Initial Development of a New Measure of Minor Stress for Adolescents: The Adolescent Minor Stress Inventory

The primary aim of this study was to develop, standardize, and establish initial reliability and validity for the Adolescent Minor Stress Inventory (AMSI), a new measure of minor stress for adolescents. The AMSI improves upon existing adolescent stress measures in a number of important ways in that it does not emphasize school or classroom-based stressors, and includes a method of adjusting for the over- and underreporting of stress. In this investigation, the AMSI was mailed to 1865 adolescents aged 13–17 from which we obtained 720 (39%) usable surveys. Standardized scoring was developed and the results provide initial data supporting the factor structure, reliability, and validity of the AMSI. The AMSI has potential application both in clinical and research settings, particularly during times when school is not in session or with adolescents who do not regularly attend school.Assistant Professor, Division of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida. Received PhD in Clinical Psychology from Louisiana State University in 1999. Research interests include psychological stress and nicotine dependence treatment in adolescents and young adults.Professor Emeritus, Division of Biostatistics, Mayo Clinic, Rochester MN. Received MS in Statistics from Iowa State University in 1971. Research interests include survey research, nicotine dependence treatment, and biostatistics.Data Analyst, Division of Biostatistics, Mayo Clinic, Rochester, Minnesota. Received BS in Applied Statistics from Rochester Institute of Technology in 2000. Research interests include nicotine dependence and survey methods.Associate Professor, Nicotine Dependence Program, Mayo Clinic, Rochester, Minnesota. Received PhD in Clinical Psychology from University of California, San Diego in 1996. Research interests include nicotine dependence in adolescents.Professor, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota. Received PhD in Clinical Psychology from University of North Dakota in 1980. Research interests include impact of trauma.Statistician, Division of Biostatistics, Mayo Clinic, Rochester, Minnesota. Received MS in Applied Mathmatics from University of Minnesota, Duluth in 1999. Research interests include nicotine dependence.Professor, Nicotine Dependence Center, Mayo Clinic, Rochester, Minnesota. Received MD from University of Louisville in 1970. Research interest in area of tobacco dependence.     

The rapid analysis of heroin drug seizures using micellar electrokinetic chromatography with short-end injection

A simple and rapid method for the analysis of heroin seizures by micellar electrokinetic chromatography with short-end injection is described. Separations were performed using an uncoated fused silica capillary, 50 cm x 50 microm I.D. x 360 microm O.D. with an effective separation length of 8 cm. The system was run at 25 degrees C with an applied negative voltage of -25 kilovolts. Injection of each sample was for 2 s at -50 mbar. UV detection was employed with the wavelength set at 210 nm. The background electrolyte consisted of 85:15 (water:acetonitrile, v/v) containing final concentrations of 25 mM SDS and 15 mM sodium borate, pH 9.5. Samples and standards were prepared in 0.1% v/v acetic acid and diluted in the run buffer containing 1 mg/ml of N,N-dimethyl-5-methoxytryptamine as an internal standard. Under these conditions a text mixture containing caffeine, paracetamol, morphine, codeine, heroin, and acetylcodeine was resolved within 1.5 min. The method was used to determine the concentration of heroin in heroin seizure samples, and the results were in good agreement with those obtained by a validated gas chromatographic method.     

Disposition of quetiapine in biological specimens from postmortem cases

Quetiapine is a new atypical antipsychotic that was approved in 1997 by the U.S. Food and Drug Administration for the treatment of schizophrenia. It possesses a high affinity for 5-HT2 receptors and a low affinity for D1 and D2 dopamine receptors. Because quetiapine has only been released recently to the U.S. market, little information exists regarding therapeutic, toxic, and lethal concentrations. This study reports the detection of quetiapine in 13 postmortem cases. Following a basic liquid-liquid extraction, quetiapine was identified and quantitated by capillary gas chromatography with nitrogen phosphorus detection. Confirmation was accomplished by full scan electron impact gas chromatography/mass spectrometry. Heart blood quetiapine concentrations ranged from 0.07 to 18.37 mg/L (N = 12, mean +/- SD = 3.42 +/- 5.67, median 0.62) and femoral blood concentrations ranged from 0.06 to 19.25 mg/L (N = 10. mean +/- SD = 3.89 +/- 6.12, median 0.81). The average heart blood/femoral blood ratio was 1.31 (range 0.55 to 2.57, N = 10). Urine, bile, and gastric contents were assayed in all cases in which they were submitted. In three cases, the cause of death was determined to be quetiapine toxicity. In these cases heart blood concentrations ranged from 0.72 to 18.37 mg/L (N = 3). These data may provide a basis for establishing levels associated with quetiapine toxicity as well as therapeutic concentrations in postmortem specimens.     

Population data for the AMPFlSTR Profiler plus STR loci from residents of the Australian Capital Territory (ACT)

Profiler Plus-Resident donors (N=620) from the Australian Capital Territory (ACT). Although the ethnicity of the donors was not recorded the population of the ACT is largely homogeneous, with over 96% of respondents declaring their ancestry as Caucasian in the 2002 National Census.     

Alkaloid content of the seeds from Erythroxylum Coca var. Coca

Alkaloid extracts from the seeds of Erythroxylum Coca var. Coca grown in the Chapare Valley of Bolivia were subjected to gas and liquid chromatographic-mass spectrometric analyses. Several alkaloids from these seeds were detected and characterized, including methylecgonidine, tropine, 3alpha-acetoxytropane, ecgonine methyl ester, cuscohygrine, N-norbenzoyltropine, benzoyltropine, hexanoylecgonine methyl ester, cocaine, cis-cinnamoylcocaine, and trans-cinnamoylcocaine. Methylecgonidine was determined to be the primary constituent and not an analytical artifact. Additionally, two significant new uncharacterized alkaloids were established as present. Recent evidence suggests that some cocaine processors are adding this seed extraction material to cocaine extracted from coca leaf and may impact cocaine impurity signature profiles.     

The ‘science’ of superiority: Africa and scholarly colonial assumptions

ABSTRACT

The use of ‘neopatrimonialism’ as a category in mainstream scholarship on African polities and economies is ubiquitous. A critique by Thandika Mkandawire has shown that the ‘neopatrimonial school’ is devoid of conceptual coherence and analytical power – it is an expression of a prejudice, not a useful tool for research and analysis. The article endorses Mkandawire's view but points out that this is by no means the only example of its kind. On the contrary, the use of categories which assume the superiority of societies in the global North over those in Africa is widespread. The article illustrates this by discussing and criticising two others, the ‘democratic consolidation’ paradigm and the ‘failed state’ framework. It argues that all three shape assumptions by scholars in Africa as well as outside it which obstruct concrete analysis. A critique of these paradigms is thus essential to the development of scholarship on and about Africa.     

Abolishing Illiteracy and Upgrading Culture: Adult Education and Revolutionary Hegemony in Socialist Laos

ABSTRACT

This article examines the monopolisation of political space by the Lao People’s Revolutionary Party, before and after 1975. Together with coercive measures, the Marxist-Leninist regime consolidated rule by establishing and disseminating new concepts of state power, social responsibility and socialist subjectivity, which formed the basis of a radical form of revolutionary hegemony. The Party propagated a new rhetoric of rule through mandated activities including village meetings, co-operatives and a much expanded but poor-quality mass education system. This article examines the system of adult education, where the Party sought to eradicate illiteracy and “upgrade culture” among economically productive 15 to 45-year-olds. Motivated by both politics and pedagogy, the Party imported this system from the Democratic Republic of Vietnam in the 1960s before institutionalising it after 1975. The resulting organisational structure fanned the rhetoric of rule across the national territory in an extensive manner that reached the illiterate “masses” in large numbers. Even where the programme encountered material shortages and apathy, mandated participation in adult education propagated the vocabulary and grammatical structure of socialist Laos, providing a codebook for how to participate in socialist society.     

This stillness,this lack of incident: making conflict visible in West Papua

This article examines how the ongoing conflict in West Papua between state security forces and Papuan independence activists is made visible in activist social media postings in their attempts to draw attention to the violence, abuses, and problems in Indonesia’s easternmost province. The use of social media may provide new avenues for raising awareness about the conflict and its consequences. However, a social media strategy that contrasts the innocence and justness of the Papuan people with the violence and barbarity of other Indonesian peoples and the state risks entrenching established tropes which may serve to discourage broader support for West Papuan pleas for justice and independence.     

Reviews

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