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101.
Validation of new methods 总被引:8,自引:0,他引:8
Reliable analytical data are a prerequisite for correct interpretation of toxicological findings in the evaluation of scientific studies, as well as in daily routine work. Unreliable analytical data might not only be contested in court, but could also lead to unjustified legal consequences for the defendant or to wrong treatment of the patient. Therefore, new analytical methods to be used in forensic and/or clinical toxicology require careful method development and thorough validation of the final method. This is especially true in the context of quality management and accreditation, which have become matters of increasing relevance in analytical toxicology in recent years. In this paper, important considerations in analytical method validation will be discussed which may be used as guidance by scientists wishing to develop and validate analytical methods. 相似文献
102.
Women who experience recurrent intimate partner violence (IPV) may use alcohol or drugs because they expect that these substances will help them cope with the negative physical and psychological sequelae of IPV. However, expectancies for alcohol and drug use have not been explored among this population of women. We used the Relaxation and Tension-Reduction Scale, Arousal and Aggression Scale, and Social Assertion Scale of the Alcohol Expectancy Questionnaire and modified its items to assess both alcohol and drug expectancies of 212 community-based, IPV-exposed women. Results of bivariate correlations showed that greater alcohol and drug expectancies were significantly correlated with greater alcohol problems and greater posttraumatic stress total and symptom severity scores. Results of a multivariate regression model showed that after controlling for demographic characteristics and history of childhood trauma, Relaxation and Tension- Reduction expectancies were associated with number of days of alcohol use, alcohol problems, physical and sexual IPV severity scores, and posttraumatic stress total and reexperiencing symptom severity scores. Expectancies do not significantly moderate the relationships between IPV, posttraumatic stress, and problematic alcohol and drug use. Given the strong relationships of expectancies with IPV severity, posttraumatic stress, and alcohol problems, expectancies may serve as targets for interventions to reduce alcohol use and problems and improve health-related outcomes in IPV-exposed women. 相似文献
103.
B. Guy Peters 《国际公共行政管理杂志》2013,36(9):1639-1668
The author argues that we do not really know how different the policymaking systems of developed and developing nations are. In his view, policymaking in less developed regimes is different from that which occurs in more affluent countries. However, the differences are frequently overstated. After analyzing several problems of the policymaking process, Peters concludes that the differences are larglely those of degree rather than of fundamentally different types of policy problems and processes. He concludes that what may matter is the degree of difficulty governments encounter in policymaking, and in some ways the less developed countries may actually enjoy some real advantages. At the same time, however, they have more informational, financial and ideological barriers that impose political limitations on policy learning. 相似文献
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Julia Peters Bruno Aubusson de Cavarlay Christopher Lewis Piotr Sobota 《European Journal on Criminal Policy and Research》2008,14(2-3):145-159
The subject of this article is a special type of fast-tracked case-ending decisions called “negotiated case-ending settlements”. Those proceedings are based on a kind of agreement between the parties, end with a real conviction of the offender and their legal consequence is a true but mitigated punishment. They can be found in six of 11 countries studied, namely, in England & Wales, Croatia, France, Hungary, Poland and Spain. The English guilty plea procedures, the French appearance before a court after prior admission of guilt and the Polish prosecutor’s application for a conviction to be rendered without a trial as well as the voluntary submission to penalty are examined more closely here. The comparative study focuses on the stage, where the negotiation is made, the conditions for the use of these settlements and the PPS’s role therein. 相似文献
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Ronald M. Peters Jr. 《The Journal of Legislative Studies》2013,19(1):136-154
This article examines the Armed Services Committee of the United States Houses of Representatives (HASC) at the beginning of the post‐cold war era. Utilising Fenno's 1973 framework, the article traces HASC's evolution through three periods: the ‘textbook’ period (1947–70); the transition period (1970–89); and the post‐cold war period (since 1989). It explores how changing environmental constraints and member goals have shaped its strategic premises, in Fenno's terms. Reporting on recent trends at HASC, I consider whether, in the post‐cold war era, HASC may be said to operate on the basis of any strategic premises at all. The article concludes by considering two key questions about Fenno's framework. Is it time bound? And, can it explain change? 相似文献
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