目的检测吗啡条件性位置偏爱(conditioned place preference,CPP)复燃大鼠杏仁核突触后致密质-95(PSD-95)的表达,探讨其在吗啡成瘾中对记忆的影响。方法 SD大鼠32只,随机分为吗啡依赖组(MD)、吗啡CPP消退组(ME)、环境激发组(MR)和对照组(N)。建立吗啡CPP模型,自然消退后,通过环境诱发CPP复燃,应用免疫组化和RT-PCR方法,观察检测激发组大鼠杏仁核PSD-95蛋白和mRNA表达,并与依赖组、消退组、对照组进行比较。结果吗啡CPP环境激发组、吗啡CPP消退组和对照组比较,杏仁核PSD-95的表达明显增加,具有高度显著性差异(P<0.01);吗啡依赖组与对照组比较,PSD-95的表达明显降低,具有高度显著性差异(P<0.01)。结论吗啡CPP环境激发组大鼠杏仁核PSD-95表达明显增高,PSD-95可能参与了成瘾记忆。 相似文献
This paper provides empirical evidence on the incentive role of personnel control in China in the twenty-first century. Employing the city-level turnover data of political leaders in China between 2000 and 2018 and utilizing the fixed effects ordered logit model, we find that the likelihood of promotion of local leaders rises with their economic performance. This relationship holds more firmly in the municipal party secretary. The probability is also found to decrease with the economic performance of their immediate predecessors and neighboring cities. This finding is robust to various robustness tests. We interpret the finding as evidence that the relative economic performance (peer effects) also contributes to the local political turnover, in particular within a province. Moreover, after the Third Plenary Session of the 18th CPC Central Committee, a material change in the personnel arrangement within the party arises and this promotion mechanism shows a dynamic change. Our study sheds some light on the growing literature emphasizing the relationship between political turnover and economic performance.