英国"托护"青少年的心理健康问题

托护(looked after)青少年是指父母无力监护、监护不力以及受到家庭虐待的青少年.这类由政府专门机构或寄养家庭收养的青少年,他们的心理健康问题复杂多样.     

Joseph’s Squinting Eye: Race and Individualism in Peter Matthiessen’s Shadow Country

Peter Matthiessen’s novel Shadow Country offers a fictionalized account of the life of real-life character Edgar Watson. Matthiessen’s portrayal illustrates Jack Turner’s argument in Awakening to Race that atomistic individualism both justifies an individual’s success as a product of that person’s hard work and masks the racial inequality on which that success is actually predicated. Turner advocates an “awakening to race” as an important step toward replacing atomistic individualism with democratic individualism in American society. Matthiessen’s work deepens Turner’s analysis by showing that the whiteness of Watson’s atomistic individualism is inflected by masculinity. Further, Matthiessen depicts the difficulty of awakening to race for many white Americans. The Edgar Watson narrative serves to show that while closing one’s eyes to race may appear to be an advantage for most white people, not awakening to race actually exacts a devastating psychological tax. That kind of insight, which approaching political theory through literature affords, may help white Americans circumvent psychological mechanisms of denial and acknowledge the difficult history of their country.     

Vascular changes in the nasal submucosa of chronic cocaine addicts

A detailed, correlative, histologic evaluation of postmortem changes in the nasal mucosa of chronic cocaine users has shown characteristic mucosal and arteriolar changes as well as typical perivascular and subepithelial alterations compatible with chronic inflammation. These findings confirm and extend recent reports on the effects of cocaine in the coronary circulation and heart muscle as well as provide a new diagnostic tool to the forensic pathologist who suspects that a decedent has been a long-term cocaine abuser.     

The general toxicology unknown. II. A case report: doxylamine and pyrilamine intoxication

A general toxicology unknown case is presented to demonstrate our systematic approach. A 20-year-old male was found dead with multiple suicide notes. Overdose was suspected but substances were not known. Blood alcohol was negative. Urine was analyzed by enzyme-multiplied immunoassay technique and was negative for all drugs assayed. Urine was then extracted with ethyl acetate:hexane (1:1) at pH 10 and back-extracted into 1.0N sulfuric acid. The acidic layer was adjusted to pH 10, and re-extracted with ethyl acetate:hexane (1:1). The residue was analyzed by gas chromatography (GC) on a 3% OV-101 column. It was found to be negative for all commonly screened substances. However, several unknown peaks were observed. Electron impact mass spectra of these unknown peaks were obtained and searched for in our computer library of more than 25000 mass spectra. These unknown peaks were identified as doxylamine and pyrilamine by gas chromatography/mass spectrometry. The base peak and molecular ion for pyrilamine were at m/z 121 and 285, respectively. The base peak for doxylamine was at m/z 58. No molecular ion was observed for doxylamine. Both doxylamine and pyrilamine are antihistamines, but are promoted and used in the management of insomnia. Quantitation was performed on a GC using dexbrompheniramine as an internal standard. Blood concentrations for doxylamine and pyrilamine were 0.7 and 7.0 mg/L, respectively. Concentrations in other tissues were determined. Death was caused by combined doxylamine and pyrilamine intoxication; the manner of death was suicide.