Closing the distance between academia and market: experimentation and user entrepreneurial processes

We inductively examine how exceptional Principal Investigators (PIs), who are active in biotechnology, medical devices, and nanotechnology, affect new technology trajectories and shape market boundaries by leveraging synergies stemming from their being simultaneously a scientist and a (lead) user. Our central contribution is the scientist-user template that explores how these types of PIs perform successfully their technology transfer task and, consequently, address increasing expectations about PIs as agents of economic and societal development. Building upon five illustrative case histories, we propose that scientist-user PIs exhibit superior capabilities in turning generic technology into several selected market applications, with no negative effects on their academic role. Overall, we develop a holistic view of synergies stemming from the scientist and user sides and offer insights into academic entrepreneurship and research project management.     

Microcrystal analysis of cocaine hydrochloride and added adulterants

The objective of this project was to investigate the trends of changes in the crystal morphology of cocaine in the presence of the common adulterants, caffeine and lidocaine HCl. By performing gold chloride microcrystal tests on samples of cocaine with adulterants at 10, 20, and 50% concentrations, trends in the changes of the crystal morphology can be linked to specific adulterants and concentrations. For cocaine/caffeine mixtures, the trend is elongation of one axis, additional branching, and brown discoloration of the crystals. At 50:50 cocaine/caffeine mixtures, branched spherical crystals and long needles appear. The trends for cocaine/lidocaine mixtures include elongation of one axis with an X-shaped middle axis. The axes continue to grow and branching decreases until at 50%, spherical clusters of needles appear. These results indicate microcrystal analysis can be used as a novel method for presumptively identifying not only cocaine but also the identity and concentration of the adulterant.