Forensic analysis of carbohydrate-deficient transferrin (CDT): implementation of a screening and confirmatory analysis concept is hampered by the lack of CDT isoform standards

The aim of the study was to test combinations of commercially available carbohydrate-deficient transferrin (CDT) assays for their usefulness as screening and confirmatory CDT analysis systems. A set of 292 serum samples from routine CDT analysis was analyzed by two assays based on anion-exchanger microcolumn CDT and non-CDT fractionation followed by a turbidimetric immunoassay (ChronAlcoI.D. and %CDT TIA) and a high-performance liquid chromatography with on-line sample preparation (ClinRep CDT on-line). The CDT analysis results were divided into four groups based on the test-specific borderlines of the compared methods: NN with negative CDT results by both tests, PN with positive screening but negative confirmation results, NP with negative screening and positive confirmation results, and PP with positive results by both tests. Regardless of the test combination and whether applying the lower or upper limits of the borderlines, approximately one-third of contradictory (positive screening and negative confirmation or vice versa corresponding to groups PN and NP) were obtained. This was not due to analytical outliers (only 6 of 292 serum samples). Indeed, parametric and non-parametric ANOVA analysis pointed to different calibrations and/or recoveries of the three CDT assays. Our data give again evidence for the urgent need of an international CDT isoform standard material. At this time, we cannot recommend a combination of the three tests for screening and confirmatory analysis in forensic CDT testing.     

Pares Inter Pares? The Bargaining Success of the Commission,the Council,and the Parliament in European Union Legislative Negotiations

This research note tries to determine how politically successful the Council, the Commission, and the European Parliament are in the area of EU legislative decision‐making. After reviewing the literature, a research design is presented which incorporates information on the policy preferences of the different institutional actors for 70 recent EU legislative decisions that were negotiated under the consultation and the codecision procedure. We use correlation and OLS regression to analyze the distances between what the EU institutional actors want and what they eventually get out of the process. The findings of the analysis are that (1) the preference profiles of the three actors are rather dissimilar, and that (2) the success rates of the Council are higher than the rates of the Commission and Parliament.     

Does Power Drive Out Trust? Relations between Labour Market Actors in Sweden

Although power and trust are crucial to human cooperation, and considerable attention has been paid to both these concepts in the social sciences, the relationship between them has been poorly investigated. In this article, based on data about a complete network of labour market actors in Sweden, it is investigated whether power 'drives out trust' or if power is a requirement of trust. In contrast to previous research, the article concludes that there is a positive relationship between power and trust, although it levels out when power is at a very high level. Also in disagreement with previous findings, it is shown that symmetry in power relations is not a guarantee of trust: two actors with symmetric low power do not trust each other, at least not in this specific institutional setting. Moreover, the theoretical argument is developed and refined by showing that shared beliefs and group membership also have an independent impact on trust, as well as a perception that the other actor is pursuing the common good. Hence, the presumed negative impact of power on trust is not only neutralised, but also transformed into a positive impact in the social context investigated here. However, more research is needed to show whether this finding is true only within certain institutional settings and, if so, within which ones.     

The role of social learning in adaptiveness: insights from water management

The article introduces the notion of adaptiveness and discusses the role of social learning in it. Adaptiveness refers to the capacity of a social actor or social–ecological system to adapt in response to, or in anticipation of, changes in the environment. We explore arguments both from a theoretical perspective and through illustrations from case studies of water management in the Alps of Europe and Mekong in southeast Asia. We propose and illustrate that social learning processes are important for building adaptiveness in several ways and at different scales. Social learning can help cope with informational uncertainty; reduce normative uncertainty; build consensus on criteria for monitoring and evaluation; empower stakeholders to take adaptive actions; reduce conflicts and identify synergies between adaptations; and improve fairness of decisions and actions. Findings in the case studies provide some support for these generalizations but often with caveats related to diversity of stakeholder interests, levels of shared understanding versus contested knowledge and scale of coordination. For this reason, we suggest that future work pays greater attention to issues of agency, knowledge and scale: What strategies have individuals and organizations pursued in successful examples of social learning? How are the boundaries and interactions between science, policy and practice managed? How does social learning occur across spatial and temporal scales?     

Politicisation of the EU Budget: Conflict and the Constraining Dissensus

The current political climate in the European Union, referred to as the ‘constraining dissensus’, may place negotiations on the multiannual EU budget centre stage. Media framing of EU budget negotiations as conflict between member states may reinforce the constraining dissensus by resonating with exclusive national identity. In contrast, media emphasis on conflict within or across member states may alleviate the constraining dissensus by strengthening cross-cutting cleavages. This study tests hypotheses about patterns in politicisation of the EU budget in three budgets (Delors II, Agenda 2000, Financial Perspectives 2007–2013), three countries (the Netherlands, Denmark and Ireland) and two forums (media and national parliaments). It finds predominant international conflict framing, especially in media. Thus, media coverage of EU budget negotiations likely reinforces the constraining dissensus. However, as debates intensify, the constraining dissensus may be loosened through more pluralist framing in the debates. Further comparative empirical research into the dynamics of politicisation is called for.     

Case Studies and EU Politics: A Reply to Miklin

A recent article in West European Politics by Eric Miklin attempted to shed light on the decision-making process in the European Union. The argument presented was that individual ministerial ideological preferences can affect a government's bargaining position in the Council of the European Union. Miklin proposes that under certain conditions national ministers may enjoy substantial freedom. This brief reply identifies three main problems with Miklin's approach: a case selection bias, ministerial autonomy, and an examination of where decisions are made.