Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?

Pharmacogenomics, applied as an aspect of molecular autopsy, may be used as an adjunct for certifying methadone fatalities. Methadone is metabolized by cytochrome P-450 (CYP) 1A2, 3A4, and 2D6. We hypothesized that methadone toxicity may be partially due to CYP 2D6 *3, *4, and *5 variant alleles, resulting in poor drug metabolism. A retrospective analysis was performed on covariables and risk factors of 21 methadone cases from the Milwaukee County Medical Examiner's Office (1998-2000). PCR genotyping showed: one heterozygous for 2D6*3, two homozygous for 2D6*4, five heterozygous for 2D6*4, and one heterozygous for both 2D6*3 and *4. This limited number of cases showed that the prevalence of poor metabolizer was higher but not significantly different from that of a control group (n = 23) (P > 0.05, Fisher Exact Test). Thus, CYP 2D6 mutations may not yet be directly associated with methadone toxicity. However, pharmacogenomics, complementing other case findings, served as an adjunct in interpreting methadone toxicity of poor and intermediate metabolizers.     

The Spatial Patterning of County Homicide Rates: An Application of Exploratory Spatial Data Analysis

The possibility that homicides can spread from one geographic area toanother has been entertained for some time by social scientists, yetsystematic efforts to demonstrate the existence, or estimate the strength,of such a diffusion process are just beginning. This paper uses exploratoryspatial data analysis (ESDA) to examine the distribution of homicides in 78counties in, or around, the St. Louis metropolitan area for two timeperiods: a period of relatively stable homicide (1984–1988) and aperiod of generally increasing homicide (1988–1993). The findingsreveal that homicides are distributed nonrandomly, suggestive of positivespatial autocorrelation. Moreover, changes over time in the distribution ofhomicides suggest the possible diffusion of lethal violence out of onecounty containing a medium-sized city (Macon County) into two nearbycounties (Morgan and Sangamon Counties) located to the west. Althoughtraditional correlates of homicide do not account for its nonrandom spatialdistribution across counties, we find some evidence that more affluentareas, or those more rural or agricultural areas, serve as barriers againstthe diffusion of homicides. The patterns of spatial distribution revealedthrough ESDA provide an empirical foundation for the specification ofmultivariate models which can provide formal tests for diffusion processes.     

The size of second chambers and European assemblies

Abstract. Second chamber sizes (in terms of seats) tend to increase with increasing population like first chamber sizes. Population seems to affect first chamber size directly, while the size of the first chamber goes on to affect second chamber size. When selected on the basis of territorial sub-units, the second chamber size tends to be around the geometric mean of first chamber size and the number of sub-units. From the viewpoint of representing the total population and the constituent sub-units, the European Parliament is more akin to a first chamber and its size has been approaching the cube root of population typical of first chambers. The Council of the European Union (CEU) is more akin to a second chamber and its size, in terms of qualified majority voting (QMV) votes, was approaching the size typical of second chambers at a given population. However, the Treaty of Nice has boosted the CEU to a size comparable to that of the European Parliament (EP), which may not be functional. Analogies to domestic first and second chambers suggest that the optimal size for the 27-country CEU might be 150 to 190 seats (Nice proposes 345), while that for the EP might be around 780 seats (Nice proposes 732).     

Coping styles of learning disabled adolescents and their parents

The study compares coping styles of 50 learning disabled and nonlearning dis-abled adolescents and their parents. Analyses indicate that learning disabled adolescents show less ability to appraise a source of stress and seek information in the various domains with which they are expected to cope. Also, they reveal a higher level of pessimism about problems in academic-related domains. Coping patterns of parents of learning disabled adolescents do not show clear differences from parents of nonlearning disabled. Yet mothers of learning disabled adolescents tend more to seek and accept help. Learning disabled adolescents' coping is clearly related to coping or more specifically to difficulties in coping of their parents. Results are discussed in the context of the special difficulties of the learning disabled during adolescence and the role their parents play during this developmental stage.Received Ph. D. from Bar Ilan University. Research interests include developmental and family processes in normal and pathological adolescents.Received Ph.D. from University of Minnesota. Main interests are developmental and family processes in adolescence.Received M.A. in counseling from Tel Aviv University.Received M.A. in counseling from Tel Aviv University.     

The role of tax preparers in tax compliance

This paper assesses the influence of tax preparers on tax compliance. Using data from the Internal Revenue Service's (IRS) Taxpayer Compliance Measurement Program and an index of legal ambiguity based on Revenue Rulings, the impact of preparation mode (paid third party vs. self) on compliance at the level of the return line item is probed. The results suggest that preparers contribute to compliance by enforcing legally clear requirements but also contribute to noncompliance, as measured by the IRS, by helping taxpayers take advantage of legal ambiguity. Furthermore, an analysis of a campaign to enforce estimated tax requirements conducted by the Pennsylvania Department of Revenue suggests that tax preparers are also an important network for communicating tax agency enforcement priorities to taxpayers.An earlier version of this paper was prepared for the conference on Federal/State Research sponsored by the U.S. Internal Revenue Service.     

Adolescent autonomy and parental stress

The present investigation explores the relationship between adolescent autonomy and parental stress among families with children aged 10–17. Independent measures were obtained from parents and children. Parents of early adolescent children reported significantly more stress than parents of preadolescents or middle adolescents. Parents of first-born children reported significantly more stress than did more experienced parents. Although mothers and fathers reported comparable levels of overall parental stress, their stress was, in part, the result of different factors. Fathers reported higher levels of stress if their children reported not following their advice and being involved in deviant activities. For mothers, stress was significantly related to their children's desire for greater autonomy. Emotional detachment was not a significant predictor of parental stress for either mothers or fathers. Implications of the findings for the parent-child relationship during adolescence are discussed.Received Ph.D. from Cornell University in 1984. Research interests include parent-adolescent relations and the work-family interface.Research interests include home-school relations and parenting.Received Ph.D. in 1978 from the Pennsylvania State University. Research interests are in adult development and aging.