Analysis of Ecstasy Tablets Using Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection

A method for the identification of 3,4‐methylenedioxymethamphetamine (MDMA) and meta‐chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C⁴D). Sample extraction, separation, and detection of “Ecstasy” tablets were performed in <10 min without sample derivatization. The separation electrolyte was 20 mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04 mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE‐C⁴D and compared against routine gas chromatography‐mass spectrometry (GC‐MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90 sec. The advantages of using C⁴D instead of traditional CE‐UV methods for in‐field analysis are also discussed.     

Policy Monitoring and Ministerial Survival: Evidence from Multiparty Presidentialism

Studies on policy monitoring and ministerial survival within coalition governments are usually conducted separately. In this study, we bring these topics together and argue that the strategy of coalition partners to oversee the implementation of one another's policies has surprising consequences on the duration of office-holding ministers. Our main theoretical insight suggests that the degree to which ministers behave as faithful agents of the government depends on their expectations about their partners' monitoring behavior, such that when they expect to be under high scrutiny, they moderate their drifting behavior. Using evidence from legislative information requests on the activities of individual ministers over all multiparty cabinets formed in Brazil between 1995 and 2014, we demonstrate that: (1) greater policy monitoring by coalition partners is observed under more ideologically heterogeneous cabinets, and (2) more frequent policy-monitoring efforts by coalition partners lead to a lower ministerial replacement within the government term.