Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case

For several years, the misuse of stimulant substances is increasingly observed both in the field of sport, to improve the functions of the body and therefore to be more performant, and also by non-athletes to make life more tolerable on a daily basis. Adrafinil, 2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide, is a drug designed for the treatment of narcolepsy by promoting an awakened state, and to treat alertness and neurological symptoms in the elderly. It is primarily metabolized in vivo to an active form, i.e. modafinil, 2-((diphenylmethyl)sulfinyl)acetamide. The World Anti-Doping Agency (WADA) banned these two drugs in sports in 2004. The authors report an authentic case involving adrafinil and modafinil. The laboratory was requested to test for adrafinil in a hair strand collected from a woman found in possession of vials of adrafinil and suspected of trafficking. A specific method was developed by liquid chromatography tandem mass spectrometry (LC-MS/MS). Unlike modafinil (varying from 6.8 to 13.9 ng/mg), adrafinil was not identified in the strand. The interpretation of the results was difficult because this is the first case describing human hair analysis. In order to be able to interpret the results, a self-administration study was conducted after an oral administration to a volunteer (200 mg) whose beard hair was collected 10 days after administration. The analysis of this specimen highlighted the presence of adrafinil at 0.8 ng/mg and modafinil at 0.5 ng/mg. These results demonstrate the dual identification of both compounds after a single consumption, even after administration of a low dose. According to these results, the analysis of the hair strand from the authentic case does not match with a consumption of adrafinil, in accordance with abuse of modafinil alone. Intelligence considered that this was a trafficking case of adrafinil, with no self-consumption.     

Social Motives Underlying Antisocial Behavior Across Middle School Grades

The goal of the study was to examine whether social motives (social mimicry, mutual attraction, and unreciprocated attraction) predict changes in antisocial behavior across middle school grades. The 2,003 initial participants (55% girls) were drawn from a larger longitudinal study of urban public school students: 44% Latino, 26% African-American, 10% Asian, 9% Caucasian, and 11% multiracial. Analyses of peer nominations and teacher-rated behavior included five waves of data between the fall of sixth grade and the spring of eighth grade (n = 1,260–1,347 for longitudinal analyses). Supporting the social mimicry hypothesis, students who associated peer-directed aggression with high social status in the beginning of middle school engaged in elevated levels of antisocial conduct during the second year in the new school. Additionally, unreciprocated attraction toward peers who bully others in the beginning of middle school was related to increased antisocial behavior in the last year of middle school. No support was obtained for the mutual attraction hypothesis. The findings provide insights about possible social motives underlying susceptibility to negative peer influence.

Mobilizing Interest: The Effects of Money on Citizen Participation in State Supreme Court Elections

In this article, we investigate one highly significant aspect of the role of money in judicial elections: whether campaign spending increases citizen participation in the recruitment and retention of judges. Specifically, by using a two-stage modeling strategy that allows us to separate the effects of challengers from the effects of money, we assess whether relatively expensive campaigns improve the chances that citizens will vote in the 260 supreme court elections held from 1990 through 2004 in 18 states using partisan or nonpartisan elections to staff the high court bench. We find that increased spending significantly improves citizen participation in these races. Whether measured as the overall spending in each election or in per capita terms, greater spending facilitates voting. We conclude, contrary to conventional wisdom about the deleterious effects of money in judicial elections, that by stimulating mass participation and giving voters greater ownership in the outcomes of these races, expensive campaigns strengthen the critical linkage between citizens and the bench and enhance the quality of democracy.     

Steering Agencies with Short-Term Authorizations

After World War II, the U.S. Congress began a process of engaging in what David Rosenbloom refers to as Congress-centered public administration. In this article, the author argues that the use of short-term authorizations by Congress facilitates congressional oversight and co-management of public programs. Using data from three case studies, the author shows that Congress is able to systematically, on a regularized basis, shape the overall goals, structures, and decision rules that govern agency activities. It can also promote research and analysis that will inform the reauthorization of a program by funding studies and requiring specific reports to be produced. The agencies are, in turn, able to implement the new legislative requirements over a given timeframe—typically four to six years—and do so in an environment that is relatively free from other congressional changes to the legislation underlying the program in question. During this time, the agency and Congress are able to determine what works and what does not work and to formulate changes that should be considered in the next reauthorization legislation.