Headspace solid-phase microextraction (HS-SPME) and liquid-liquid extraction (LLE): comparison of the performance in classification of ecstasy tablets. Part 2

Headspace solid-phase microextraction (HS-SPME) is assessed as an alternative to liquid-liquid extraction (LLE) currently used for 3,4-methylenedioxymethampethamine (MDMA) profiling. Both methods were compared evaluating their performance in discriminating and classifying samples. For this purpose 62 different seizures were analysed using both extraction techniques followed by gas chromatography-mass spectroscopy (GC-MS). A previously validated method provided data for HS-SPME, whereas LLE data were collected applying a harmonized methodology developed and used in the European project CHAMP. After suitable pre-treatment, similarities between sample pairs were studied using the Pearson correlation. Both methods enable to distinguish between samples coming from the same pre-tabletting batches and samples coming from different pre-tabletting batches. This finding emphasizes the use of HS-SPME as an effective alternative to LLE, with additional advantages such as sample preparation and a solvent-free process.     

Gasoline on hands: preliminary study on collection and persistence

The identification of an arsonist remains one of the most difficult challenges a fire investigation has to face. Seeking and detection of traces of gasoline could provide a valuable information to link a suspect with an arson scene where gasoline was used to set-up the fire. In this perspective, a first study was undertaken to evaluate a simple, fast and efficient method for collecting gasoline from hands, and to assess its persistence over time. Four collection means were tested: PVC, PE and Latex gloves, as well as humidified filter paper. A statistical assessment of the results indicates that Latex and PVC gloves worn for about 20 min, as well as paper filter rubbed on hands, allow an efficient collection of gasoline applied to hands. Due to ease of manipulation and to a reduced amount of volatile compounds detected from the matrix, PVC gloves were selected for the second set of experiments. The evaluation of the persistence of gasoline on hands was then carried out using two initial quantities (500 and 1000 microl). Collection was made with PVC gloves after 0, 30 min, 1, 2 and 4h, on different volunteers. The results show a common tendency of massive evaporation of gasoline during the first 30 min: a continued but non-linear decrease was observed along different time intervals. The results of this preliminary study are in agreement with other previous researches conducted on the detection of flammable liquid residues on clothes, shoes and skin.     

Non-Muslim citizens as foreigners within: how Ecnebi became Yabancı from the Ottoman Empire to the Turkish Republic

Since the establishment of the Republic in 1923, any non-Muslim born in Turkey, whatever his/her religion, is a Turkish citizen as are any of his/her Muslim fellows. However, sometimes he/she might consider him/herself an alien and might even be regarded as such by the official authorities. The purpose of this article is to shed light on this reality from an historical perspective. Based on the comparison of two terms (ecnebi and yabanc?, both meaning foreigner) that had become frequently used during the last Ottoman decades, the analysis establishes to what degree ecnebi was replaced by yabanc? in official republic terminology. The article argues that this change might be related to the formation of less visible categories of foreigners that partly originated from the confessional imperial framework based on the differentiation between Muslims and non-Muslims. Far from being set aside as the Kemalists have long claimed, this framework has prevailed. It partly explains to what extent, as a result, in the history of the Turkish Republic, non-Muslim Turkish citizens have sometimes been regarded as ‘foreigners within’ (içerdeki yabanc?).     

An Unusual Case of Death Probably Triggered by the Association of Buprenorphine at Therapeutic Dose with Ethanol and Benzodiazepines and with Very Low Norbuprenorphine Level

Buprenorphine is largely prescribed for maintenance treatment in opioid dependence due to its safety profile. Nevertheless, fatalities at therapeutic dose have been described when associated with other central nervous system depressants, such as ethanol or benzodiazepines. Here, we report a case of death due to association of buprenorphine at therapeutic dose with benzodiazepines and ethanol. Although toxicity has been often attributed to its metabolite norbuprenorphine rather than to buprenorphine itself, in our case, norbuprenorphine was not detected in urine and bile and only in traces in blood. Moreover, the presence in blood of free buprenorphine but not of glucuronide metabolites argues for an unusual early death, at the beginning of buprenorphine metabolism. We propose that in the context of prior toxic impregnation, buprenorphine directly (and not via its metabolite norbuprenorphine) acted as a triggering factor by blocking the ventilatory response, rapidly leading to fatal respiratory depression.     

The Controversies Over the Customary Prohibition on the Use of Force: A Methodological Debate

Controversies about the rule prohibiting the use of force havemainly focused on issues such as the conditions for self-defenceor the existence of a right to humanitarian intervention. Beyondthe question of the validity or relevance of each substantialargument, a comprehensive analysis of the doctrine reveals thatthe debate is actually more about methodology than substance.Hence, those who stand for an enlarged conception of the rightto self-defence or who support a right of humanitarian interventiontend to adopt a particularly loose method in defining the contentof the customary rule.     

Commission's Action Plan to combat counterfeiting and piracy: right-holders, help yourself, and the Commission will help you!

The European Commission's Directorate General Taxation and CustomsUnion (DG TAXUD), in charge of the monitoring of border measuresunder Regulation 1383/2003, invited right-holders and otherinterested parties to an informal meeting in Brussels on 24February 2006.     

Extensive Necrotic Purpura in Levamisole‐Adulterated Cocaine Abuse – A Case Report

Levamisole, which is used as an adulterated compound of cocaine, is currently being seen year after year in cocaine intoxication. For a few cases in the last decade, necrotic purpura and neutropenia after levamisole/cocaine intoxication have been described in the medical community. Herein, we present an original case of levamisole intoxication of a 40‐year‐old woman who smoked heroin and cocaine few during a month. She rapidly presented an extensive necrotic purpura of the nose, cheeks and extremities (lower and upper), and immunologic reactions (positive anti‐MPO and anti‐HNE). Levamisole was detected on hairs with ultra‐high performance liquid chromatography and tandem mass spectrometry. The case reports also a probable cocaine supplier deceit, which bring pure drug for hospital investigation after the intoxication of his client. The intoxicated woman had survived with several skin and chronic pain complications. That case recalls the knowledge about levamisole with a short review of the forensic literature.     

Father–child relations in France: Changes in paternal authority in the nineteenth and twentieth centuries

The history of fathers is one of the most suggestive lines of inquiry for understanding adolescents. The power of a father over his children, whether minors or those that had reached their majority, is a simple power, but one that became more complicated. The article assembles the elements needed to illustrate major trends in the long history of paternity. The adoption of the Civil Code in 1804 marked the triumph of a patriarchal system. More than 150 years later, the law of January 4, 1970 abolished paternal authority and replaced it with parental authority. Now, the father could only share parental authority with the mother on the strict condition that he is legally married to her. This seems like a linear movement, but it should be noted that it follows an earlier similar shift.