Suicide via insulin overdose in nondiabetics: the New Mexico experience

Four cases of self-injected insulin overdose in nondiabetic individuals are presented. Included are two cases of presumed insulin overdose (no autopsy), one case with elevated vitreous insulin (autopsy), and one case with elevated postmortem blood insulin and low blood C peptide (autopsy). These cases demonstrate the need for a thorough scene investigation, complete autopsy, and proper collection and storage of specimens to certify a death caused by insulin intoxication as well as to determine the manner of death. Appropriate collection and preservation of postmortem blood samples are discussed.     

Fatal intravenous fentanyl abuse: four cases involving extraction of fentanyl from transdermal patches

The transdermal fentanyl system delivers a specific dose at a constant rate. Even after the prescribed application time has elapsed, enough fentanyl remains within a patch to provide a potentially lethal dose. Death due to the intravenous injection of fentanyl extracted from transdermal patches has not been previously reported. We present 4 cases in which the source of fentanyl was transdermal patches and was injected. In all of these cases, the victim was a white male who died at home. Case 1 was a 35-year-old with no known history of drug use, who was found by his wife on the floor of his workshop. Police recovered a fentanyl patch, needle, and syringe at the scene. Case 2 was a 38-year-old with a known history of drug use whose family claimed that he was in a treatment program that used fentanyl patches for unknown reasons. His brother found him dead in bed, and law enforcement officers found a hypodermic needle beside the body; a ligature around his left hand, and apparent needle marks between his first and second digits were also noted. Case 3 was a 42-year-old with a recent attempted suicide via overdose who was found dead at his home. An empty box of fentanyl patches, Valium, Ritalin, and 2 syringes were found at the scene. Case 4 was a 39-year-old found by his mother, who admitted to removing a needle with attached syringe from the decedent's arm. Medications at the scene included hydrocodone, alprazolam, zolpidem, and fentanyl patches. All reported deaths were attributed to fentanyl intoxication, with blood concentrations ranging from 5 to 27 microg/L.     

The application of an automated allele concordance analysis system (CompareCalls) to ensure the accuracy of single-source STR DNA profiles

A powerful method for validating a scientific result is to confirm specific results utilizing independent methodologies and processing pathways. Thus, we have designed, developed and validated an automated allele concordance analysis system (CompareCalls, patent pending) that performs comparisons between two independent DNA analysis platforms to ensure the highest accuracy for allele calls. Application of this system in a quality assurance role has shown the potential to eliminate greater than 90% of the STR analysis required of a DNA data analyst. While this system is broadly applicable for use with any two independent STR analysis programs, either prior to or following human data review, we are presenting its application to data generated with the ABI Prism Genotyper software system versus data generated with the SurelockID system. With the automated allele concordance analysis system, the GeneScan DNA fragment data generated from an ABI 377 gel image are analyzed in two independent pathways. In one analysis pathway, the GeneScan data are imported into Genotyper software where STR labels are assigned to the fragment data based upon the criteria of the Kazam 20% macro. The "Kazam" macro provided with the Genotyper program works by labeling all peaks in a category (or locus) and then filtering (or removing) the labels from peaks, such as those in stutter positions, that meet predefined criteria. In the second pathway, the GeneScan data are imported into the SurelockID analysis platform where STR labels and error messages are assigned to the fragment data based upon hard-coded allele calling criteria and quality parameters. The resulting STR allele calls for each analysis platform are then compared, utilizing the automated allele concordance analysis system. Any differences in the STR allele calls between the two systems are flagged in a discordance report for further review by a qualified DNA data analyst. The automated allele concordance analysis system guides the DNA data analyst to the discordant data generated by either analysis platform. Additionally, the analyst is also directed to data that are of less than pristine quality which may have an increased potential for errors in interpretation by either analysis platform or by a human DNA data analyst. Implementation of an automated allele concordance analysis system will yield high-quality data for CODIS and free the human DNA data analyst to perform other critical duties within the laboratory.     

On the pricing and benefit structure of a private club or public utility

In this study the structure-induced equilibrium approach for modeling democratic institutions is extended to allow for the added structural features of executive veto and legislative override. A multidimensional model is presented for a budgetary process involving three actors — a legislature, an appropriations committee, and an executive. In order to focus attention on the role of the veto and override possibilities, simplifying assumptions are made with regard to other aspects of the agenda formation process. In particular, the committee has monopoly agenda power, a closed amendment control rule is operative, and perfect-foresight expectations are held by the committee and the executive. Given these assumptions, utility maximization by the several actors generates a budget outcome characterized as a structure-induced equilibrium. The general model is illustrated geometrically with a two-dimensional example, permitting budget outcomes to be analyzed for various combinations of veto rules and override provisions. The analysis demonstrates that budget outcomes are sensitive to alternative specifications of veto rules and override provisions. In the illustration, executive veto power is shown to vary directly with both the permissiveness of the veto rule and the stringency of the override provision. Similar relationships, however, are not found to exist for total budget expenditures.     

An analysis of the effects of gender on outcome in group treatment with young adolescents

This study investigated the ways in which the gender of group leader and client might affect treatment outcome with young adolescents. Seventh- and eighth-grade students were involved in programs for enhancing social competence. Mixed-sex groups of adolescents received treatment from either male or female group leaders. Results revealed gender differences between the male and female adolescents on the outcome measures, no difference on outcome due to leader gender, and one interaction effect on a measure of social skills between adolescent gender and group leader gender. Acquisition of social skills, which takes place through modeling and observation, may be influenced by matched gender between leaders and adolescents; however, other competencies and abilities do not appear sensitive to leader and adolescent gender.He received his Ph.D. at the University of Wisconsin-Madison. His major interests include developing and evaluating interventions for adolescents, social skills training, and practice evaluation for social workers.     

Book reviews

Computer Software — Legal Protection in the United Kingdom, 2nd edition Henry Carr and Richard Arnold Sweet and Maxwell 1992. ISBN 0 421 44380 4 £45

Legal Protection of Computer Programs in Europe — a Guide to the EC Directive Bridget Czarnota and Robert J Hart Butterworths 1991. ISBN 0 406 00542 7

Intellectual Property Rights in Sound Recordings, Film and Video J A L Sterling Sweet and Maxwell 1992. ISBN 0 421 4570 9

The European Market Place James Hogan Macmillan 1991. ISBN 0 333 51858 6

Intellectual Property D Bainbridge Pitman 1992. ISBN 0 273 034265 X     

Reviews

Scribe, Griot and Novelist: Narrative Interpreters of the Songhay Empire by Thomas A Hale. University of Florida Press, Gainesville (Florida, U.S.A.), 1990. xiv plus 313 pp. including notes, bibliography and index. £23.06. Hardback.

General History of Africa VII. Africa under Colonial Domination 1880–1935 (abridged edition) edited by A. Adu Boahenforthe UNESCO International Scientific Committee for the Drafting of a General History of Africa. UNESCO (Paris), University of California Press (Berkeley) and James Currey (London), 1990. xxi plus 387pp. including illustrations, bibliography and index. £4.95. Paperback.

South Africa: Constitutional Development ‐ A Multi‐disciplinary Approach by Donovan Marais. Southern Book Publishers, Johannesburg, 1989. 315pp. Notes and index. R37.50. Paperback.

Transport Planning for Third World Cities edited by Harry T. Dimitriou. Routledge, London, 1990. xxii plus 432pp. including figures, tables, notes, bibliography and index. £40.00. Hardback.

The Founder: Cecil Rhodes and the Pursuit of Power by Robert I. Rotberg with Miles F. Shore. Oxford University Press, New York, 1989. xxii plus 800pp. including maps, illustrations and bibliography. $35.00 and £25.00.

The Development of the Executive underthe Nigerian Constitutions, 1960–81 by J.D. Ojo. Ibadan University Press, Ibadan, 1985.189pp.

Cultural Forces in World Politics by Ali A. Mazrui. James Currey, London 1990.262pp. R46.60. Paperback.

Urban Markets ‐ Developing Informal Retailing by David Dewar and Vanessa Watson. Routledge, London, 1990. xii plus 154pp. £30.00. Hardback.

State‐Administered Rural Change: Agricultural Cooperatives in Kenya by Björn Gyllström. Routledge, London and New York, 1991. xvii plus 319pp. including figures, tables, appendices, notes, bibliography and index. Hardback.

The African Frontier: The Reproduction of Traditional African Societies. Edited and with an introduction by Igor Kopytoff. Indiana University Press, Bloomington and Indianapolis. 1987. vii plus 288pp. including maps, notes and index. R70.15. Hardback.

Studies in the Economic History of Southern Africa. Volume Two: South Africa, Lesotho and Swaziland edited by Z.A. Konczacki, Jane L Parpart and Timothy M. Shaw. Frank Cass & Co. Ltd., London, 1991. xvii plus 290pp. including maps, figures, tables, notes, bibliography and index. £35.00 Hardback. £19.50 Paperback.

Incentives and Agriculture in East Africa by Mats Lundahl. Routledge, London, 1990.223pp. Hardback.

African Agriculture: The Critical Choices edited by HA Amara and B. Founou‐Tchuigoua. UN University Press, Tokyo and Zed Books, London, 1990. 227 pp. Paperback.

A History of Agriculture in West Africa: A Guide to Information Sources by S.C. Saha. Studies in African Economic and Social Development, Volume 6, The Edwin Mellen Press, New York and Lampeter, Wales. 136pp. $49.95. Hardback.

Ethnographic Decision Tree Modelling by Christina H. Gladwin. Sage University Paper Series on Qualitative Research Methods Vol.9. Beverly Hills CALSage, 1989.96pp. $6.50. Paperback.

Samora Machel: A Biography by lain Christie. London: Panaf 1989. 181pp including photographs, bibliography and index. Paperback.

Mozambique: Norwegian Assistance in a Context of Crisis by Grete Brochmann & Arve Ofstad. Fantoft: Christian Michelsen Institute, 1990. vii plus 173pp. including tables, bibliography and index. Paperback.

Self‐Employment for Disabled People: Experiences from Africa and Asia by Malcolm Harper and Willi Momm. International Labour Office, Geneva, 1989. viii plus 85pp. Swiss Francs 15. Paperback.

Technology, Gender and Power in Africa by Patricia Stamp. Ottawa, Ontario, International Development Research Centre, 1989. x plus 185pp. Paperback.

The Devils are Among Us: The War for Namibia by Denis Herbstein and John Evenson. Zed Books Ltd., London, 1989. ix plus 202pp. including maps, photographs, bibliography, glossary and index. Paperback.

Zimbabwe: A Model for Namibia? A Comparison of Events in Zimbabwe‐Rhodesia 1979–1980 with the Situation in SWA in 1989by Ted Sutton‐Pryce. Academica, Pretoria, 1989. vii plus 77pp. including photographs and acknowledgements. R12.50 plus VAT. Hardback.

The Failure of the Centralised State: Institutions of Self‐Governance in Africa edited by James S. Wunsch and Dele Olowu. Westview Press, Boulder, San Francisco and Oxford, 1990. viii plus 334pp. including tables, notes, bibliography and index. Paperback.     

Results of the 2018 Rapid DNA Maturity Assessment

Three commercially available integrated rapid DNA instruments were tested as a part of a rapid DNA maturity assessment in July of 2018. The assessment was conducted with sets of blinded single-source reference samples provided to participants for testing on the individual rapid platforms within their laboratories. The data were returned to the National Institute of Standards and Technology (NIST) for review and analysis. Both FBI-defined automated review (Rapid DNA Analysis) and manual review (Modified Rapid DNA Analysis) of the datasets were conducted to assess the success of genotyping the 20 Combined DNA Index System (CODIS) core STR loci and full profiles generated by the instruments. Genotype results from the multiple platforms, participating laboratories, and STR typing chemistries were combined into a single analysis. The Rapid DNA Analysis resulted in a success rate of 80% for full profiles (85% for the 20 CODIS core loci) with automated analysis. Modified Rapid DNA Analysis resulted in a success rate of 90% for both the CODIS 20 core loci and full profiles (all attempted loci per chemistry). An analysis of the peak height ratios demonstrated that 95% of all heterozygous alleles were above 59% heterozygote balance. For base-pair sizing precision, the precision was below the standard 0.5 bp deviation for both the ANDE 6C System and the RapidHIT 200.