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231.
Haplotype, allele frequencies and population data of eight Y-chromosome STR loci, DYS437, DYS438, DYS439, GATA A10, GATA A7.1, GATA A7.2, GATA C4 and GATA H4, were determined from a sample of 212 unrelated male individuals from Galicia (NW of Spain).  相似文献   
232.
Cell line DNA typing in forensic genetics--the necessity of reliable standards   总被引:15,自引:0,他引:15  
The incorporation of reference DNA is crucial to the validation of any DNA typing protocol. This paper aims to provide a panel of reference DNAs for actual forensic profiling strategies, i.e. autosomal and gonosomal STR typing as well as mtDNA sequencing. We have characterised three human lymphoid cell lines, GM9947, GM9948 and GM3657, and considered 58 autosomal and gonosomal microsatellites as well as the mitochondrial control region sequence. Well-established markers and STRs recently developed for forensic use were involved. K562 DNA samples which we purchased from two different suppliers were also analysed. They revealed conflicting results with regard to the ChrX STR marker genotype. Hence, we suggest that K562 is no longer used for the calibration of profiling techniques. Our investigation establishes a panel of one female and two male DNA samples as an STR allelic ladder calibration tool and offers information on six alleles of each autosome (AS) marker, three alleles of each X chromosome (ChrX) marker and two alleles of each ChrY marker. In addition, sequences of the mitochondrial control region of the three DNAs are communicated in order to provide sequencing quality control.  相似文献   
233.
The Spanish and Portuguese ISFG Working Group (GEP-ISFG) carried out a collaborative exercise in order to asses the performance of two Y chromosome STR tetraplexes, which include the loci DYS461, GATA C4, DYS437 and DYS438 (GEPY I), and DYS460, GATA A10, GATA H4 and DYS439 (GEPY II). The groups that reported correct results in all the systems were also asked to analyse a population sample in order to evaluate the informative content of these STRs in different populations. A total of 1020 males out of 13 population samples from Argentina, Brazil, Costa Rica, Macao, Mozambique, Portugal and Spain were analysed for all the loci included in the present study. Haplotype and allele frequencies of these eight Y-STRs were estimated in all samples. The lowest haplotype diversity was found in the Lara (Argentina) population (95.44%) and the highest (99.90%) in Macao (China). Pairwise haplotype analysis showed the relative homogeneity of the Iberian origin samples, in accordance with what was previously found in the European populations for other Y-STR haplotypes (http://www.ystr.org). As expected, the four non-Caucasian samples, Macao (Chinese), Mozambique (Africans), Costa Rica (Africans) and Argentina (Lara, Amerindians), show highly significant Phist values in the pairwise comparisons with all the Caucasian samples.  相似文献   
234.
Although it is difficult for local governments to give support for social welfare recipients top political priority, there are huge variations in the support recipients actually receive among Norwegian municipalities. However, local governments representing different party ideologies may prefer to support different dimensions of generosity. Some municipalities could have a liberal attitude to eligibility rules but be strict on time limits and the amount of money provided. Others may be generous regarding time limits or amounts received once one is accepted as a welfare client. Data from the mid 1990s indicate the variation in support is related to different generosity dimensions for different party groups. While the total number of clients seems unrelated to politics and basically correlates with local social problems, the duration and amount of support are related to the political composition of the municipality assembly. Devoid of any large variation, both time limits and the amount of support increase in accordance with socialist leanings, and the total budget used for social welfare support also increases with the proportion of women in the municipality assembly.  相似文献   
235.
This study examined individual differences in the relations among preadolescents' sociomoral understanding and self-understanding, teacher and peer ratings of school behavior. Two hundred and thirty-nine preadolescents (M = 11.9 years; 127 girls and 112 boys) completed tasks concerning perceptions of competence, vocabulary, and peer-rated social competence. Students also participated in a story-telling interview that assessed sociomoral understanding and self-understanding. Results indicated links between various self-concept dimensions and (a) teacher ratings of academic competence, peer aggression (both physical and relational), and prosocial behavior; and (b) general vocabulary ability. Both sociomoral understanding and self-understanding were found to be linked to perceived academic competence for boys only. Independent of vocabulary ability, girls scored higher than boys on perceived behavioral conduct, teacher ratings of relational aggression (Grade 6 only), and self-understanding, particularly a sense of self-agency. Content analysis showed that girls were more likely than boys to refer to their parents when discussing their sense of self-agency. Independent of vocabulary ability, boys scored marginally higher than girls on sociomoral understanding. Results are discussed in terms of curricular implications for inter- and intrapersonal understandings.  相似文献   
236.
Under investigation were effects of a course in sex education on a population of emotionally disturbed adolescents who were enrolled as day patients in a school program that is part of the Adolescent Treatment Program of the Institute of Pennsylvania Hospital. Pre- and posttesting of knowledge and attitudes and staff observation were used to measure changes. The results of the study indicated that patients responded age appropriately and gained knowledge and an increased openness about sexuality issues. In addition, there was no regression nor dysfunction as a result of the materials presented, and therapeutic and educational processes were not disrupted by the patients' involvement in the course. It was concluded that a sex education course is clinically and educationally useful on many levels within a therapeutic setting.Received M.S. from University of Pennsylvania. Research interests: Special education, Sex education.Received M.D. from Temple University School of Medicine. Research interests: Psychopathology of adolescence, treatment of seriously disturbed adolescents.Received Ph.D. from Hebrew University of Jerusalem. Research interests: Sexuality education.  相似文献   
237.
238.
In Britain, women academics occupy an elite position and therefore have not excited much feminist sympathy. Yet when compared to their male counterparts such women are clearly disadvantaged. This paper analyses three persistent problems British women academics typically encounter. The first involves the coordination, over time, of demands of two ‘greedy institutions’: home and work. The second is the management of colleague relations while occupying token status in a department. The third is the task of understanding and confronting biases reflecting male dominance in what is considered acceptable professional knowledge and practice. What links all three is the marginality, the ‘otherness’ of women academics. Their vulnerability is high and their political potential low; yet by advancing feminist scholarship they can turn their talents to good use.  相似文献   
239.
240.
Abstract: This paper examines the historical foundation of the legal framework of the duties and responsibilities of the civil servant. Historically the crown could not be sued in tort and it seemed appropriate then to sue the individual servant who had created the wrong. In the mid-twentieth century, the crown was made liable in tort vicariously, so the liability of the civil servant was preserved in order to set up the vicarious liability of the crown. Generally the crown indemnifies its servant. It is argued here that the vicarious liability of the crown, and the consequent need to keep the personal liability of the civil servant, is an anachronism which stands in the way of a proper airing of the issues between citizens and government. It favours neither the wrongdoer nor the wronged and should be abolished. Moreover, it leaves to the court the important policy questions which should be dealt with by the legislature on a conceptual basis, not by the court on a case-by-case ad hoc basis. Sommaire: Cette étude examine le fondement historique du cadre juridique des devoirs et des responsabilitks des fonctionnaires. Autrefois, il était impossible d'intenter une action én dommages-intérêts contre la Couronne; il fallait plutôt intenter une action contre le fonctionnaire responsable de l'acte délictueux. Au milieu du vingtième siècle, la Couronne s'est vu attribuer la responsabilité délictueuse du fait d'autrui, la responsabilité des fonctionnaires devant être conservée de façon à assigner la Couronne comme commettant. En général, aujourd'hui, la Couronne prend fait et cause pour ses fonctionnaires et les indemnise. L'auteur soutient que la responsabilité du fait d'autrui conférée à la Couronne et la nécessitié de maintenir la responsabilité personnelle du fonctionnaire sont des anachronismes qui font obstacle à un débat ouvert entre le public et le gouvernement. Ce système ne f avorise ni celui qui a commis le délit ni celui qui en a souffert, et devrait donc être aboli. De plus, il laisse aux tribunaux le soin de résoudre d'importants problèmes de politiques qui devraient être traités par le Parlement selon une approche conceptuelle et non par les tribunaux suivant les circonstances de chaque cas.  相似文献   
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