The advanced technology program, its evaluation plan, and progress in implementation

The Advanced Technology Program (ATP) partners with U.S. businesses in high-risk research to develop enabling technologies with strong potential for economic benefits to the nation. Universities, nonprofit research laboratories, and firms of all sizes participate in ATP-funded projects. ATP’s evaluation effort seeks not only to measure the impacts of the technology development projects it funds, but also to understand the underlying relationships among research, technological change, and economic impact, and to provide feedback to the program to increase its broad-based benefits. Evaluation activities encompass developing models, conducting surveys, compiling databases, conducting micro- and macro-economic case studies, and performing statistical and econometric analyses. Program metrics include private rates of return, social rates of return, and public rates of return—the social-rate-of-return component attributable to the ATP. Topics of special interest, in addition to performance metrics, include spillover pathways, benefits and costs of collaboration, financing issues, and new models of impact assessment.     

Medical malpractice problem.

The medical malpractice problem is extremely complex and is perceived very differently by health care providers, patients, and other segments of society. As a widely recognized problem, it is of relatively recent origin. Its potential societal consequences include disruption of health services, waste and maldistribution of economic and human resources, and a severe strain on a variety of our traditional social institutions. The "crisis" of malpractice is a product of many forces, including a disturbing level of negligent and improper medical care, frequently unrealistic patient expectations, and the growing "philosophy of entitlement" which is rampant among Americans. Responses to the problem have sometimes been ill-advised and emotional. Most often, the problem is seen as one of inadequate or overpriced malpractice insurance, though careful analysis suggests that insurance issues are merely symptoms of the real problem. Nevertheless, insurance-based solutions have proven to be politically expedient and have produced at least temporary alleviation of the problem. Ultimately, though, other approaches will be necessary, and careful, objective research is required to identify and test long-term options.     

Rational and Pluralistic Approaches to HAVA Implementation: The Cases of Georgia and California

The Help America Vote Act (HAVA) has created a new dynamic forthe oversight and implementation of federal elections, requiringstates to assume greater control of election processes vis-à-vistheir local governments than was previously the case in moststates. We consider how HAVA has changed the relationship betweenstates and localities, especially through the HAVA planningprocess. We examine two approaches that states have used inHAVA planning—a rational approach and a pluralistic approach—andhow each can shape the power relationship between states andlocalities. We then present case studies from Georgia and Californiato illustrate how these two approaches have functioned in practice.     

Aqueous phase hexylchloroformate derivatization and solid phase microextraction: determination of benzoylecgonine in urine by gas chromatography-quadrupole ion trap mass spectrometry.

A derivatization/solid phase microextraction (SPME) method for the determination of benzoylecgonine in urine was developed. The derivatization is conducted directly in 1 mL of urine while sonicating for 3 min with 12 microL of hexyl chloroformate and 70 microL of a mixture containing acetonitrile:water:hexanol:2-dimethylaminopyridine (5:2:2:1 v/v), yielding benzoylecgonine hexyl ester (BHE) as the product. After the 3 min period, an aliquot of 250 microL is transferred to a vial for SPME. After the desired extraction time the 100 microns polydimethylsiloxane SPME fiber was transferred to the GC-MS for separation and analysis with a quadrupole ion trap mass spectrometer. The hexyl chloroformate derivatization and SPME procedures were optimized for compatibility and sensitivity. The method was found linear for 0.10 to 20.0 micrograms/mL (r2 = 0.999) of benzoylecgonine in urine using benzoylecgonine-d3 as an internal standard (1.5 micrograms/mL). Intra-day precisions were 8.8 and 6.8% RSD for 0.30 microgram/mL and 17 micrograms/mL benzoylecgonine standards in urine (n = 6), respectively. Inter-day precision (n = 3) were < or = 3.3% RSD, indicating good reproducibility. A detection limit of 0.03 microgram/mL (S/N = 3) was achieved, thus making the SPME method a simplified alternative to SPE for GC-MS confirmation after EMIT tests for benzoylecgonine which have a cutoff of 0.30 microgram/mL. Quantitative results by SPME and SPE of two clinical urine specimens known positive for cocaine by EMIT were in excellent agreement. Benzoylecgonine was detected by the derivatization/SPME method in 22 out of 22 other urine specimens known positive for cocaine.     

Chrysomya rufifacies (Macquart) (Diptera: Calliphoridae) established in the vicinity of Knoxville, Tennessee, USA

The hairy maggot blow fly, Chrsomya rufifacies (Macquart) (Diptera: Calliphoridae) was collected in large numbers as both adults and immatures in the Knoxville, Tennessee, area during 1998 and is likely established there. The distribution of this species in the Old World, isothermal data, and its collection from mid-Michigan during 1998 suggest that it will eventually occupy most of the U.S. The forensic importance of C. rufifacies makes it probable that it will factor into an increasing number of medicolegal cases, but the expanding distribution of this species decreases its utility as a geographic indicator when postmortem movement of decedents is suspected.     

The conduct of socially sensitive research: sex offenders as participants

This article examines some extra-research variables inherent in conducting community-based research with child molesters and other sex offenders. These include such issues as informed consent with court-referred participants, confidentiality when interagency collaboration is necessary, and duty to take proper care. Methods for establishing the scientific credibility of the project, responding to client grievances, dealing with client crises, and protecting staff and the surrounding community also are addressed. Adopting procedures similar to those described here could be an important step in ensuring the viability of other socially sensitive research projects.     

Reviews

László Csaba, ed., Systemic Change and Stabilization in Eastern Europe. Aldershot, and Brookfield, NY: Dartmouth Publishing Co., 1991, x + 141 pp. £30.00.

Christopher T. Saunders, ed., Economics and Politics of Transition. New York: Macmillan Press, 1992, x + 419 pp., £50.00.

David Lane, Soviet Society under Perestroika, Completely revised edition. London and New York: Routledge, 1992, xvi + 441 pp., £15.99.

Judith B. Sedaitis & Jim Butterfield, eds, Perestroika from Below: Social Movements in The Soviet Union. Boulder, CO, San Francisco, CA, and Oxford: 1991, xii + 220 pp., $23.00 h/b.

Michael J. Sodaro, Moscow, Germany, and the West from Khrushchev to Gorbachev. London: I. B. Tauris, 1991, xiv + 423 pp., £29.95.

Örjan Sjöberg, Rural Change and Development in Albania. Boulder, CO, San Francisco, CA, and Oxford: Westview Press, 1991, xi + 199 pp., £21.95 p/b.

Anthony Kemp‐Welch, ed., The Ideas of Nikolai Bukharin. Oxford: Clarendon Press, 1992, 209 pp., £27.50.