Near Infrared Spectroscopy Detection and Quantification of Herbal Medicines Adulterated with Sibutramine

There is an increasing demand for herbal medicines in weight loss treatment. Some synthetic chemicals, such as sibutramine (SB), have been detected as adulterants in herbal formulations. In this study, two strategies using near infrared (NIR) spectroscopy have been developed to evaluate potential adulteration of herbal medicines with SB: a qualitative screening approach and a quantitative methodology based on multivariate calibration. Samples were composed by products commercialized as herbal medicines, as well as by laboratory adulterated samples. Spectra were obtained in the range of 14,000–4000 per cm. Using PLS‐DA, a correct classification of 100% was achieved for the external validation set. In the quantitative approach, the root mean squares error of prediction (RMSEP), for both PLS and MLR models, was 0.2%w/w. The results prove the potential of NIR spectroscopy and multivariate calibration in quantifying sibutramine in adulterated herbal medicines samples.     

Microscopic Pattern of Bone Fractures as an Indicator of Blast Trauma: A Pilot Study

The assessment of fractures is a key issue in forensic anthropology; however, very few studies deal with the features of fractures due to explosion in comparison with other traumatic injuries. This study focuses on fractures resulting from blast trauma and two types of blunt force trauma (manual compression and running over), applied to corpses of pigs; 163 osteons were examined within forty fractures by the transmission light microscopy. Blast lesions showed a higher percentage of fracture lines through the Haversian canal, whereas in other types of trauma, the fractures went across the inner lamellae. Significant differences between samples hit by blast energy and those runover or manually compressed were observed (p < 0.05). The frequency of pattern A is significantly higher in exploded bones than in runover and compressed. Microscopic analysis of the fracture line may provide information about the type of trauma, especially for what concerns blast trauma.     

What Determines Foreign Policy in Latin America? Systemic versus Domestic Factors in Argentina,Brazil, and Mexico, 1946–2008

Is it domestic politics or the international system that more decisively influences foreign policy? This article focuses on Latin America's three largest powers to identify patterns and compare outcomes in their relations with the regional hegemon, the United States. Through a statistical analysis of voting behavior in the UN General Assembly, we examine systemic variables (both realist and liberal) and domestic variables (institutional, ideological, and bureaucratic) to determine their relative weights between 1946 and 2008. The study includes 4,900 votes, the tabulation of 1,500 ministers according to their ideological persuasion, all annual trade entries, and an assessment of the political strength of presidents, cabinets, and parties per year. The findings show that while Argentina's voting behavior has been determined mostly by domestic factors and Mexico's by realist systemic ones, Brazil's has a more complex blend of determinants, but also with a prevalence of realist systemic variables.     

A Natural Experiment in Political Decentralization: Local Institutions and Citizens' Political Engagement in Uruguay

The potential democratizing effect of political decentralization reforms has been a matter of substantial theoretical and empirical debate. This article analyzes the effect of local democratic institution building on the political attitudes and behavior of citizens living in small towns in Uruguay. More specifically, using a natural experiment design, this research seeks to establish the causal impact of recently established elections of local authorities on individuals' political engagement. It develops a comparative case study analyzing the consequences of this institutional innovation in two towns. It shows that individuals from the town where citizens have the opportunity to elect their local authorities have more positive attitudes toward politics than those from the town without such elections.     

Analysis of cognitive inhibition and flexibility in juvenile delinquents

Executive functions are still developing during adolescence. It is important to analyse if juvenile delinquency is related to a delay in the development of these functions. The objective of this study was to analyse cognitive inhibition and flexibility, two components of executive functions, in juvenile delinquents. Participants were 81 males, 17.46 ± 1.60 years old. Three groups were compared: a juvenile delinquent inmate group (IG), an age-paired group (APG), and an age- and education-paired group (AEPG). A modified Stroop task was used to assess cognitive inhibition and flexibility. The IG and the AEPG (low-education adolescents) had significantly more difficulties than the APG on inhibition; the IG and the AEPG had no significant differences. No group differences were found on flexibility. Since all low-education adolescents have difficulties on inhibition, these difficulties are not an exclusive characteristic of juvenile delinquents. Analysis of cognitive processes in juvenile delinquents must control for education to determine how specific are the difficulties found in these adolescents.     

Evaluation and policy learning: The learners' perspective

This article examines how evaluation induces policy learning – a question largely neglected by the scholarly literature on evaluation and policy learning. Following a learner's perspective, the article attempts to ascertain who the learners are, and what, and how, learners actually learn from evaluations. In so doing, it focuses on what different types of learners actually learn within the context of the evaluation framework (the set of administrative structures defining the evaluation goals and process). Taking the empirical case of three EU programme evaluations, the patterns of policy learning emanating from them are examined. The findings are that only two types of actors involved in the evaluation are actually learning (programme units and external evaluators), that learners learn different things (programme overview, small‐scale programme adjustments, policy change and evaluation methods) and that different learners are in control of different aspects of the evaluation (learning objectives and processes) according to the evaluation framework established by the European Commission.     

Focusing Events and Changes in Ecologies of Policy Games: Evidence from the Paraná River Delta

Solving environmental problems on a regional scale demands joint efforts by multiple stakeholders, but coordinating such efforts can be difficult in complex governance systems. In this article, we combine the literature in Adaptive Governance with the Ecology of Policy Games (EPGs) framework to enhance our understanding of how complex governance systems react to environmental focusing events. We study the EPGs in the Paraná River delta in Argentina following widespread fires caused by slash‐and‐burn practices in 2008, and analyze how new forums created to address the consequences of this event differ from the forums created prior to the event in terms of their capacity to attract stakeholders and to provide higher interconnectivity to the whole governance system. Furthermore, we offer an initial evaluation of the Comprehensive Strategic Plan for the Conservation and Sustainability of the Paraná River delta, the main forum in the EPGs created to address the negative consequences of the focusing event. Finally, we discuss the implications of our findings for the study of complex governance systems where stakeholders are able to address the management of natural resources at a regional scale.     

To adapt or to disregard? Parties’ reactions to external shocks

How do parties react to unanticipated events such as external shocks? Do they adapt to the consequences of the external shock or do they disregard them? Using the global financial crisis as an empirical example and testing the expectations for parties’ economic policy shifts in 23 European democracies based on Chapel Hill Expert Survey data, the article demonstrates that government parties react more to an external shock than opposition parties, particularly in countries where the external shock has been more severe. This has implications for a broader literature in comparative politics by fostering the dialogue between the political economy literature on external shocks and the literature on party policy shifts by showing the significant impact exogenous events can have on party positioning.     

Bureaucratization in a Changing Society: Administrative Reforms in Late Nineteenth Century Chile

During the 1880s, a significant number of Chilean administrative services were reformed following the characteristics of the Weberian bureaucracy. From the analysis of two cases of administrative reform (the so-called Prussianization of the Chilean Army and the creation of institutions in the field of public health), this article seeks to understand why bureaucracy gained ground in nineteenth century Chile. Specifically, the article discusses how social conditions led policy makers to choose bureaucracy as a model for administrative organization. Through this analysis, the article aims to contribute to the theoretical discussion on the causes of bureaucratization.