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Abstract: We report the first acute coronary fibrin thrombus arising upon atherosclerosis detected at autopsy in a man receiving chemotherapy for testicular carcinoma. The decedent was a smoker with no other known atherosclerotic risk factors. Histology revealed superficial atherosclerotic plaque erosion with endothelial necrosis and no intraplaque hemorrhage. A focus of intimal lymphoid infiltrates was noted away from the plaque. These findings raise the possibility of chemotherapy‐induced vascular damage as a factor in thrombogenesis. A review of Pubmed was performed which documented clinical reports of an association of chemotherapy with acute cardiac ischemia but no well described autopsy findings. Our case highlights the need for careful assessment of the coronary system in chemotherapy patients dying suddenly, particularly in the absence of significant atherosclerotic risk factors. Such postmortem examination will ensure thorough death investigation and may elucidate the pathogenesis of thrombosis with potential reduction in cardiac ischemic risks of chemotherapy patients.  相似文献   
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Despite a longstanding research tradition examining the intersection of policing and race, extant research focused almost exclusively on race and ethnicity in Black and White terms. As such, academic knowledge of the Hispanic experience remained opaque. In this study, data from a random sample of New York City residents were used to compare the perceptions of racial profiling among Hispanic and non-Hispanic citizens. In particular, factors relating to the perception that racial profiling was widespread, justified, and personally experienced were examined. Findings were grounded within the literature on police-citizen relations and racial profiling.  相似文献   
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There is a considerable amount of literature on embeddedness as part of sociological theory of economic action. Cultural and structural embeddedness often work together to shape the framework of economic relations, but, in an analysis of rural solicitors, we find unevenness between cultural and structural embeddedness. There are strong traits of the former, through a sense of place and belonging, but much less evidence of the latter with the structural relationships appearing relatively weak and underdeveloped. In a discussion supported by empirical data from a recent survey of rural legal practices in Wales, a number of causes are identified. The paper concludes that trends towards increasingly specialized rather than generalized legal service provision, set alongside the increasingly differentiated nature of rural space, suggest that the longer-term sustainability of rural legal practices may require both greater investment at the level of structural embeddedness alongside continuing reinvestment at the cultural level.  相似文献   
287.
The Lisbon Treaty, which entered into force in 2009, considerably reinforced the powers of the European Parliament. This article examines to what extent the European Parliament has become an important actor in EU counter-terrorism by focusing on the external dimension of this policy. It also analyses the impact that this potentially changing role has had on the external dimension of EU counter-terrorism. This article puts forward two inter-related claims. Firstly, the role of the European Parliament in the external dimension of EU counter-terrorism has significantly grown in recent years. Following the entry into force of the Lisbon Treaty in December 2009, the European Parliament has become a fully-fledged actor in the external dimension of EU counter-terrorism. Secondly, the reinforcement of the role of the European Parliament has also led to a strengthening of both accountability and oversight in the external dimension of EU counter-terrorism, although there are still some limitations in that respect.  相似文献   
288.
In 2003, the U.S. Department of Housing and Urban Development (HUD) prepared a study of the location patterns of the Housing Choice Voucher (HCV) program. This study became an important baseline for the evaluation of the HCV program and its ability to serve the goal of poverty deconcentration. The study examined the ability of HCV households in the 50 largest metropolitan areas to make entry to a broad array of neighborhoods and to locate in high-opportunity neighborhoods with low levels of poverty.

New data from HUD and the American Community Survey permit the study to be replicated. We find that vouchers continue to consume only a small portion of the housing stock, with relatively small amounts of spatial concentration. Unfortunately, only about one in five voucher households locate in low-poverty neighborhoods, and this share is rising only very slowly. If the nation wants to pursue poverty deconcentration through the HCV program, we cannot rely on the program, as it is now structured, to accomplish this goal. Additional incentives and constraints will be needed, similar to those that were part of the Gautreaux and Moving to Opportunity programs.  相似文献   

289.
The Iraqi Insurgency (2003–2011) has commonly been characterized as demonstrating the tendency for violence to cluster and diffuse at the local level. Recent research has demonstrated that insurgent attacks in Iraq cluster in time and space in a manner similar to that observed for the spread of a disease. The current study employs a variety of approaches common to the scientific study of criminal activities to advance our understanding of the correlates of observed patterns of the incidence and contagion of insurgent attacks. We hypothesize that the precise patterns will vary from one place to another, but that more attacks will occur in areas that are heavily populated, where coalition forces are active, and along road networks. To test these hypotheses, we use a fishnet to build a geographical model of Baghdad that disaggregates the city into more than 3000 grid cell locations. A number of logistic regression models with spatial and temporal lags are employed to explore patterns of local escalation and diffusion. These models demonstrate the validity of arguments under each of three models but suggest, overall, that risk heterogeneity arguments provide the most compelling and consistent account of the location of insurgency. In particular, the results demonstrate that violence is most likely at locations with greater population levels, higher density of roads, and military garrisons.  相似文献   
290.
Integrated care can introduce seamless coordinated pathways that are focused around the individual needs of patients, helping to prevent missed opportunities for intervention. Within offender healthcare, sequential funnelling through designated areas where screening can take place, along with co-location of services, lends itself to integrated working, at least in theory. However, within the offender healthcare pathway, service fragmentation and autonomous, disconnected (often referred to as siloed) working, has historically been the norm. If commissioned and designed to ensure and incentivise connections between services, whilst developing high quality service-focused research activities, pathways could enable clinical and social interventions, and outcomes, on a public health scale for these highly morbid populations. As such, offender healthcare offers a real opportunity to model integration for wider introduction across other health and social care areas. Discussed within is the call for integration, its concept, and its role within offender healthcare.  相似文献   
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