Determination of cocaine and benzoylecgonine in human amniotic fluid using high flow solid-phase extraction columns and HPLC.

A new solid-phase extraction procedure for the determination of cocaine and benzoylecgonine in amniotic fluid, using high flow co-polymeric sorbents is reported. The recoveries of cocaine and benzoylecgonine within the range 0.1-1 mg/l were 95.7% and 50.3%, respectively. The use of high-flow sorbents allowed the easy extraction of amniotic fluid regardless of sample viscosity or physical nature. The use of these solid-phase columns provided many advantages over the more commonly used solvent extraction, including an increase in extraction speed and efficiency, reduced operator time, reduced solvent use and disposal volumes and exceptional extract quality. Further, the determination of amniotic fluid obtained from pregnant cocaine users may provide important information about handling of cocaine by the fetus at various gestational ages. The procedure was successfully applied to amniotic fluid from suspected cocaine abusers.     

The Patents Court's streamlined litigation procedure--two years on

Legal and practical context. The streamlined procedure is asimplified patent litigation procedure that was introduced overtwo years ago in the English Patents Court and Patents CountyCourt. This article looks at the procedure, the way it has beenapplied since its introduction and the effect it has had onpatent litigation in the UK. Key points. The procedure was designed to deal with simple patentcases quickly and relatively cheaply. It is geared towards aone day trial taking place approximately eight months afterthe commencement of proceedings. Under the procedure there isno automatic disclosure, no experiments and cross-examinationis limited to permitted topics only. Although it was designedwith patents in mind, the procedure is available for all appropriateactions heard in the Patents Court and Patents County Court.It is only suitable, however, for relatively simple actionsin which complex findings of fact are not necessary. Conclusions. Not many actions have come to trial under thisprocedure, but its availability is nonetheless of great significanceto patent litigation in the UK. This is because it providesa new point of departure for directions in certain types ofaction and because its availability has increased access topatent litigation in the UK and has renewed interest in thePatents Court and Patents County Court as forums in which toissue patent proceedings.