Parent–Child Relations and Offending During Young Adulthood

There is a long tradition of studying parent–child relationships and adolescent delinquency. However, the association between parent–child relationships and criminal offending during young adulthood is less well understood. Although the developmental tasks of young adulthood tend to focus on intimate relationships, employment, and family formation, the parent–child bond persists over the life course and likely continues to inform and shape behavior beyond adolescence. Using data from the Toledo Adolescent Relationships Study (TARS), the influence of parental involvement on patterns of offending among respondents interviewed first as adolescents (mean age of 15 years), and later as young adults (mean age of 20 years), is examined. The TARS sample used for our study (N = 1,007) is demographically diverse (49.5% female; 25.3% Black; 7.2% Hispanic) and includes youth beyond those enrolled in college. The influences of both early and later parenting factors such as support, monitoring and conflict on young adults’ criminal behavior are examined. Results show that early monitoring and ongoing parental support are associated with lower offending in young adulthood. These effects persist net of peer influence and adolescent delinquency. This suggests the importance of examining multiple ways in which parental resources and support influence early adult behavior and well-being.     

Acetyl Fentanyl: Trends and Concentrations in Metro Detroit

Acetyl fentanyl (N‐[1‐phenethylpiperidin‐4‐yl]‐N‐phenylacetamide) is a potent opioid analgesic with no medicinal uses. We report deaths between 2016 and 2017 at the Medical Examiner's Office in Detroit, MI where acetyl fentanyl was found in the decedent's blood and compare them to previously published deaths between 2015 and 2016. The recent cases (cohort B) had a mean acetyl fentanyl concentration of 0.9 ng/mL (range: 0.1–5.3 ng/mL) and an associated higher concentration of fentanyl along with multiple other drugs present. The older cases (cohort A) had higher concentrations of acetyl fentanyl (mean: 8.9 ng/mL; range: 0.28–37 ng/mL) with lower, yet still toxic, concentrations of fentanyl. We conclude that the cause of death in these recent cases was likely multiple drug toxicity with fentanyl and that the consistently observed lower peripheral blood concentrations of acetyl fentanyl are most likely an artifact in the manufacture of the consumed illicit fentanyl.     

MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification

The expression of the human micro-opiate receptor (MOR1) in post mortem human brain tissue was examined using real-time PCR technology. Tissue samples from 11 fatalities due to opiate overdose and five normal subjects with different causes of death were analysed in order to elucidate whether chronic opiate abuse is followed by a regulation of MOR1 expression. In each case nine selected brain regions (thalamus, caudate nucleus, hypothalamus, ventral tegmentum, hippocampus, amygdala, frontal cortex, nucleus accumbens, putamen) were evaluated. The MOR1-mRNA level was determined relative to the housekeeping gene beta2-microglobulin. While in most regions the MOR mRNA levels in the brain of addicts were not different from the control group-with varying levels between 0 and 15% of housekeeping gene level-in the brains of three drug-related fatalities an enormous increase was encountered in the thalamus where the MOR-mRNA level amounted for up to 10,000% of the measured housekeeping gene level. The results obtained by toxicological hair analysis in the group of drug-related fatalities indicate that the enormous thalamic MOR1-expression is primarily found in individuals who died from acute heroin overdose but did not show signs of a substantial chronic administration of the drug. Further studies have to be performed to evaluate if the observed MOR1-mRNA up-regulation in the thalamus in a subpopulation of acute lethal intoxications mirrors a state of functional hypersensitivity associated with the occurrence of death.     

The effect of oleoresin capsicum "pepper" spray inhalation on respiratory function

We performed a randomized, cross-over controlled trial to assess the effect of Oleoresin capsicum (OC) spray inhalation on respiratory function by itself and combined with restraint. Thirty-five subjects were exposed to OC or placebo spray, followed by 10 min of sitting or prone maximal restraint position (PMRP). Spirometry, oximetry, and end-tidal CO2 levels were collected at baseline and throughout the 10 min. Data were compared between groups (ANOVA) and with predefined normal values. In the sitting position, OC did not result in any significant changes in mean percent predicted forced vital capacity (%predFVC), percent predicted forced expiratory volume in 1 s (%predFEV1), oxygen, or CO2 levels. In PMRP, mean %predFVC and %predFEV1 fell 14.4 and 16.5% for placebo and 16.2 and 19.1% for OC, but were not significantly different by exposure. There was no evidence of hypoxemia or hypercapnia in either groups. OC exposure did not result in abnormal spirometry, hypoxemia, or hypoventilation when compared to placebo in either sitting or PMRP.     

Cyanide fatalities: case studies of four suicides and one homicide

Deaths due to cyanide poisoning are relatively rare, largely owing to the restricted availability of cyanide. Nevertheless, the authors report five cases of cyanide fatalities occurring within a few months. Cyanide is one of the most rapidly acting poisons known and is still used for suicide and homicide. The discussion focuses on the circumstances, metabolic changes, pathophysiology, blood levels, diagnosis, and management of cyanide poisoning.     

Psychosocial antecedents of unwed motherhood among indigent adolescents

Theoretically based hypotheses regarding psychosocial antecedents of unwed motherhood among indigent adolescents are tested. Data regarding psychosocial antecedents were obtained from a survey of a 50% sample of seventhgraders in a large urban school system. Hypotheses were tested by comparing three groups of subjects from among these respondents: (1) 82 female adolescents who received perinatal care at an adult development clinic for indigent adolescents (all gave birth out of wedlock at least one year following the baseline survey and prior to their eighteenth birthday); (2) 164 matched (by race, mother's education, and school) controls — two matches for each pre-unwed mother; and (3) 164 randomly selected controls — two controls for each preunwed mother. The results were consistent with the assertion that deviant behaviors related to and including unwed motherhood are alternative deviant responses to the subjectively recognized inability to defend against self-rejection in the course of membership group experiences in anticipation of self-enhancing consequences of the deviant behaviors. The positions in the social structure occupied by the pre-unwed mothers predispose the subjects to deviant responses by (1) increasing the probability of self-devaluing experiences and the subjective association of these experiences with the normative structure and (2) offering highly visible deviant alternatives that offer greater self-enhancing potential than the perceived low self-enhancing potential of the normative environment. The deviant patterns to which the subjects are predisposed are in fact adopted when prior social controls effictively exercised by parental and school authorities erode (as a result of the subject's identification of family and school as persistent sources of self-devaluing experiences). The specific modes of deviance adopted, including patterns associated with unwed motherhood outcomes, are apparently consistent with subculturally influenced values and adaptive/coping/defensive patterns. The total pattern of findings suggests that the same general theory of deviant behavior that has been applied to other modes of deviance is appropriate in understanding precursors of unwed motherhood among indigent adolescents.Received his Ph.D. in sociology from New York University in 1958. Current research interests are social psychiatry and, more specifically, the reciprocal relationship between self-attitudes and the adoption of deviant response patterns.Received her Ph.D. in educational psychology from University of Texas at Austin. Main interest is adult development.Received his M. D. from University of Texas Medical Branch in Galveston. Research interests are self-destructive behavior and alcoholism.