Identification of two fire victims by comparative nuclear DNA typing of skeletal remains and stored umbilical tissues

We describe here our collaborative efforts in identifying 2 fatalities of a fire disaster by using a variety of identification techniques. Postmortem findings in both cases were reinforced using Short Tandem Repeat (STR) DNA technology to establish with a high degree of certainty the identities of 2 child victims. STR markers used in the present study include HUMAMEL, HUMCSFIPO, HUMTHO1, HUMvWA, HUMFES/FPS, HUMF13A01, HUMFOLP23, D8S3O6, HUMFGA, and HUMTPOX. Unambiguous identification was made possible through matching DNA profiles generated from skeletal remains with those from umbilical tissues. These tissues were kept by their mothers in accordance with a Philippine tradition and were submitted for DNA analysis. Of the DNA profiles generated from exhumed bone samples of 21 child victims, comparison with the genetic profiles of children A and B obtained from umbilical tissues showed consistent DNA matches with remains 1756 and 1758, respectively.     

Allele sharing in first-degree and unrelated pairs of individuals in the Ge F I AmpFlSTR Profiler Plus database

Eleven Italian forensic laboratories participated in a population study based on the AB Profiler Plus loci with proficiency testing. The validated database, including 1340 individuals, is available on-line. Tests for Hardy-Weinberg equilibrium, gametic unbalance, and heterogeneity of gene frequency were generally not significant. Gene frequencies at each locus were consistent with those of two previously published Italian studies, but different from a third. Individuals of each subsample were paired, and the total number of alleles shared across the nine loci was determined in each pair. The analysis was replicated over the total sample. In addition, two samples of mother-child pairs (N=315) and full-sib pairs (N=91) were subjected to allele sharing analysis. The resulting distributions were sufficiently distinct from the sample of unrelated pairs as to be of practical usefulness.     

The university and the human sciences

The current malaise affecting the university in general and the human sciences in particular has a deeper origin than is usually recognized. It has to do with the gap between science and culture, between the scientific way of dealing with things and the ordinary-lifeway of dealing with them. The more the university is seen as the bastion of science, the less those sciences, which traditionally deal with human affairs as seen from the ordinary, common sense point of view, are taken seriously. It is particularly the Geisteswissenschaften which are de facto depreciated. The usual reaction is an attempt to ever more professionalism and methodological rigidity also in these sciences. This leads to disastrous consequences both for the Geisteswissenschaften and for the university as a whole. This revised version was published online in July 2006 with corrections to the Cover Date.     

About pigs?: Decisions,outcomes and project planning

At the heart of a misleading conceptualisation of policy practice is what we refer to as the ‘common-sense’, ‘mainstream’ or ‘linear’ model of public policy. This model represents public policy as a dichotomous linear process, of two distinct but sequential phases. The process begins with a decision or a sequence of activities which culminate in a decision. The decision also constitutes a ‘policy’. Then there is a break. On the other side of the divide is ‘policy implementation’ … the unthinking acceptance of the mainstream model in policy analysis has … important and dangeous consequences (Clay and Schaffer, 1985, p.3).     

Trends in policy sciences research: determinants and developments

Abstract. The policy sciences have been evolving as a discipline over the past thirty years, but the development has been less than clear, its directions somewhat uncertain. Still, the founding characteristics, as set forth by its early proponents, have remained relevant and relatively constant. The policy sciences have been defined by their multidisciplinary perspective, their problem-oriented, contextual approach, and their treatment of normative standards. This paper reviews the development of the policy sciences in light of these three hallmarks and observes how each has experienced great variations. Finally, the paper suggests six emerging conditions which could have a significant effect on the future development and practice of the policy sciences.     

Sizing the government

Is there such a thing as an optimal government size? We investigate the so-called Armey curve, which claims an inverted U-shaped relationship between government size and economic performance, using non-parametric Data Envelopment Analysis (DEA). The DEA scores are linked to control variables, such as initial per capita income, openness, population density, urbanization, country size and family size. For 23 OECD-countries we estimate the country specific efficiency scores, which reveal the extent to which a country uses excess public resources to achieve the observed growth rate of GDP.