Medical,ethical and legal aspects of somatic gene therapy

Somatic gene therapy is one of the most fascinating and important medical developments as well as a field bearing unknown risks in human medicine of the nineties. This article tries to give a short survey on the medical applications of this new technique on the one hand and reflects possible ethical and legal implications on the other hand. We conclude that only an international agreement on risk assessment and ethical principles will lead to a adequate approach to somatic gene therapy.     

Book reviews

Karl‐Eugen Wädekin, Sozialistische Agrarpolitik in Osteuropa. II. Entwicklung und Probleme. 1960–1976. Berlin: Duncker & Humblot, 1978. 338 pp. DM62.

Peter Vanneman, The Supreme Soviet: Politics and the Legislative Process in the Soviet Political System. Durham, North Carolina: Duke University Press, 1977. xii + 256 pp. $11.75.

I. S. Koropeckyj (ed.). The Ukraine within the USSR: An Economic Balance Sheet. New York: Praeger Publishers, and London: Martin Robertson, 1977. xxi +316 pp. £14.85.

Dorothy Atkinson, Alexander Dallin, Gail Warshofsky Lapidus (eds.), Women in Russia. Hassocks, Sussex: Harvester Press, 1978. viii+410 pp. £11.50.

J. Wilczynski, Comparative Monetary Economics. London: Macmillan, 1978. x + 270 pp. £12.00.

David Turnock, Eastern Europe Studies in Industrial Geography. Kent: Dawson Publishing/Westview Press, 1978. xi+273 pp. £9.50.

Edward Allworth (ed.), Nationality Group Survival in Multi‐Ethnic States: Shifting Support Patterns in the Soviet Baltic Region. New York: Praeger Publishers, and London: Martin Robertson, 1977. xiv + 299 pp. £14.40.

Robert Conquest, Kolyma—the Arctic Death Camps. London: Macmillan, 1978. 256 pp. £6.95.

Vladimir G. Treml (ed.), Studies in Soviet Input‐Output Analysis. New York: Praeger Publishers, and London: Martin Robertson, 1977. xx + 448 pp.

Richard Hennessy, The Agrarian Question in Russia 1905–1907. The Inception of the Stolypin Reform. (Marburger Abhandlungen zur Geschichte und Kultur Osteuropas, Band 16.) Giessen: Wilhelm Schmitz Verlag, 1977. 203 pp.     

Comparative Metropolitan Organization: Service Production and Governance Structures in St. Louis (MO) and Allegheny County (PA)

For many observers, a large number of governments in a metropolitanarea is thought to equate to "fragmentation," and fragmentation,to ineffective organization and poor performance. Other observersfind a large number of local governments to mean competitionand consequent pressures for efficiency. The number of localgovernments, however, is only one dimension of the structureof a metropolitan area. We identify and measure key structuralcharacteristics of "fragmented " metropolitan areas, employinga comparative study of two metropolitan city-counties: St. LouisCityand County, Missouri, and Allegheny County (Pittsburgh),Pennsylvania. We argue that these areas, with their many unitsof local government, "work" by means of integrating structuresbuilt by local governments together with county and state governments.Counties, in particular, are a useful focus for study of metropolitanrelationships because they often provide the institutional framewithin which integrating structures are built.     

Organizational design and its consequences for administrative reform: Historical lessons from the U.S. Budget and Accounting Act of 1921

The landmark U.S. Budget and Accounting Act of 1921 (BAA) instituted a series of administrative reforms that proponents claimed would improve budgetary control, stability, and coherence. We maintain that the compatibility of governance structures between agency and system levels is critical for understanding why these administrative centralization efforts were successful in achieving these aims for some federal agencies but not others. The BAA reforms impact on budgetary outcomes is evaluated using panel data on major U.S. federal agencies between 1894 and 1940. Applying semiparametric heterogeneous treatment estimation techniques, we find compelling support that administrative centralization of the federal budgetary process enhanced budget stability and coherence for executive departments while resulting in a lower caliber of budgetary performance for independent agencies. These findings imply that system‐level administrative centralization efforts may be effective only when public agencies are structurally amenable to such reforms.     

Norfolk Island as Region: A Pacific Puzzle

Commonwealth‐enforced changes to the constitutional status of Norfolk Island through 2014–2016 have removed the island's autonomous identity as a self‐governing Australian territory. Its conversion to what is effectively a part of New South Wales, with the main instrument of governance titled ‘regional council’, is said to be based on a NSW local government model. However, it is difficult to view Norfolk Island as a region, and difficult also to trace the thinking that bestowed the form of the regional council on its governance. This article briefly summarizes the Norfolk changes. It then considers how the concept of the regional council has been used in NSW, and moves on to Queensland where the concept is better defined. It notes particularly how it has been applied in the case of the Torres Strait Islands, and asks whether that application might have relevance for Norfolk. It concludes with speculation about what might be a better approach in designing a system of governance suitable for Norfolk conditions.     

Bequests, sibling rivalry, and rent seeking

We examine bequest-sharing rules where sibling rivalry creates wasteful competition for intergenerational transfers. We show that equal division of bequests minimizes rent-seeking expenditures by siblings while primogeniture maximizes rent-seeking costs. Our results lend theoretical support to the empirical findings of equal bequests without appeal to complex models of the parent-child relationship.     

Evaluation of a community-based intervention to enhance road safety

A total of 300 motorists were recruited at public places to answer a self-report questionnaire on a new community-based intervention to enhance road safety. The intervention consisted of a speed-displaying device that was mounted next to the road and was visible to both motorists and the public. The device gives feedback about the current speed of the motorist. The majority of motorists believed these devices influenced compliance with the speed limit. They indicated they approached locations with these devices more slowly than similar locations without such devices. Moreover, they slowed down if they were going faster than the speed limit. They also said that their reaction to the devices was not influenced by whether they were driving in a community where they had friends or in a community where nobody knew them. These results were consistent across gender, age, levels of education, and professions.