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Venture philanthropy presents a new model of research funding that is particularly helpful to those fighting orphan diseases, which actively manages the commercialization process to accelerate scientific progress and material outcomes. This paper begins by documenting the growing importance of foundations as a source of funding academic research as traditional funding from industry and government sources decline. Foundations are known for their innovative techniques and we consider the evolution of the ways that foundations fund academic research and form partnerships across academia and industry. We examine the example of the Cystic Fibrosis Foundation and the development of the drug Kalydeco® as a demonstration of the principals of strategic foundation funding. The Cystic Fibrosis Foundation adapted to a venture philanthropy model and took an active role in drug development, stewarding the commercialization process from funding basic scientific work in academic institutions, to making an equity investment in a start-up firm. We conclude by evaluating the advantages and disadvantages to venture philanthropy for the academic researchers, industry partners, foundations, and universities and consider an agenda for future research. 相似文献
23.
Alexandra E. Wink M.S. 《Journal of forensic sciences》2014,59(3):696-702
Skeletal age estimation using the pubic symphysis is a reliable and popular practice among forensic anthropologists. In instances in which accessing the skeleton is impossible, such as in the case of living individuals, three‐dimensional (3D) reconstructions of computed tomography (CT) scans can be created and analyzed for aspects of the biological profile. This study examined 3D reconstructions of pelvic CT scans of a sample of 44 live adults to estimate age using the Suchey–Brooks J Hum Evol 1990;5(3):227‐38 method. Images were created using OsiriX software (Pixmeo, Geneva, Switzerland). Estimated age ranges based on the 3D‐CT images captured the true age of the individual at the time of the CT scan 79.5% of the time with good intra‐observer reliability. The features best visualized on the 3D images included the ossific nodule and the pubic symphyseal rim. This study shows that clinical CT scanning parameters are adequate for creating 3D images to be analyzed for age using the pubic symphysis. 相似文献
24.
Robert Lawrence Kuhn 《北京周报(英文版)》2021,64(39):22-23
I have been coming to China for more than 30 years. I have traveled all across the country,visiting over 100 cities together with my long-term partner, Adam Zhu, for research and interviews, books and essays, television and documentaries. I have given much thought, over the years, as to what has brought about China's develop-mental miracle.
The underlying principles
One, a people who work hard to im-prove the lives of their families and the destiny of their country. 相似文献
25.
Trade and Industrial Policy as Levers for Sustainable Energy Technology Adoption? Experiences from Urban Latin America 下载免费PDF全文
Alexandra Mallett 《政策研究评论》2016,33(4):348-375
Debates abound regarding the link between trade and industrial policy and the adoption of sustainable energy technologies in developing countries. Some purport that open trade regimes support technology diffusion, while others indicate that more interventionist regimes are more conducive. This paper uses empirical evidence from Mexico City and São Paulo to argue that sustainable energy technology uptake can be more prevalent in settings with partially open trade policy regimes. These regimes have afforded countries more opportunities to develop local capabilities, which, in turn, has had knock‐on effects on sustainable energy technology uptake. Specifically, having more local technology sources (equipment, expertise) brought quicker access to these technologies, created more perceptions of technology “ownership,” fostered more effective mobilization, and helped create well‐established standards, which in turn contributed positively to sustainable energy technology uptake, while taxes and tariffs were less influential. 相似文献
26.
Among a German Sample of Forensic Patients,Previous Animal Abuse Mediates Between Psychopathy and Sadistic Actions 下载免费PDF全文
In an attempt to explain the relationship between psychopathy and severe violent behavior, this study associates previous animal abuse, psychopathy, and sadistic acting in forensic patients. Two topics are addressed: (i) whether previous animal abuse can be identified by a patient's Psychopathy Checklist profile and (ii) whether animal abuse statistically mediates between psychopathy and sadistic acting. In a German forensic hospital, 60 patients were investigated. Animal abuse was assessed using face‐to‐face interviews and the Psychopathy Checklist: Screening Version (PCL:SV), and sadistic acting was identified by file records.Discriminant analysis separated previous animal abuse (10/60) by high adolescent antisocial behavior, superficiality, lack of remorse, lack of empathy, and grandiosity. The mediation from psychopathy to sadistic acting (6/60) through animal abuse was found to be complete.The results, although sample size is limited and base rate of animal abuse and sadistic acting are low, fit with a model suggestive of animal abuse as a causal step toward sadistic crimes. Animal abuse correlates with callous, unemotional traits, and a development of sadistic crimes. 相似文献
27.
Alexandra R. Klales Ph.D. 《Journal of forensic sciences》2016,61(2):295-301
This research evaluates secular change in Phenice's (Am J Phys Anthropol, 30, 1969 and 297) three morphological traits of the pubis, as described by Klales et al. (Am J Phys Anthropol, 149, 2012 and 104): medial aspect of the ischio‐pubic ramus, subpubic contour, and ventral arc. Ordinal scores were collected for these traits and compared between a sample of innominates from the historical Hamann–Todd Collection (n = 170) and modern Bass Donated Collection (n = 129). Using the Freeman–Halton test, significant differences between temporal sample score frequencies were found for all traits in females and for the subpubic contour and ventral arc in males. Despite these findings, classification accuracy using logistic regression between the temporal periods remained low (68.7%). These results suggest that secular changes in trait expression are occurring; however, sex estimation methods using these traits and created with historical samples are still applicable to modern forensic cases. In fact, the secular changes occurring in these traits contribute to better classification accuracy between sexes in modern populations. 相似文献
28.
Alexandra Lysova 《Journal of family violence》2016,31(8):1005-1008
Despite growing evidence suggesting diverse manifestations of partner violence (PV) perpetrated by both men and women, a ‘violence against women’ perspective still appears to dominate theory, research, and policy responses. This article emphasizes the complexity of PV and argues that it can be embraced through the integration of contextual approaches. This can be done by (1) conceptualizing PV as a gender-inclusive, dynamic, and multidimensional phenomenon; (2) applying a violent events perspective to measuring the dynamics of violence in relationships; and (3) promoting a transformative change at the level of social policy that would embrace both women’s and men’s diverse experiences of PV, and thus achieve equality-based justice. 相似文献
29.
Natalie Flath Karin Tobin Kelly King Alexandra Lee Carl Latkin 《Journal of Ethnicity in Criminal Justice》2019,17(2):186-202
Encountering the criminal justice system at the first point of entry---an arrest---is associated with heightened HIV and Hepatitis risk behavior among people who inject drugs (PWIDS). Intervening structurally through the criminal justice system impacts public health; therefore, determining arrest patterns is an important tool for risk reduction. Among a sample of 740 PWIDs, and their social network members recruited from predominantly African-American neighborhoods in Baltimore City, a third were recently arrested in the previous six months, and of those, the arrests were disproportionately African-American persons and characterized as nonviolent, i.e., drug possession/attempt to purchase (38%) and loitering (29%). Poisson regression models were built adjusted for age, sex, race, education level, homelessness, and monthly income after exploring bivariable characteristics of arrests using chi-squared tests. Active drug use was associated with a recent arrest (adjusted prevalence ratio: aPR 2.38 95% CI 1.6, 3.6), in addition to participants who recently reported attending a syringe exchange program (aPR 1.45 95% CI 1.1, 2.0). Our findings are suggestive of recent media coverage and burgeoning research revealing the prioritization of policing resources toward both communities of color and neighborhoods of intensified drug trafficking. Further research is warranted to contextualize the operationalization of criminal justice resources and the impact on community health. 相似文献
30.
Alexandra B. Russell 《Family Court Review》2019,57(1):136-150
When it comes to child sex trafficking, health care clinics have become spaces of duality. While these facilities provide medical care to child victims, many argue that this facilitates traffickers in concealing evidence of child sex trafficking. This Note proposes an amendment to New York's Safe Harbor Act and various sections of the Social Services Law to cure legislative ambiguity with respect to health care clinics. The amendment will mandate that all state‐run health care clinics implement a uniform process, utilizing mental health professionals and a standardized interview process, to identify and report instances of potential child sex trafficking. 相似文献