra-alveolar effusion or hemorrhages. The above-described observations suggested that the immunohistochemical score of SP-A may be a possible indication for intensity and duration of drug/poison-dependent respiratory distress.     

A biomechanical reconstruction of a wound caused by a glass shard--a case report

During the course of a criminal trial, an investigating pathologist is commonly asked how much force was required to produce an injury. This subjective opinion is based on the pathologist's previous experience of dealing with wounds inflicted with similar weapons. However, in the case of stab wounds inflicted by broken glass, it is unlikely that two glass fragments would be physically similar. In the case studied, two theories were examined: that a wound resulted from a thrown glass fragment or that it had been caused as a stab injury by the glass held in the bare hand. The investigation involved quantifying the energy required for human tissue penetration, comparison of sharpness, a biomechanical analysis of throwing actions and testing of the hypothesis that if the glass shard were used as a stabbing implement it would result in a cut to the hand.The investigation utilised a scientific methodology that reduced the need for speculative (though informed) opinion from the pathologist by producing quantitative results.     

Classification of prepaid cards based on multivariate treatment of data obtained by X-ray fluorescence analysis

Two hundred prepaid cards, which had been used in Nagoya-city's subway in Japan, and another 32 prepaid cards (11 were real turnpike cards, 20 were counterfeit cards and 1 was a white card) were evaluated by X-ray fluorescence (XRF) without any pre-treatment. A preliminary investigation was performed on 200 prepaid cards in order to find an identification method for the turnpike cards. By plotting the relative intensity of titanium versus that of iron obtained by XRF, the cards were clearly classified into seven groups. On the other hand, the cards could be divided into four groups by a multivariate analysis using the relative intensities of five elements such as chlorine, calcium or tin, titanium, iron and barium. Using these results to classify the Japanese turnpike cards, they were divided into three groups or two groups. One of three groups or two groups was the counterfeit card group.     

7-Locus Y chromosome haplotype profiling in a northern Spain population.

Allele and haplotype frequencies for 7 Y-specific STR loci (DYS19, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393) had been determined in a sample of 107 unrelated males living in Cantabria, a region in northern Spain, by means of two multiplex PCRs.     

A study in relation to the random distribution of four fibre types on clothing (incorporating a review of previous target fibre studies).

A new target fibre study was undertaken building upon eight previous published studies, which are reviewed here. Fifty-eight items of outer clothing, obtained from households across England, were taped and searched for three types of commonly occurring fibres and one less common fibre type. The tapes were examined using a combination of automatic and manual searching. Any fibres similar to the target fibres were removed and examined using microspectrophotometry, comparison microscopy, thin layer chromatography (TLC) and fourier transform infrared spectroscopy (FTIR) where applicable. One polyester fibre, four acrylic fibres and eleven wool fibres were found that matched the three commonly occurring target fibre samples. None of the less common polyester fibres were found. One item had six matching wool fibres and another had the polyester fibre and an acrylic fibre recovered from it. The remaining eight fibres were each recovered from individual items. The results suggest that finding a large number of fibres that match a control is unlikely to happen by chance, which supports the findings of the previous target fibre studies.     

Risky Firearms Behavior in Low-Income Families of Elementary School Children: The Impact of Poverty, Fear of Crime, and Crime Victimization on Keeping and Storing Firearms

This report examines possession and storage of firearms in low-income urban families with at least one child between 8 and 12 years of age. The data primarily consisted of responses to a survey administered to parents, but these data were supplemented by records obtained from discussion groups composed of children between 8 and 12 years of age. The data were collected from five low-income neighborhoods in a medium sized city in the Pacific Northwest as part of a larger study focusing on the presence of risk factors for substance abuse, violence, and gang activity. All five neighborhoods are known to be plagued by poverty, violence, substance abuse, and gang activity. To make our findings more understandable, we compared our findings from these neighborhoods to similar data from a middle-class neighborhood. Middle-class parents were twice as likely to have firearms in their homes, but were much less likely to keep them loaded and/or unlocked. High rates of victimization, fear of crime, self-protective behavior, and exposure to threats or attacks were associated with keeping firearms for protection and engaging in risky gun behavior in the home.     

Diagnosis of a captive-bolt injury in a skull extremely destroyed by fire

The authors report on a combined suicide of a 71-year-old farmer who fired a shot to his forehead with a livestock stunner before burning himself. As the fire was fueled by a pile of firewood it burnt for many hours, thus, causing subtotal incineration of the body. The remaining bones were calcined and reduced to a residual mass of only 3 kg. In spite of the extreme destruction, a circular bone defect corresponding to the site where the captive-bolt had entered the skull could be identified in the frontal squama. The example of this suicide is used to illustrate the problems of distinguishing between mechanical and thermal fractures. As expected, the attempted isolation and amplification of both nuclear and mitochondrial DNA for the purpose of identification was not successful.     

Correlation between saw blade width and kerf width

Most studies of saw marks have focused on morphological characteristics and their utility in identifying saws suspected to have been utilized in cases of criminal dismemberment. The present study examined the extent to which metric analysis may be used to correlate saw blade measurements with minimum kerf widths (MKWs). A sample of 56 partially defleshed white‐tailed deer (Odocoileus virginianus) long bones was utilized as proxy for human remains. The long bones were cut using a variety of commercially available saws, including 11 manual‐powered and 5 mechanical‐powered saws. A total of 496 false start kerfs (FSKs) were created. Two experiments were performed, with the first test examining the MKWs of FSKs produced on specimens that were restrained using a bench vise, while the second test analyzed the MKWs of FSKs produced on minimally restrained specimens. Statistical analysis using Hierarchical Linear Modeling (HLM) indicated a positive relationship between saw blade width (mm) and MKW, with blade width (p < 0.001) and the overall difference between the mechanical‐ and manual‐powered saws (p = 0.029) tested, reaching statistical significance. A comparison of MKWs produced using manual‐powered saws on restrained and minimally restrained bones suggests that restraint condition (p = 0.009) has a statistically significant effect. In comparisons of MKWs to blade widths, the average ratio for mechanical‐powered saws is 18.7% greater than the average ratio for manual‐powered saws. While the mode of the ratios was 1.42, thus supporting the general rule that MKW does not exceed 1.5 times blade width, multiple individual ratios did surpass 1.5.     

Japanese political studies: where are we? How did we get here? Where are we going?

Abstract

We offer a historically grounded analysis of major works in the study of Japanese politics with a focus on the period since the Second World War. The article traces an evolution from early assessments of Japanese democracy and modernization through the focus on the political economy of high growth to the current disciplinary-based emphasis on narrower but more empirically defensible research. We close with a call for future research to take greater risks at synthetic analyses of Japanese politics broadly considered.     

The importance of policy design fit for effectiveness: a qualitative comparative analysis of policy integration in regional transport planning

Policy Sciences - Policy design has returned as a central topic in public policy research. An important area of policy design study deals with effectively attaining desired policy outcomes by...