Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case

For several years, the misuse of stimulant substances is increasingly observed both in the field of sport, to improve the functions of the body and therefore to be more performant, and also by non-athletes to make life more tolerable on a daily basis. Adrafinil, 2-((diphenylmethyl)sulfinyl)-N-hydroxyacetamide, is a drug designed for the treatment of narcolepsy by promoting an awakened state, and to treat alertness and neurological symptoms in the elderly. It is primarily metabolized in vivo to an active form, i.e. modafinil, 2-((diphenylmethyl)sulfinyl)acetamide. The World Anti-Doping Agency (WADA) banned these two drugs in sports in 2004. The authors report an authentic case involving adrafinil and modafinil. The laboratory was requested to test for adrafinil in a hair strand collected from a woman found in possession of vials of adrafinil and suspected of trafficking. A specific method was developed by liquid chromatography tandem mass spectrometry (LC-MS/MS). Unlike modafinil (varying from 6.8 to 13.9 ng/mg), adrafinil was not identified in the strand. The interpretation of the results was difficult because this is the first case describing human hair analysis. In order to be able to interpret the results, a self-administration study was conducted after an oral administration to a volunteer (200 mg) whose beard hair was collected 10 days after administration. The analysis of this specimen highlighted the presence of adrafinil at 0.8 ng/mg and modafinil at 0.5 ng/mg. These results demonstrate the dual identification of both compounds after a single consumption, even after administration of a low dose. According to these results, the analysis of the hair strand from the authentic case does not match with a consumption of adrafinil, in accordance with abuse of modafinil alone. Intelligence considered that this was a trafficking case of adrafinil, with no self-consumption.     

Making sense of communitarianism: the Bolivian experience

In Bolivia, the state and society is undergoing radical transformations. The indigenous movements have revitalised traditions such as communitarianism, and ‘communitarian development’ has come to the forefront of Bolivian politics. The aim of this article is to identify what communitarian development means in the Bolivian context; how it is conceived and how it is practiced. I examine how communitarian development is conceptualised in the Aymara indigenous movement and in policy documents, and analyse what communitarianism might mean to people who uphold such values. I identify and discuss five different but intertwined significations; communitarian economy, communitarian work, communitarian management, communitarian law and communitarian values. I show that Bolivian communitarianism contains conceptualisations of cultural phenomena, which emerge at the nexus of experiences and expectations for the future, and argue that, despite tensions and pitfalls, communitarian development has the potential to increase indigenous wellbeing and agency and to contribute to a more nuanced understanding of what communitarianism is, or could be.     

<Emphasis Type="Italic">BodiMojo</Emphasis>: Efficacy of a Mobile-Based Intervention in Improving Body Image and Self-Compassion among Adolescents

Mobile interventions promoting positive body image are lacking. This study presents a randomized controlled evaluation of BodiMojo, a mobile application (app) intervention grounded in self-compassion to promote positive body image. A sample of 274 adolescents, mean (SD) age?=?18.36 (1.34) years, 74% female, were allocated to a control group or used BodiMojo for 6 weeks. Appearance esteem, body image flexibility, appearance comparison, mood, and self-compassion were assessed at baseline, 6, and 12 weeks. Significant time by group interactions emerged for appearance esteem and self-compassion, with appearance esteem and self-compassion increasing in the intervention relative to the control group. These findings provide preliminary support for BodiMojo, a cost-effective mobile app for positive body image.     

Social Motives Underlying Antisocial Behavior Across Middle School Grades

The goal of the study was to examine whether social motives (social mimicry, mutual attraction, and unreciprocated attraction) predict changes in antisocial behavior across middle school grades. The 2,003 initial participants (55% girls) were drawn from a larger longitudinal study of urban public school students: 44% Latino, 26% African-American, 10% Asian, 9% Caucasian, and 11% multiracial. Analyses of peer nominations and teacher-rated behavior included five waves of data between the fall of sixth grade and the spring of eighth grade (n = 1,260–1,347 for longitudinal analyses). Supporting the social mimicry hypothesis, students who associated peer-directed aggression with high social status in the beginning of middle school engaged in elevated levels of antisocial conduct during the second year in the new school. Additionally, unreciprocated attraction toward peers who bully others in the beginning of middle school was related to increased antisocial behavior in the last year of middle school. No support was obtained for the mutual attraction hypothesis. The findings provide insights about possible social motives underlying susceptibility to negative peer influence.